American Heart Association
Predicting and Treating Genetic Cardiomyopathies
Abstract Poster Board Session
Basic Science Zone
Nov 9th , 11:30 AM - 12:30 PM
11 : 30 AM
Genetic Variants Drive Phenotypic Diversity and Adverse Outcomes in Left Ventricular Hypertrabeculation
Yang Kun-qi, Fan Peng, Hu Yuxiao, Kong Dan, Chen Liang, Yin Weihua, Lin Yahui, Li Xiaoni, Lu Peipei, Zhang Xinmin, Wang Tianjie, Wang Yong, Sun Yuqing, Zhang Bo, Ma Menghuai, Li Jing-hui, Xi Shaozhi, Wang Chi, Xu Haobo, Zhu Fasheng, Maimaiti Xier, Wang Huanghuang, Guan Hao, Gao Lijian, Yuan Jiansong, Ma Lihong, Gao Ling-gen, Zhu Da, Zhang Yaohua, Qin Xiuchuan, Hu Aihua, Zhou Xianliang, Duru Firat, Yang Weixian, Tian Tao
Final Pr. ID: Su4008
Authors: Yang Kun-qi, Fan Peng, Hu Yuxiao, Kong Dan, Chen Liang, Yin Weihua, Lin Yahui, Li Xiaoni, Lu Peipei, Zhang Xinmin, Wang Tianjie, Wang Yong, Sun Yuqing, Zhang Bo, Ma Menghuai, Li Jing-hui, Xi Shaozhi, Wang Chi, Xu Haobo, Zhu Fasheng, Maimaiti Xier, Wang Huanghuang, Guan Hao, Gao Lijian, Yuan Jiansong, Ma Lihong, Gao Ling-gen, Zhu Da, Zhang Yaohua, Qin Xiuchuan, Hu Aihua, Zhou Xianliang, Duru Firat, Yang Weixian, Tian Tao
Keywords: Gene mutations , Genetic testing , Left Ventricular , Outcomes
11 : 30 AM
Comprehensive Plasma Transcriptomics Profiling Identifies a Small Set of Circulating MicroRNA Biomarkers to Distinguish Hypertrophic Cardiomyopathy from Other Cardiomyopathies with Left Ventricular Hypertrophy
Kiyohara Yuko, Akita Keitaro, Fifer Michael, Teruya Sergio, Bampatsias Dimitrios, Mirabal Alfonsina, Maurer Mathew, Shimada Yuichi
Final Pr. ID: Su4009
Authors: Kiyohara Yuko, Akita Keitaro, Fifer Michael, Teruya Sergio, Bampatsias Dimitrios, Mirabal Alfonsina, Maurer Mathew, Shimada Yuichi
Keywords: Hypertrophic cardiomyopathy , MicroRNA , Biomarkers
11 : 30 AM
Polygenic score analyses in a large multinational HCM clinical cohort identifies effects on disease penetrance and severity
Jorda Paloma, Lipov Alex, Gimeno Blanes Juan Ramon, Castillo Ismael, Walsh Roddy, Poel Edwin, Moussa Samuel, Haydarlou Poeya, Baas Annette, Michels Michelle, Christiaans Imke, Paterson Natasha, Houweling Arjan, Tremblay-gravel Maxime, Garceau Patrick, Lallier Philippe, Khan Habib, Roston Thomas, Steinberg Christian, Olivotto Iacopo, Barriales Roberto, Jurgens Sean, Cadrin-tourigny Julia, Tanck Michael, Amin A.s., Adler Arnon, Tadros Rafik, Bezzina Connie
Final Pr. ID: Su4010
Authors: Jorda Paloma, Lipov Alex, Gimeno Blanes Juan Ramon, Castillo Ismael, Walsh Roddy, Poel Edwin, Moussa Samuel, Haydarlou Poeya, Baas Annette, Michels Michelle, Christiaans Imke, Paterson Natasha, Houweling Arjan, Tremblay-gravel Maxime, Garceau Patrick, Lallier Philippe, Khan Habib, Roston Thomas, Steinberg Christian, Olivotto Iacopo, Barriales Roberto, Jurgens Sean, Cadrin-tourigny Julia, Tanck Michael, Amin A.s., Adler Arnon, Tadros Rafik, Bezzina Connie
Keywords: Hypertrophic cardiomyopathy , Polygenic Risk , Genomics , Genome-wide association studies (GWAS) , Prognostic model
