American Heart Association
Cutting-Edge Gene and Precision Therapies
Moderated Digital Poster Session
Basic Science Zone, Moderated Digital Poster 26
Nov 8th , 10:45 AM - 11:45 AM
10 : 45 AM
Genetically informed drug targeting of ryanodine receptor type 2 identifies new precision therapeutic candidates for catecholaminergic polymorphic ventricular tachycardia
Monaco Gabrielle, Jeong Pyeong Hwa, Dewars Enya, Michaels Christopher, Balint Brittany, Argueta Portillo Cindy, Herfindahl Bailey, Van Petegem Filip, Hong Jiyong, Landstrom Andrew
Final Pr. ID: MP1120
Authors: Monaco Gabrielle, Jeong Pyeong Hwa, Dewars Enya, Michaels Christopher, Balint Brittany, Argueta Portillo Cindy, Herfindahl Bailey, Van Petegem Filip, Hong Jiyong, Landstrom Andrew
Keywords: Arrhythmias , treatment of , Precision medicine , Dose-response relation , drug , Pathogenetic , Cardiology
Ng Sheng Rong, Wang Audrey, Tukijan Farhana, Murugiah Astley, Tan Liang Thing, Teo Angela, Lee Qian Yi, Tan Hayden, Choy Audrey, Ong Mervyn, Hsu Wan-en, Varsano Giulia, Pomp Oz, Lee John, Tan Yann Chong
Final Pr. ID: MP1121
Authors: Ng Sheng Rong, Wang Audrey, Tukijan Farhana, Murugiah Astley, Tan Liang Thing, Teo Angela, Lee Qian Yi, Tan Hayden, Choy Audrey, Ong Mervyn, Hsu Wan-en, Varsano Giulia, Pomp Oz, Lee John, Tan Yann Chong
Keywords: Gene therapy , Cardiomyopathy , Heart failure
10 : 59 AM
Large-scale genome-wide association meta-analysis and proteome- and transcriptome-wide Mendelian randomization reveal novel therapeutic targets for heart failure
Rasooly Danielle, Peloso Gina, Giambartolomei Claudia, Nicholls Hannah, Liu Chang, Aung Nay, Gravel-pucillo Kai, Ferolito Brian, Dashti Hesam, Wilson Peter, Phillips Lawrence, Kim Kelly, Gaziano Michael, Sun Yan, Casas Juan, Pereira Alexandre, Joseph Jacob
Final Pr. ID: MP1122
Authors: Rasooly Danielle, Peloso Gina, Giambartolomei Claudia, Nicholls Hannah, Liu Chang, Aung Nay, Gravel-pucillo Kai, Ferolito Brian, Dashti Hesam, Wilson Peter, Phillips Lawrence, Kim Kelly, Gaziano Michael, Sun Yan, Casas Juan, Pereira Alexandre, Joseph Jacob
Keywords: Heart failure , Cardiovascular therapeutics , Genomics , Proteomics , Transcriptomics
11 : 06 AM
A transformative LDL cholesterol–lowering in vivo CRISPR gene editing medicine that functionally upregulates LDLR in mice and non-human primates
Newmark Judith, Wrighton Paul, Iovino Salvatore, Amin Parth, Thompson Morgan, Rizal Salu, Bilodeau Maxime, Dong Ruhong, Zhen Wei, Raghav Jimit, Jaskolka Michael, Diner Benjamin, Soman Vikram, Jinadasa Tushare, Apte Ameya, Wu Meng, Bottega Steve, Thakkar Mansi, Agosto Luis, Majithia Deep, Jambard Shreya, Jansson-fritzberg Linnea, Jones Mark, Fletcher Jillian, Weiss Mckenzie, Kaye Emily, Steward Briana, Bochicchio James, Pietrasiewicz Stephen, Marco Rubio Eugenio, Trong Phan Huu, Chander Nisha, Kazemian Mohammadreza, Lam Kieu, Reid Steve, Dinsmore Michael, Teslovich Tanya, Xie Jenny, Gupta Anshul, Burkly Linda
Final Pr. ID: MP1123
Authors: Newmark Judith, Wrighton Paul, Iovino Salvatore, Amin Parth, Thompson Morgan, Rizal Salu, Bilodeau Maxime, Dong Ruhong, Zhen Wei, Raghav Jimit, Jaskolka Michael, Diner Benjamin, Soman Vikram, Jinadasa Tushare, Apte Ameya, Wu Meng, Bottega Steve, Thakkar Mansi, Agosto Luis, Majithia Deep, Jambard Shreya, Jansson-fritzberg Linnea, Jones Mark, Fletcher Jillian, Weiss Mckenzie, Kaye Emily, Steward Briana, Bochicchio James, Pietrasiewicz Stephen, Marco Rubio Eugenio, Trong Phan Huu, Chander Nisha, Kazemian Mohammadreza, Lam Kieu, Reid Steve, Dinsmore Michael, Teslovich Tanya, Xie Jenny, Gupta Anshul, Burkly Linda
Keywords: Atherosclerosis , Cardiovascular disease , Cholesterol-lowering drugs , Gene therapy , Hypercholesterolemia
11 : 13 AM
An Integrative Strategy Combining Genetic, Proteomic, and Clinical Data Identifies Circulating WARS as a Candidate Target for Hypertension.
