American Heart Association
Targeting the Thickened Heart: Advances in Hypertrophic Cardiomyopathy Therapy
Moderated Digital Poster Session
Clinical Science Zone 2, Moderated Digital Poster 24
Nov 8th , 10:45 AM - 12:00 PM
10 : 45 AM
Prevalence and Predictors of Left Ventricular Systolic Dysfunction during Treatment with Mavacamten for Obstructive Hypertrophic Cardiomyopathy
Massera Daniele, Adlestein Elizabeth, Li Yi, Frejat Sumar, Castro Alvarez Isabel, Alsaloum Marissa, Wu Woon, Reuter Maria, Sherrid Mark
Final Pr. ID: MP1037
Authors: Massera Daniele, Adlestein Elizabeth, Li Yi, Frejat Sumar, Castro Alvarez Isabel, Alsaloum Marissa, Wu Woon, Reuter Maria, Sherrid Mark
Keywords: Hypertrophic cardiomyopathy , Outcomes
10 : 52 AM
Long-Term Outcomes of Obstructive Hypertrophic Cardiomyopathy Undergoing Surgical Myectomy: Is an Earlier Intervention Better?
Jadam Shada, Sultana Sana, Abusafia Mohammed, Gaballa Andrew, Ospina Susan, Rutkowski Kathryn, Xu Bo, Popovic Zoran, Wierup Per, Smedira Nicholas, Desai Milind
Final Pr. ID: MP1038
Authors: Jadam Shada, Sultana Sana, Abusafia Mohammed, Gaballa Andrew, Ospina Susan, Rutkowski Kathryn, Xu Bo, Popovic Zoran, Wierup Per, Smedira Nicholas, Desai Milind
Keywords: Hypertrophic cardiomyopathy , Surgery , Mortality , Symptom management
10 : 59 AM
Mavacamten: Real-World Experience from 34 Months of the Risk Evaluation and Mitigation Strategy (REMS) Program
Desai Milind, Massera Daniele, Seto Dewey, Cheung Michael, Afsari Sonia, Schuler Patricia, Rodriguez Liza, Lama Sonie, Bastien Arnaud, Pipes Gordon, Bhatt Jaideep, Martinez Matthew
Final Pr. ID: MP1039
Authors: Desai Milind, Massera Daniele, Seto Dewey, Cheung Michael, Afsari Sonia, Schuler Patricia, Rodriguez Liza, Lama Sonie, Bastien Arnaud, Pipes Gordon, Bhatt Jaideep, Martinez Matthew
Keywords: Cardiac hypertrophy , Heart failure , Ventricular function , Left Ventricular
11 : 06 AM
Long-Term Clinical Outcomes of SGLT2 Inhibitor Use in Hypertrophic Cardiomyopathy: A Multicenter Retrospective Cohort Study
Badr Amro, Awad Kamal, Abbas Mohammed Tiseer, Abo Abdullah Humam, Sheashaa Hesham, Mousa Hana, Abdulrahman Senjab, Suppah Mustafa, Arsanjani Reza, Ayoub Chadi, Alsidawi Said
Final Pr. ID: MP1040
Authors: Badr Amro, Awad Kamal, Abbas Mohammed Tiseer, Abo Abdullah Humam, Sheashaa Hesham, Mousa Hana, Abdulrahman Senjab, Suppah Mustafa, Arsanjani Reza, Ayoub Chadi, Alsidawi Said
Keywords: Acute heart failure
11 : 13 AM
Patient-Reported Outcomes in Patients with Symptomatic, Obstructive Hypertrophic Cardiomyopathy Treated with Mavacamten: Real-world Observations through Week 30 from the COMPASS-HCM Study
Wang Andrew, Han Eileen, Zhong Yue, Schuler Patricia, Wang Yan, Yang Min, Martins Bruno, Spertus John
Final Pr. ID: MP1041
Authors: Wang Andrew, Han Eileen, Zhong Yue, Schuler Patricia, Wang Yan, Yang Min, Martins Bruno, Spertus John
Keywords: Hypertrophic cardiomyopathy , Cardiomyopathy
11 : 20 AM
Aficamten is safe and effective in oHCM with comorbidities obesity, hypertension, and diabetes: a SEQUOIA-HCM sub-study
Lee Matthew, Abraham Theodore, Claggett Brian, Maron Martin, Miao Zi, Meder Benjamin, Olivotto Iacopo, Heitner Stephen, Jacoby Daniel, Malik Fady, Kupfer Stuart, Wohltman Amy, Coats Caroline
Final Pr. ID: MP1042
Authors: Lee Matthew, Abraham Theodore, Claggett Brian, Maron Martin, Miao Zi, Meder Benjamin, Olivotto Iacopo, Heitner Stephen, Jacoby Daniel, Malik Fady, Kupfer Stuart, Wohltman Amy, Coats Caroline