11 : 30 AM
The Artificial Intelligence-Derived Electrocardiographic Age Gap is Associated with Adverse Clinical Outcomes in Cardiac Laminopathy
Castrichini Matteo, Sularz Agata, Garmany Ramin, Tester David, Bos Johan, Attia Zachi, Noseworthy Peter, Friedman Paul, Lopez-jimenez Francisco, Ackerman Michael, Milone Margherita, Giudicessi John
Final Pr. ID: Su4011
Authors: Castrichini Matteo, Sularz Agata, Garmany Ramin, Tester David, Bos Johan, Attia Zachi, Noseworthy Peter, Friedman Paul, Lopez-jimenez Francisco, Ackerman Michael, Milone Margherita, Giudicessi John
Keywords: Genetics , Artificial Intelligence , Aging , Electrocardiography , Cardiomyopathy
Rand Soren, Bundgaard Johan, Small Aeron, Zheng Chaoqun, Teumer Alexander, Ramachandran Vasan, Dörr Marcus, Consortium Echogen, Moller Jacob, Linde Jesper, Natarajan Pradeep, Ghouse Jonas, Bundgaard Henning
Final Pr. ID: Su4012
Authors: Rand Soren, Bundgaard Johan, Small Aeron, Zheng Chaoqun, Teumer Alexander, Ramachandran Vasan, Dörr Marcus, Consortium Echogen, Moller Jacob, Linde Jesper, Natarajan Pradeep, Ghouse Jonas, Bundgaard Henning
Keywords: Diastolic function , Genome-wide association studies (GWAS)
11 : 30 AM
Patient-specific IPSC-derived Cardiomyocyte Phenotypes Reflect Clinical Variation Within a Family With FLNC Cardiomyopathy
Koehring Ci, Argenziano Mariana, Siddiq Faiza, Higgins Brett, Keller Thomas, Mcdonald Thomas
Final Pr. ID: Su4013
Authors: Koehring Ci, Argenziano Mariana, Siddiq Faiza, Higgins Brett, Keller Thomas, Mcdonald Thomas
Keywords: Gene mutations , Cardiomyopathy , Stem cells , Family , Contractile proteins
11 : 30 AM
LMNAR541C Mutation Lead to Dysregulation in Metabolism and Proliferation Pathways in Cardiomyocytes
Keller Thomas, Koehring Ci, Higgins Brett, Yang Jiajia, Siddiq Faiza, Mcdonald Thomas
Final Pr. ID: Su4014
Authors: Keller Thomas, Koehring Ci, Higgins Brett, Yang Jiajia, Siddiq Faiza, Mcdonald Thomas
Keywords: Gene mutations , Cardiomyopathy , Family , Stem cells , Transcriptomics
11 : 30 AM
Gene Expression Profiles in Patient Specific IPSC-Derived Cardiomyocytes and Cardiac Fibroblasts with Laminopathies Across Diverse Patient Phenotypes
Higgins Brett, Koehring Ci, Siddiq Faiza, Yang Jiajia, Keller Thomas, Mcdonald Thomas
Final Pr. ID: Su4015
Authors: Higgins Brett, Koehring Ci, Siddiq Faiza, Yang Jiajia, Keller Thomas, Mcdonald Thomas
Keywords: Gene mutations , Cardiomyopathy , Family , Stem cells
11 : 30 AM
Dilated Cardiomyopathy and Heart Failure in an Infant due to an Intronic Deletion Disrupting TAZ Splicing
Goraya Sayhaan, Dellefave-castillo Lisa, Page Patrick, Kwon Jason, Stachowski Marisa, Puckelwartz Megan, Mcnally Elizabeth
Final Pr. ID: Su4016
Authors: Goraya Sayhaan, Dellefave-castillo Lisa, Page Patrick, Kwon Jason, Stachowski Marisa, Puckelwartz Megan, Mcnally Elizabeth
Keywords: Gene mutations
Liu Wen, Guo Junli
Final Pr. ID: Su4017
