American Heart Association
Heart Failure and Cardiomyopathy: From Bench to Bedside
Moderated Digital Poster Session
Clinical Science Zone 2, Moderated Digital Poster 22
Nov 8th , 03:15 PM - 04:25 PM
03 : 15 PM
Inhibition of PARP-1 selectively improves diastolic function in diabetic rat: potential role of glycocalyx protection.
Negera Getandale, Stafford Irene, Surikow Sven, Chapman Matthew, Dudhwala Zenab, Horowitz John, Chong Cher-rin
Final Pr. ID: MP968
Authors: Negera Getandale, Stafford Irene, Surikow Sven, Chapman Matthew, Dudhwala Zenab, Horowitz John, Chong Cher-rin
Keywords: Heart failure , Diabetes Mellitus
03 : 22 PM
RSPO1-Mediated Macrophage Polarization Drives Ventricular Remodeling and Heart Failure after Myocardial Infarctio
Zhuang Lingfang, Dai Rui, Cao Qing, Chen Kang
Final Pr. ID: MP969
Authors: Zhuang Lingfang, Dai Rui, Cao Qing, Chen Kang
Keywords: Acute coronary syndromes , Advancing heart failure , Cell physiology , Heart failure , Ventricular remodeling
03 : 29 PM
Monoamine Oxidase-A Promotes Cardiomyocyte Senescence and Aggravates Diastolic Dysfunction in HFpEF via cGAS-STING Signaling
Li Zhuqing, Lu Chengzhi, Ai Chunbo
Final Pr. ID: MP970
Authors: Li Zhuqing, Lu Chengzhi, Ai Chunbo
Keywords: Heart failure , Cell signaling , Oxidative Stress
03 : 36 PM
β1-adrenergic autoantibodies (β1-AA) augment macropinocytosis in CD4+ T cells, leading to the expansion of CD4+CD28− T cell subsets in heart failure.
Sun Fei, Yao Junyan, Li Bingjie, Zhang Suli, Liu Huirong
Final Pr. ID: MP971
Authors: Sun Fei, Yao Junyan, Li Bingjie, Zhang Suli, Liu Huirong
Keywords: Heart failure , Autoimmune , Immune system , Pathology , Adrenergic
03 : 43 PM
Localized hydrogel delivery of a small molecule inhibitor of fibroblast activation protein alters the trajectory of post-myocardial infarction remodeling
Barlow Shayne, Freeburg Lisa, Maduka Chima, Ruiz Ricky, Jones Traci, Hofacre Courtney, Al-soudi Jumanah, Burdick Jason, Spinale Francis
Final Pr. ID: MP972
Authors: Barlow Shayne, Freeburg Lisa, Maduka Chima, Ruiz Ricky, Jones Traci, Hofacre Courtney, Al-soudi Jumanah, Burdick Jason, Spinale Francis
Keywords: HFrEF , Heart failure , Ischemia reperfusion , Cardiac injection
03 : 50 PM
A Phase I, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of N-acetylgalactosamine Small Interfering RNA Conjugate, BPR-30221616, in Healthy Participants, for Potential Treatment of Transthyretin Amyloidosis
Han Xiaohong, Chen Rui, Cheng Xiwen, Zhang Langxi, Huang Haoxi, Fan Shengjun
Final Pr. ID: MP973
Authors: Han Xiaohong, Chen Rui, Cheng Xiwen, Zhang Langxi, Huang Haoxi, Fan Shengjun
Keywords: Amyloidosis , Cardiomyopathy , Clinical trials , Heart failure , Heart disease
03 : 57 PM
Vutrisiran Improved Outcomes Versus Placebo in Patients with Transthyretin Amyloidosis with Cardiomyopathy and Severe Chronic Kidney Disease: Post Hoc Analysis of HELIOS-B
Sheikh Farooq, Eraly Satish, Moffitt Colleen, Yilmaz Ali, Dang Julien, Fontana Marianna, Audard Vincent, Garcia-pavia Pablo, Khouri Michel, Jobbe-duval Antoine, Brailovsky Yevgeniy, Zheng Hua
Final Pr. ID: MP975
Authors: Sheikh Farooq, Eraly Satish, Moffitt Colleen, Yilmaz Ali, Dang Julien, Fontana Marianna, Audard Vincent, Garcia-pavia Pablo, Khouri Michel, Jobbe-duval Antoine, Brailovsky Yevgeniy, Zheng Hua
Keywords: Amyloidosis , Chronic Kidney Disease , Renal function
04 : 04 PM
Effect of Aficamten in Women Compared with Men with Obstructive Hypertrophic Cardiomyopathy
