American Heart Association
Mechanisms and Modulation of Cardiomyopathy and Diastolic Dysfunction
Moderated Digital Poster Session
Basic Science Zone, Moderated Digital Poster 25
Nov 10th , 09:15 AM - 10:30 AM
09 : 15 AM
Unique Insights into the Pathobiology of TNNI3 Cardiomyopathy using Novel Murine and Porcine Models of Disease
Silver Elizabeth, Telugu Bhanu, Geddes Claire, Adler Eric, Gunes Betul, Fenwick Axel, Bushway Paul, Cammarato Anthony, Simpson Sean, Park Ki-eun, Waters Jerel, Tharp Darla
Final Pr. ID: MP2705
Authors: Silver Elizabeth, Telugu Bhanu, Geddes Claire, Adler Eric, Gunes Betul, Fenwick Axel, Bushway Paul, Cammarato Anthony, Simpson Sean, Park Ki-eun, Waters Jerel, Tharp Darla
Keywords: Hypertrophic cardiomyopathy , Myofilaments , Inflammation
09 : 22 AM
Redox Mediated Dysregulation of Sarcomere Proteins Impairs Cardiac Relaxation in a Murine Model of Preeclampsia
Dulce Raul, Balkan Wayne, Hare Joshua, Kulandavelu Shathiyah
Final Pr. ID: MP2706
Authors: Dulce Raul, Balkan Wayne, Hare Joshua, Kulandavelu Shathiyah
Keywords: Pregnancy , Pre-Eclampsia , Nitric oxide , Excitation-contraction coupling (ECC) , Antioxidant
09 : 29 AM
Mechanisms of Heart Failure Induced by Myofilament Mutations: Disruption of mRNA Stability and Expression ?
Tong Carl, Hale Joshua, Mcalister Lilly, Abdel-rahim Laila, Sheikh Farah
Final Pr. ID: MP2707
Authors: Tong Carl, Hale Joshua, Mcalister Lilly, Abdel-rahim Laila, Sheikh Farah
Keywords: Contractile proteins , Heart failure , Cardiomyopathy , Gene expression , Diastolic function
Blandin Camille, Trembley Michael, Ma Qing, Saifee Shaila, Chen Jiehui, Pu William
Final Pr. ID: MP2708
Authors: Blandin Camille, Trembley Michael, Ma Qing, Saifee Shaila, Chen Jiehui, Pu William
Keywords: Heart failure , pediatric , Cardiovascular disease , Ventricular arrhythmia
09 : 43 AM
A "non-muscle" alpha-actinin is an intrinsic component of the cardiac Z-disc and regulates sarcomere turnover, contractility, and heart remodeling
Hayes James, Smart Kyra, Choudhary Dharmendra, Reinhart-king Cynthia, Liu Qi, Tyska Matthew, Tabdanov Erdem, Wells Quinn, Knapik Ela, Burnette Dylan, Ritter Dylan, Neininger-castro Abigail, Willet Alaina, Caplan Leah, Wang Yu, Liu Xiao, Taneja Nilay, Sanchez Zachary
Final Pr. ID: MP2709
Authors: Hayes James, Smart Kyra, Choudhary Dharmendra, Reinhart-king Cynthia, Liu Qi, Tyska Matthew, Tabdanov Erdem, Wells Quinn, Knapik Ela, Burnette Dylan, Ritter Dylan, Neininger-castro Abigail, Willet Alaina, Caplan Leah, Wang Yu, Liu Xiao, Taneja Nilay, Sanchez Zachary
Keywords: Contractility , Hypertrophy , Remodeling , Cells , Molecular biology
09 : 50 AM
β-alanine Supplementation Improves Diastolic Function in Heart Failure with preserved Ejection Fraction
Doelling Benjamin, Chaudhari Mamata, Makhloufi Jamila, Hoetker David, Brittian Kenneth, Nong Yibing, Baba Shahid
Final Pr. ID: MP2710
Authors: Doelling Benjamin, Chaudhari Mamata, Makhloufi Jamila, Hoetker David, Brittian Kenneth, Nong Yibing, Baba Shahid
Keywords: HFpEF , Diastolic function , Peptides
09 : 57 AM
Association of Finerenone Use With Cardiovascular and Renal Outcomes in Patients With HFpEF and CKD: A Propensity-Matched Real-World Comparative Effectiveness Study