Chignon Arnaud, Lettre Guillaume
Final Pr. ID: MP1124
Authors: Chignon Arnaud, Lettre Guillaume
Keywords: Hypertension , Genomics , Proteomics , Drugs , Big Data
11 : 20 AM
Integrative Single-Cell and Genetic Profiling of Human Heart Failure for Therapeutic Target Discovery
Bleckwehl Tore, Schumacher David, Amrute Junedh, Hoeft Konrad, Das Vivek, Baumgart Simon, Kramann Rafael, Hayat Sikander
Final Pr. ID: MP1125
Authors: Bleckwehl Tore, Schumacher David, Amrute Junedh, Hoeft Konrad, Das Vivek, Baumgart Simon, Kramann Rafael, Hayat Sikander
Keywords: Myocardial infarction , Genetics , Heart failure , adult , Cardiomyopathy , Transcriptomics
11 : 27 AM
Efficacy and Safety of a Novel AAV FXN Gene Therapy (SGT-212) for the Treatment of Friedreich’s Ataxia
Pavlath Grace, Marshall Jamie, Lee Jun, Harmelink Matthew, Roy Choudhury Gourav, Born Heather, Hordeaux Juliette, Wilson James, Brooks Gabriel, Hanrahan Jessie, Christoforou Nicolas
Final Pr. ID: MP1126
Authors: Pavlath Grace, Marshall Jamie, Lee Jun, Harmelink Matthew, Roy Choudhury Gourav, Born Heather, Hordeaux Juliette, Wilson James, Brooks Gabriel, Hanrahan Jessie, Christoforou Nicolas
Keywords: Gene therapy , Gene transfer , Mitochondria
Khakoo Aarif, Duncan-lewis Christopher, Fernandes Jason, Charles Emeric, Keller Steven, Alcantara-lee Raniel, Santamaria Carlos, Bale Shyam Sundhar, Kozy Heather, Corbo Lana, Narsineni Lokesh, Karmarkar Maitreyee, Li Yuexuan, Krupa Oleh, Bucher Simon, Sharma Neel, Chang Han, Schulwach Keith, Ripley-phipps Sterling, Tran Vanessa, Goh Natalie, Deiter Fred, Reimer Kirsten, Mrak Anna, Eggers Michelle, Sze Christie, Mirotsou Maria, Oresic Bender Kristina, Bardai Farah, Denny Sarah, Oakes Benjamin
Final Pr. ID: MP1127
Authors: Khakoo Aarif, Duncan-lewis Christopher, Fernandes Jason, Charles Emeric, Keller Steven, Alcantara-lee Raniel, Santamaria Carlos, Bale Shyam Sundhar, Kozy Heather, Corbo Lana, Narsineni Lokesh, Karmarkar Maitreyee, Li Yuexuan, Krupa Oleh, Bucher Simon, Sharma Neel, Chang Han, Schulwach Keith, Ripley-phipps Sterling, Tran Vanessa, Goh Natalie, Deiter Fred, Reimer Kirsten, Mrak Anna, Eggers Michelle, Sze Christie, Mirotsou Maria, Oresic Bender Kristina, Bardai Farah, Denny Sarah, Oakes Benjamin
Keywords: Epigenetics , Gene therapy , PCSK9 , Cholesterol-lowering drugs , Atherosclerosis
11 : 06 AM
A transformative LDL cholesterol–lowering in vivo CRISPR gene editing medicine that functionally upregulates LDLR in mice and non-human primates
Newmark Judith, Wrighton Paul, Iovino Salvatore, Amin Parth, Thompson Morgan, Rizal Salu, Bilodeau Maxime, Dong Ruhong, Zhen Wei, Raghav Jimit, Jaskolka Michael, Diner Benjamin, Soman Vikram, Jinadasa Tushare, Apte Ameya, Wu Meng, Bottega Steve, Thakkar Mansi, Agosto Luis, Majithia Deep, Jambard Shreya, Jansson-fritzberg Linnea, Jones Mark, Fletcher Jillian, Weiss Mckenzie, Kaye Emily, Steward Briana, Bochicchio James, Pietrasiewicz Stephen, Marco Rubio Eugenio, Trong Phan Huu, Chander Nisha, Kazemian Mohammadreza, Lam Kieu, Reid Steve, Dinsmore Michael, Teslovich Tanya, Xie Jenny, Gupta Anshul, Burkly Linda