Keywords: Clinical trials , Diabetes Mellitus , Hypertension , Hypertrophic cardiomyopathy , Obesity
Berman Brandon, Bonilla Harrison, Guardia Joshua, Tsyngauz Esther
Final Pr. ID: MP1043
Authors: Berman Brandon, Bonilla Harrison, Guardia Joshua, Tsyngauz Esther
Keywords: Drugs , Cardiomyopathy , Cardioprotective drugs , Mortality , Myocardial infarction
11 : 34 AM
High-throughput functional interrogation of myosin heavy chain 7 variants in genome-edited cardiomyocytes to determine variant effect
Friedman Clayton, Fayer Shawn, Murry Chuck, Starita Lea, Fowler Douglas, Yang Daniel
Final Pr. ID: MP1044
Authors: Friedman Clayton, Fayer Shawn, Murry Chuck, Starita Lea, Fowler Douglas, Yang Daniel
Keywords: Hypertrophic cardiomyopathy , Genetics , Myosin , Stem cells
11 : 41 AM
Hypertrophic Cardiomyopathy in a Patient With BAG3-Associated Charcot-Marie-Tooth Disease: A Rare Cardiac Manifestation
Simmons Jack, Hyder Syed, Lertwilaiwittaya Pongtawat, Smith Catherine, Patel Nirav, Arora Garima, Oldacre Jordan, Arora Pankaj
Final Pr. ID: MP1045
Authors: Simmons Jack, Hyder Syed, Lertwilaiwittaya Pongtawat, Smith Catherine, Patel Nirav, Arora Garima, Oldacre Jordan, Arora Pankaj
Keywords: Genetics , Genetic testing , Hypertrophic cardiomyopathy , Cardiac MRI , Echocardiography
11 : 48 AM
In Vitro Investigation of the Pathophysiological Mechanisms Underlying Severe Cardiomyopathic Phenotypes Associated with Noonan Syndrome with Multiple Lentigines
Nakagama Sachie, Nakagama Shun, Yamasaki Masataka, Ito Masamichi, Kido Yasutoshi, Nakagama Yu
Final Pr. ID: MP1046
Authors: Nakagama Sachie, Nakagama Shun, Yamasaki Masataka, Ito Masamichi, Kido Yasutoshi, Nakagama Yu
Keywords: Hypertrophic cardiomyopathy , Cell signaling , Stem/progenitor cells
11 : 20 AM
Aficamten is safe and effective in oHCM with comorbidities obesity, hypertension, and diabetes: a SEQUOIA-HCM sub-study
Lee Matthew, Abraham Theodore, Claggett Brian, Maron Martin, Miao Zi, Meder Benjamin, Olivotto Iacopo, Heitner Stephen, Jacoby Daniel, Malik Fady, Kupfer Stuart, Wohltman Amy, Coats Caroline
Final Pr. ID: MP1042
Authors: Lee Matthew, Abraham Theodore, Claggett Brian, Maron Martin, Miao Zi, Meder Benjamin, Olivotto Iacopo, Heitner Stephen, Jacoby Daniel, Malik Fady, Kupfer Stuart, Wohltman Amy, Coats Caroline
Keywords: Clinical trials , Diabetes Mellitus , Hypertension , Hypertrophic cardiomyopathy , Obesity
11 : 34 AM
High-throughput functional interrogation of myosin heavy chain 7 variants in genome-edited cardiomyocytes to determine variant effect
Friedman Clayton, Fayer Shawn, Murry Chuck, Starita Lea, Fowler Douglas, Yang Daniel
Final Pr. ID: MP1044
Authors: Friedman Clayton, Fayer Shawn, Murry Chuck, Starita Lea, Fowler Douglas, Yang Daniel
Keywords: Hypertrophic cardiomyopathy , Genetics , Myosin , Stem cells
11 : 41 AM
Hypertrophic Cardiomyopathy in a Patient With BAG3-Associated Charcot-Marie-Tooth Disease: A Rare Cardiac Manifestation
Simmons Jack, Hyder Syed, Lertwilaiwittaya Pongtawat, Smith Catherine, Patel Nirav, Arora Garima, Oldacre Jordan, Arora Pankaj
Final Pr. ID: MP1045
Authors: Simmons Jack, Hyder Syed, Lertwilaiwittaya Pongtawat, Smith Catherine, Patel Nirav, Arora Garima, Oldacre Jordan, Arora Pankaj
Keywords: Genetics , Genetic testing , Hypertrophic cardiomyopathy , Cardiac MRI , Echocardiography
11 : 48 AM