Wang Xiaowen, Nassif Michael, Olivotto Iacopo, Jacoby Daniel, Heitner Stephen, Wohltman Amy, Solomon Scott, Hegde Sheila, Pabon Maria, Abraham Theodore, Barriales-villa Roberto, Claggett Brian, Coats Caroline, Maron Martin, Masri Ahmad, Meder Benjamin
Final Pr. ID: MP976
Authors: Wang Xiaowen, Nassif Michael, Olivotto Iacopo, Jacoby Daniel, Heitner Stephen, Wohltman Amy, Solomon Scott, Hegde Sheila, Pabon Maria, Abraham Theodore, Barriales-villa Roberto, Claggett Brian, Coats Caroline, Maron Martin, Masri Ahmad, Meder Benjamin
Keywords: Hypertrophic cardiomyopathy , Echocardiography , Sex differences , Cardiomyopathy
04 : 11 PM
Acoramidis Reduces All-Cause Mortality and Cardiovascular-Related Hospitalizations Through Month 42 in Transthyretin Amyloid Cardiomyopathy Across All Pre-specified Patient Subgroups
Stern Lily, Fine Nowell, Maurer Mathew, Grogan Martha, Ambardekar Amrut, Grodin Justin, Soman Prem, Garcia-pavia Pablo, Chen Chris, Siddhanti Suresh, Tamby Jean-francois, Fox Jonathan
Final Pr. ID: MP977
Authors: Stern Lily, Fine Nowell, Maurer Mathew, Grogan Martha, Ambardekar Amrut, Grodin Justin, Soman Prem, Garcia-pavia Pablo, Chen Chris, Siddhanti Suresh, Tamby Jean-francois, Fox Jonathan
Keywords: Amyloidosis , Cardiomyopathy , Clinical trials , Efficacy , Outcomes
03 : 36 PM
β1-adrenergic autoantibodies (β1-AA) augment macropinocytosis in CD4+ T cells, leading to the expansion of CD4+CD28− T cell subsets in heart failure.
Sun Fei, Yao Junyan, Li Bingjie, Zhang Suli, Liu Huirong
Final Pr. ID: MP971
Authors: Sun Fei, Yao Junyan, Li Bingjie, Zhang Suli, Liu Huirong
Keywords: Heart failure , Autoimmune , Immune system , Pathology , Adrenergic
03 : 50 PM
A Phase I, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of N-acetylgalactosamine Small Interfering RNA Conjugate, BPR-30221616, in Healthy Participants, for Potential Treatment of Transthyretin Amyloidosis
Han Xiaohong, Chen Rui, Cheng Xiwen, Zhang Langxi, Huang Haoxi, Fan Shengjun
Final Pr. ID: MP973
Authors: Han Xiaohong, Chen Rui, Cheng Xiwen, Zhang Langxi, Huang Haoxi, Fan Shengjun
Keywords: Amyloidosis , Cardiomyopathy , Clinical trials , Heart failure , Heart disease
04 : 11 PM
Acoramidis Reduces All-Cause Mortality and Cardiovascular-Related Hospitalizations Through Month 42 in Transthyretin Amyloid Cardiomyopathy Across All Pre-specified Patient Subgroups
Stern Lily, Fine Nowell, Maurer Mathew, Grogan Martha, Ambardekar Amrut, Grodin Justin, Soman Prem, Garcia-pavia Pablo, Chen Chris, Siddhanti Suresh, Tamby Jean-francois, Fox Jonathan
Final Pr. ID: MP977
Authors: Stern Lily, Fine Nowell, Maurer Mathew, Grogan Martha, Ambardekar Amrut, Grodin Justin, Soman Prem, Garcia-pavia Pablo, Chen Chris, Siddhanti Suresh, Tamby Jean-francois, Fox Jonathan
Keywords: Amyloidosis , Cardiomyopathy , Clinical trials , Efficacy , Outcomes
04 : 04 PM
Effect of Aficamten in Women Compared with Men with Obstructive Hypertrophic Cardiomyopathy
Wang Xiaowen, Nassif Michael, Olivotto Iacopo, Jacoby Daniel, Heitner Stephen, Wohltman Amy, Solomon Scott, Hegde Sheila, Pabon Maria, Abraham Theodore, Barriales-villa Roberto, Claggett Brian, Coats Caroline, Maron Martin, Masri Ahmad, Meder Benjamin
Final Pr. ID: MP976
Authors: Wang Xiaowen, Nassif Michael, Olivotto Iacopo, Jacoby Daniel, Heitner Stephen, Wohltman Amy, Solomon Scott, Hegde Sheila, Pabon Maria, Abraham Theodore, Barriales-villa Roberto, Claggett Brian, Coats Caroline, Maron Martin, Masri Ahmad, Meder Benjamin
Keywords: Hypertrophic cardiomyopathy , Echocardiography , Sex differences , Cardiomyopathy
03 : 15 PM
Inhibition of PARP-1 selectively improves diastolic function in diabetic rat: potential role of glycocalyx protection.