Authors: Liu Wen, Guo Junli
Keywords: Cardiomyopathy , Heart failure
11 : 30 AM
Comprehensive Plasma Transcriptomics Profiling Identifies a Small Set of Circulating MicroRNA Biomarkers to Distinguish Hypertrophic Cardiomyopathy from Other Cardiomyopathies with Left Ventricular Hypertrophy
Kiyohara Yuko, Akita Keitaro, Fifer Michael, Teruya Sergio, Bampatsias Dimitrios, Mirabal Alfonsina, Maurer Mathew, Shimada Yuichi
Final Pr. ID: Su4009
Authors: Kiyohara Yuko, Akita Keitaro, Fifer Michael, Teruya Sergio, Bampatsias Dimitrios, Mirabal Alfonsina, Maurer Mathew, Shimada Yuichi
Keywords: Hypertrophic cardiomyopathy , MicroRNA , Biomarkers
11 : 30 AM
Dilated Cardiomyopathy and Heart Failure in an Infant due to an Intronic Deletion Disrupting TAZ Splicing
Goraya Sayhaan, Dellefave-castillo Lisa, Page Patrick, Kwon Jason, Stachowski Marisa, Puckelwartz Megan, Mcnally Elizabeth
Final Pr. ID: Su4016
Authors: Goraya Sayhaan, Dellefave-castillo Lisa, Page Patrick, Kwon Jason, Stachowski Marisa, Puckelwartz Megan, Mcnally Elizabeth
Keywords: Gene mutations
11 : 30 AM
Gene Expression Profiles in Patient Specific IPSC-Derived Cardiomyocytes and Cardiac Fibroblasts with Laminopathies Across Diverse Patient Phenotypes
Higgins Brett, Koehring Ci, Siddiq Faiza, Yang Jiajia, Keller Thomas, Mcdonald Thomas
Final Pr. ID: Su4015
Authors: Higgins Brett, Koehring Ci, Siddiq Faiza, Yang Jiajia, Keller Thomas, Mcdonald Thomas
Keywords: Gene mutations , Cardiomyopathy , Family , Stem cells
Rand Soren, Bundgaard Johan, Small Aeron, Zheng Chaoqun, Teumer Alexander, Ramachandran Vasan, Dörr Marcus, Consortium Echogen, Moller Jacob, Linde Jesper, Natarajan Pradeep, Ghouse Jonas, Bundgaard Henning
Final Pr. ID: Su4012
Authors: Rand Soren, Bundgaard Johan, Small Aeron, Zheng Chaoqun, Teumer Alexander, Ramachandran Vasan, Dörr Marcus, Consortium Echogen, Moller Jacob, Linde Jesper, Natarajan Pradeep, Ghouse Jonas, Bundgaard Henning
Keywords: Diastolic function , Genome-wide association studies (GWAS)
11 : 30 AM
Genetic Variants Drive Phenotypic Diversity and Adverse Outcomes in Left Ventricular Hypertrabeculation
Yang Kun-qi, Fan Peng, Hu Yuxiao, Kong Dan, Chen Liang, Yin Weihua, Lin Yahui, Li Xiaoni, Lu Peipei, Zhang Xinmin, Wang Tianjie, Wang Yong, Sun Yuqing, Zhang Bo, Ma Menghuai, Li Jing-hui, Xi Shaozhi, Wang Chi, Xu Haobo, Zhu Fasheng, Maimaiti Xier, Wang Huanghuang, Guan Hao, Gao Lijian, Yuan Jiansong, Ma Lihong, Gao Ling-gen, Zhu Da, Zhang Yaohua, Qin Xiuchuan, Hu Aihua, Zhou Xianliang, Duru Firat, Yang Weixian, Tian Tao
Final Pr. ID: Su4008
Authors: Yang Kun-qi, Fan Peng, Hu Yuxiao, Kong Dan, Chen Liang, Yin Weihua, Lin Yahui, Li Xiaoni, Lu Peipei, Zhang Xinmin, Wang Tianjie, Wang Yong, Sun Yuqing, Zhang Bo, Ma Menghuai, Li Jing-hui, Xi Shaozhi, Wang Chi, Xu Haobo, Zhu Fasheng, Maimaiti Xier, Wang Huanghuang, Guan Hao, Gao Lijian, Yuan Jiansong, Ma Lihong, Gao Ling-gen, Zhu Da, Zhang Yaohua, Qin Xiuchuan, Hu Aihua, Zhou Xianliang, Duru Firat, Yang Weixian, Tian Tao