Hanif Muhammad, Jaiswal Vikash, Shrestha Abhigan, Knohl Stephen
Final Pr. ID: MP2711
Authors: Hanif Muhammad, Jaiswal Vikash, Shrestha Abhigan, Knohl Stephen
Keywords: Heart failure , Chronic Kidney Disease , Outcomes , Prevention
10 : 04 AM
Modifying the progression of heart failure with preserved ejection fraction (HFpEF) in pigs by a regular exercise regimen; Effects on LV function and structure
Samani Stephanie, Shazly Tarek, Zile Michael, Spinale Francis, Barlow Shayne, Freeburg Lisa, Catherwood Grayson, Churillo Amelia, Jones Traci, Al-soudi Jumanah, Ruiz Ricky, Yigamawano Francesco
Final Pr. ID: MP2712
Authors: Samani Stephanie, Shazly Tarek, Zile Michael, Spinale Francis, Barlow Shayne, Freeburg Lisa, Catherwood Grayson, Churillo Amelia, Jones Traci, Al-soudi Jumanah, Ruiz Ricky, Yigamawano Francesco
Keywords: Hypertrophy , Exercise , HFpEF , Extracellular matrix , Cardiovascular disease
10 : 11 AM
Accelerated Pacing Reverses Ventricular Stiffening in a Rodent Model of Diastolic Dysfunction
Kabir Raihan, Hancock Emmaleigh, Wetzel Melinda, Shrier Julia, Palmer Bradley, Habel Nicole, Caporizzo Matthew
Final Pr. ID: MP2713
Authors: Kabir Raihan, Hancock Emmaleigh, Wetzel Melinda, Shrier Julia, Palmer Bradley, Habel Nicole, Caporizzo Matthew
Keywords: HFpEF , Pacing , Pressure – volume relation , Ventricular remodeling , Myocardium
10 : 18 AM
Left Ventricular Chamber Stiffness Progressively Increases Despite the Normalization of Blood Pressure After Brief Repetitive Left Ventricular Pressure Overload
Graser Luke, Weil Brian, Canty John
Final Pr. ID: MP2714
Authors: Graser Luke, Weil Brian, Canty John
Keywords: Ventricular remodeling , Hypertension , Fibrosis , Hypertrophy
09 : 43 AM
A "non-muscle" alpha-actinin is an intrinsic component of the cardiac Z-disc and regulates sarcomere turnover, contractility, and heart remodeling
Hayes James, Smart Kyra, Choudhary Dharmendra, Reinhart-king Cynthia, Liu Qi, Tyska Matthew, Tabdanov Erdem, Wells Quinn, Knapik Ela, Burnette Dylan, Ritter Dylan, Neininger-castro Abigail, Willet Alaina, Caplan Leah, Wang Yu, Liu Xiao, Taneja Nilay, Sanchez Zachary
Final Pr. ID: MP2709
Authors: Hayes James, Smart Kyra, Choudhary Dharmendra, Reinhart-king Cynthia, Liu Qi, Tyska Matthew, Tabdanov Erdem, Wells Quinn, Knapik Ela, Burnette Dylan, Ritter Dylan, Neininger-castro Abigail, Willet Alaina, Caplan Leah, Wang Yu, Liu Xiao, Taneja Nilay, Sanchez Zachary
Keywords: Contractility , Hypertrophy , Remodeling , Cells , Molecular biology
10 : 11 AM
Accelerated Pacing Reverses Ventricular Stiffening in a Rodent Model of Diastolic Dysfunction
Kabir Raihan, Hancock Emmaleigh, Wetzel Melinda, Shrier Julia, Palmer Bradley, Habel Nicole, Caporizzo Matthew
Final Pr. ID: MP2713
Authors: Kabir Raihan, Hancock Emmaleigh, Wetzel Melinda, Shrier Julia, Palmer Bradley, Habel Nicole, Caporizzo Matthew
Keywords: HFpEF , Pacing , Pressure – volume relation , Ventricular remodeling , Myocardium
09 : 50 AM
β-alanine Supplementation Improves Diastolic Function in Heart Failure with preserved Ejection Fraction
Doelling Benjamin, Chaudhari Mamata, Makhloufi Jamila, Hoetker David, Brittian Kenneth, Nong Yibing, Baba Shahid
Final Pr. ID: MP2710