Negera Getandale, Stafford Irene, Surikow Sven, Chapman Matthew, Dudhwala Zenab, Horowitz John, Chong Cher-rin
Final Pr. ID: MP968
Authors: Negera Getandale, Stafford Irene, Surikow Sven, Chapman Matthew, Dudhwala Zenab, Horowitz John, Chong Cher-rin
Keywords: Heart failure , Diabetes Mellitus
03 : 43 PM
Localized hydrogel delivery of a small molecule inhibitor of fibroblast activation protein alters the trajectory of post-myocardial infarction remodeling
Barlow Shayne, Freeburg Lisa, Maduka Chima, Ruiz Ricky, Jones Traci, Hofacre Courtney, Al-soudi Jumanah, Burdick Jason, Spinale Francis
Final Pr. ID: MP972
Authors: Barlow Shayne, Freeburg Lisa, Maduka Chima, Ruiz Ricky, Jones Traci, Hofacre Courtney, Al-soudi Jumanah, Burdick Jason, Spinale Francis
Keywords: HFrEF , Heart failure , Ischemia reperfusion , Cardiac injection
03 : 29 PM
Monoamine Oxidase-A Promotes Cardiomyocyte Senescence and Aggravates Diastolic Dysfunction in HFpEF via cGAS-STING Signaling
Li Zhuqing, Lu Chengzhi, Ai Chunbo
Final Pr. ID: MP970
Authors: Li Zhuqing, Lu Chengzhi, Ai Chunbo
Keywords: Heart failure , Cell signaling , Oxidative Stress
03 : 22 PM
RSPO1-Mediated Macrophage Polarization Drives Ventricular Remodeling and Heart Failure after Myocardial Infarctio
Zhuang Lingfang, Dai Rui, Cao Qing, Chen Kang
Final Pr. ID: MP969
Authors: Zhuang Lingfang, Dai Rui, Cao Qing, Chen Kang
Keywords: Acute coronary syndromes , Advancing heart failure , Cell physiology , Heart failure , Ventricular remodeling
03 : 57 PM
Vutrisiran Improved Outcomes Versus Placebo in Patients with Transthyretin Amyloidosis with Cardiomyopathy and Severe Chronic Kidney Disease: Post Hoc Analysis of HELIOS-B
Sheikh Farooq, Eraly Satish, Moffitt Colleen, Yilmaz Ali, Dang Julien, Fontana Marianna, Audard Vincent, Garcia-pavia Pablo, Khouri Michel, Jobbe-duval Antoine, Brailovsky Yevgeniy, Zheng Hua
Final Pr. ID: MP975
Authors: Sheikh Farooq, Eraly Satish, Moffitt Colleen, Yilmaz Ali, Dang Julien, Fontana Marianna, Audard Vincent, Garcia-pavia Pablo, Khouri Michel, Jobbe-duval Antoine, Brailovsky Yevgeniy, Zheng Hua
Keywords: Amyloidosis , Chronic Kidney Disease , Renal function