In Vitro Investigation of the Pathophysiological Mechanisms Underlying Severe Cardiomyopathic Phenotypes Associated with Noonan Syndrome with Multiple Lentigines
Nakagama Sachie, Nakagama Shun, Yamasaki Masataka, Ito Masamichi, Kido Yasutoshi, Nakagama Yu
Final Pr. ID: MP1046
Authors: Nakagama Sachie, Nakagama Shun, Yamasaki Masataka, Ito Masamichi, Kido Yasutoshi, Nakagama Yu
Keywords: Hypertrophic cardiomyopathy , Cell signaling , Stem/progenitor cells
11 : 06 AM
Long-Term Clinical Outcomes of SGLT2 Inhibitor Use in Hypertrophic Cardiomyopathy: A Multicenter Retrospective Cohort Study
Badr Amro, Awad Kamal, Abbas Mohammed Tiseer, Abo Abdullah Humam, Sheashaa Hesham, Mousa Hana, Abdulrahman Senjab, Suppah Mustafa, Arsanjani Reza, Ayoub Chadi, Alsidawi Said
Final Pr. ID: MP1040
Authors: Badr Amro, Awad Kamal, Abbas Mohammed Tiseer, Abo Abdullah Humam, Sheashaa Hesham, Mousa Hana, Abdulrahman Senjab, Suppah Mustafa, Arsanjani Reza, Ayoub Chadi, Alsidawi Said
Keywords: Acute heart failure
10 : 52 AM
Long-Term Outcomes of Obstructive Hypertrophic Cardiomyopathy Undergoing Surgical Myectomy: Is an Earlier Intervention Better?
Jadam Shada, Sultana Sana, Abusafia Mohammed, Gaballa Andrew, Ospina Susan, Rutkowski Kathryn, Xu Bo, Popovic Zoran, Wierup Per, Smedira Nicholas, Desai Milind
Final Pr. ID: MP1038
Authors: Jadam Shada, Sultana Sana, Abusafia Mohammed, Gaballa Andrew, Ospina Susan, Rutkowski Kathryn, Xu Bo, Popovic Zoran, Wierup Per, Smedira Nicholas, Desai Milind
Keywords: Hypertrophic cardiomyopathy , Surgery , Mortality , Symptom management
10 : 59 AM
Mavacamten: Real-World Experience from 34 Months of the Risk Evaluation and Mitigation Strategy (REMS) Program
Desai Milind, Massera Daniele, Seto Dewey, Cheung Michael, Afsari Sonia, Schuler Patricia, Rodriguez Liza, Lama Sonie, Bastien Arnaud, Pipes Gordon, Bhatt Jaideep, Martinez Matthew
Final Pr. ID: MP1039
Authors: Desai Milind, Massera Daniele, Seto Dewey, Cheung Michael, Afsari Sonia, Schuler Patricia, Rodriguez Liza, Lama Sonie, Bastien Arnaud, Pipes Gordon, Bhatt Jaideep, Martinez Matthew
Keywords: Cardiac hypertrophy , Heart failure , Ventricular function , Left Ventricular
Berman Brandon, Bonilla Harrison, Guardia Joshua, Tsyngauz Esther
Final Pr. ID: MP1043
Authors: Berman Brandon, Bonilla Harrison, Guardia Joshua, Tsyngauz Esther
Keywords: Drugs , Cardiomyopathy , Cardioprotective drugs , Mortality , Myocardial infarction
11 : 13 AM
Patient-Reported Outcomes in Patients with Symptomatic, Obstructive Hypertrophic Cardiomyopathy Treated with Mavacamten: Real-world Observations through Week 30 from the COMPASS-HCM Study
Wang Andrew, Han Eileen, Zhong Yue, Schuler Patricia, Wang Yan, Yang Min, Martins Bruno, Spertus John
Final Pr. ID: MP1041
Authors: Wang Andrew, Han Eileen, Zhong Yue, Schuler Patricia, Wang Yan, Yang Min, Martins Bruno, Spertus John
Keywords: Hypertrophic cardiomyopathy , Cardiomyopathy
10 : 45 AM
Prevalence and Predictors of Left Ventricular Systolic Dysfunction during Treatment with Mavacamten for Obstructive Hypertrophic Cardiomyopathy
Massera Daniele, Adlestein Elizabeth, Li Yi, Frejat Sumar, Castro Alvarez Isabel, Alsaloum Marissa, Wu Woon, Reuter Maria, Sherrid Mark
Final Pr. ID: MP1037
Authors: Massera Daniele, Adlestein Elizabeth, Li Yi, Frejat Sumar, Castro Alvarez Isabel, Alsaloum Marissa, Wu Woon, Reuter Maria, Sherrid Mark
Keywords: Hypertrophic cardiomyopathy , Outcomes