Keywords: Gene mutations , Genetic testing , Left Ventricular , Outcomes
11 : 30 AM
LMNAR541C Mutation Lead to Dysregulation in Metabolism and Proliferation Pathways in Cardiomyocytes
Keller Thomas, Koehring Ci, Higgins Brett, Yang Jiajia, Siddiq Faiza, Mcdonald Thomas
Final Pr. ID: Su4014
Authors: Keller Thomas, Koehring Ci, Higgins Brett, Yang Jiajia, Siddiq Faiza, Mcdonald Thomas
Keywords: Gene mutations , Cardiomyopathy , Family , Stem cells , Transcriptomics
11 : 30 AM
Patient-specific IPSC-derived Cardiomyocyte Phenotypes Reflect Clinical Variation Within a Family With FLNC Cardiomyopathy
Koehring Ci, Argenziano Mariana, Siddiq Faiza, Higgins Brett, Keller Thomas, Mcdonald Thomas
Final Pr. ID: Su4013
Authors: Koehring Ci, Argenziano Mariana, Siddiq Faiza, Higgins Brett, Keller Thomas, Mcdonald Thomas
Keywords: Gene mutations , Cardiomyopathy , Stem cells , Family , Contractile proteins
11 : 30 AM
Polygenic score analyses in a large multinational HCM clinical cohort identifies effects on disease penetrance and severity
Jorda Paloma, Lipov Alex, Gimeno Blanes Juan Ramon, Castillo Ismael, Walsh Roddy, Poel Edwin, Moussa Samuel, Haydarlou Poeya, Baas Annette, Michels Michelle, Christiaans Imke, Paterson Natasha, Houweling Arjan, Tremblay-gravel Maxime, Garceau Patrick, Lallier Philippe, Khan Habib, Roston Thomas, Steinberg Christian, Olivotto Iacopo, Barriales Roberto, Jurgens Sean, Cadrin-tourigny Julia, Tanck Michael, Amin A.s., Adler Arnon, Tadros Rafik, Bezzina Connie
Final Pr. ID: Su4010
Authors: Jorda Paloma, Lipov Alex, Gimeno Blanes Juan Ramon, Castillo Ismael, Walsh Roddy, Poel Edwin, Moussa Samuel, Haydarlou Poeya, Baas Annette, Michels Michelle, Christiaans Imke, Paterson Natasha, Houweling Arjan, Tremblay-gravel Maxime, Garceau Patrick, Lallier Philippe, Khan Habib, Roston Thomas, Steinberg Christian, Olivotto Iacopo, Barriales Roberto, Jurgens Sean, Cadrin-tourigny Julia, Tanck Michael, Amin A.s., Adler Arnon, Tadros Rafik, Bezzina Connie
Keywords: Hypertrophic cardiomyopathy , Polygenic Risk , Genomics , Genome-wide association studies (GWAS) , Prognostic model
11 : 30 AM
The Artificial Intelligence-Derived Electrocardiographic Age Gap is Associated with Adverse Clinical Outcomes in Cardiac Laminopathy
Castrichini Matteo, Sularz Agata, Garmany Ramin, Tester David, Bos Johan, Attia Zachi, Noseworthy Peter, Friedman Paul, Lopez-jimenez Francisco, Ackerman Michael, Milone Margherita, Giudicessi John
Final Pr. ID: Su4011
Authors: Castrichini Matteo, Sularz Agata, Garmany Ramin, Tester David, Bos Johan, Attia Zachi, Noseworthy Peter, Friedman Paul, Lopez-jimenez Francisco, Ackerman Michael, Milone Margherita, Giudicessi John
Keywords: Genetics , Artificial Intelligence , Aging , Electrocardiography , Cardiomyopathy
Liu Wen, Guo Junli
Final Pr. ID: Su4017
Authors: Liu Wen, Guo Junli
Keywords: Cardiomyopathy , Heart failure