Authors: Doelling Benjamin, Chaudhari Mamata, Makhloufi Jamila, Hoetker David, Brittian Kenneth, Nong Yibing, Baba Shahid
Keywords: HFpEF , Diastolic function , Peptides
09 : 57 AM
Association of Finerenone Use With Cardiovascular and Renal Outcomes in Patients With HFpEF and CKD: A Propensity-Matched Real-World Comparative Effectiveness Study
Hanif Muhammad, Jaiswal Vikash, Shrestha Abhigan, Knohl Stephen
Final Pr. ID: MP2711
Authors: Hanif Muhammad, Jaiswal Vikash, Shrestha Abhigan, Knohl Stephen
Keywords: Heart failure , Chronic Kidney Disease , Outcomes , Prevention
Blandin Camille, Trembley Michael, Ma Qing, Saifee Shaila, Chen Jiehui, Pu William
Final Pr. ID: MP2708
Authors: Blandin Camille, Trembley Michael, Ma Qing, Saifee Shaila, Chen Jiehui, Pu William
Keywords: Heart failure , pediatric , Cardiovascular disease , Ventricular arrhythmia
10 : 18 AM
Left Ventricular Chamber Stiffness Progressively Increases Despite the Normalization of Blood Pressure After Brief Repetitive Left Ventricular Pressure Overload
Graser Luke, Weil Brian, Canty John
Final Pr. ID: MP2714
Authors: Graser Luke, Weil Brian, Canty John
Keywords: Ventricular remodeling , Hypertension , Fibrosis , Hypertrophy
09 : 29 AM
Mechanisms of Heart Failure Induced by Myofilament Mutations: Disruption of mRNA Stability and Expression ?
Tong Carl, Hale Joshua, Mcalister Lilly, Abdel-rahim Laila, Sheikh Farah
Final Pr. ID: MP2707
Authors: Tong Carl, Hale Joshua, Mcalister Lilly, Abdel-rahim Laila, Sheikh Farah
Keywords: Contractile proteins , Heart failure , Cardiomyopathy , Gene expression , Diastolic function
10 : 04 AM
Modifying the progression of heart failure with preserved ejection fraction (HFpEF) in pigs by a regular exercise regimen; Effects on LV function and structure
Samani Stephanie, Shazly Tarek, Zile Michael, Spinale Francis, Barlow Shayne, Freeburg Lisa, Catherwood Grayson, Churillo Amelia, Jones Traci, Al-soudi Jumanah, Ruiz Ricky, Yigamawano Francesco
Final Pr. ID: MP2712
Authors: Samani Stephanie, Shazly Tarek, Zile Michael, Spinale Francis, Barlow Shayne, Freeburg Lisa, Catherwood Grayson, Churillo Amelia, Jones Traci, Al-soudi Jumanah, Ruiz Ricky, Yigamawano Francesco
Keywords: Hypertrophy , Exercise , HFpEF , Extracellular matrix , Cardiovascular disease
09 : 22 AM
Redox Mediated Dysregulation of Sarcomere Proteins Impairs Cardiac Relaxation in a Murine Model of Preeclampsia
Dulce Raul, Balkan Wayne, Hare Joshua, Kulandavelu Shathiyah
Final Pr. ID: MP2706
Authors: Dulce Raul, Balkan Wayne, Hare Joshua, Kulandavelu Shathiyah
Keywords: Pregnancy , Pre-Eclampsia , Nitric oxide , Excitation-contraction coupling (ECC) , Antioxidant
09 : 15 AM
Unique Insights into the Pathobiology of TNNI3 Cardiomyopathy using Novel Murine and Porcine Models of Disease
Silver Elizabeth, Telugu Bhanu, Geddes Claire, Adler Eric, Gunes Betul, Fenwick Axel, Bushway Paul, Cammarato Anthony, Simpson Sean, Park Ki-eun, Waters Jerel, Tharp Darla
Final Pr. ID: MP2705
Authors: Silver Elizabeth, Telugu Bhanu, Geddes Claire, Adler Eric, Gunes Betul, Fenwick Axel, Bushway Paul, Cammarato Anthony, Simpson Sean, Park Ki-eun, Waters Jerel, Tharp Darla
Keywords: Hypertrophic cardiomyopathy , Myofilaments , Inflammation