Final Pr. ID: MP1123
Authors: Newmark Judith, Wrighton Paul, Iovino Salvatore, Amin Parth, Thompson Morgan, Rizal Salu, Bilodeau Maxime, Dong Ruhong, Zhen Wei, Raghav Jimit, Jaskolka Michael, Diner Benjamin, Soman Vikram, Jinadasa Tushare, Apte Ameya, Wu Meng, Bottega Steve, Thakkar Mansi, Agosto Luis, Majithia Deep, Jambard Shreya, Jansson-fritzberg Linnea, Jones Mark, Fletcher Jillian, Weiss Mckenzie, Kaye Emily, Steward Briana, Bochicchio James, Pietrasiewicz Stephen, Marco Rubio Eugenio, Trong Phan Huu, Chander Nisha, Kazemian Mohammadreza, Lam Kieu, Reid Steve, Dinsmore Michael, Teslovich Tanya, Xie Jenny, Gupta Anshul, Burkly Linda
Keywords: Atherosclerosis , Cardiovascular disease , Cholesterol-lowering drugs , Gene therapy , Hypercholesterolemia
11 : 13 AM
An Integrative Strategy Combining Genetic, Proteomic, and Clinical Data Identifies Circulating WARS as a Candidate Target for Hypertension.
Chignon Arnaud, Lettre Guillaume
Final Pr. ID: MP1124
Authors: Chignon Arnaud, Lettre Guillaume
Keywords: Hypertension , Genomics , Proteomics , Drugs , Big Data
11 : 27 AM
Efficacy and Safety of a Novel AAV FXN Gene Therapy (SGT-212) for the Treatment of Friedreich’s Ataxia
Pavlath Grace, Marshall Jamie, Lee Jun, Harmelink Matthew, Roy Choudhury Gourav, Born Heather, Hordeaux Juliette, Wilson James, Brooks Gabriel, Hanrahan Jessie, Christoforou Nicolas
Final Pr. ID: MP1126
Authors: Pavlath Grace, Marshall Jamie, Lee Jun, Harmelink Matthew, Roy Choudhury Gourav, Born Heather, Hordeaux Juliette, Wilson James, Brooks Gabriel, Hanrahan Jessie, Christoforou Nicolas
Keywords: Gene therapy , Gene transfer , Mitochondria
10 : 45 AM
Genetically informed drug targeting of ryanodine receptor type 2 identifies new precision therapeutic candidates for catecholaminergic polymorphic ventricular tachycardia
Monaco Gabrielle, Jeong Pyeong Hwa, Dewars Enya, Michaels Christopher, Balint Brittany, Argueta Portillo Cindy, Herfindahl Bailey, Van Petegem Filip, Hong Jiyong, Landstrom Andrew
Final Pr. ID: MP1120
Authors: Monaco Gabrielle, Jeong Pyeong Hwa, Dewars Enya, Michaels Christopher, Balint Brittany, Argueta Portillo Cindy, Herfindahl Bailey, Van Petegem Filip, Hong Jiyong, Landstrom Andrew
Keywords: Arrhythmias , treatment of , Precision medicine , Dose-response relation , drug , Pathogenetic , Cardiology
11 : 20 AM
Integrative Single-Cell and Genetic Profiling of Human Heart Failure for Therapeutic Target Discovery
Bleckwehl Tore, Schumacher David, Amrute Junedh, Hoeft Konrad, Das Vivek, Baumgart Simon, Kramann Rafael, Hayat Sikander
Final Pr. ID: MP1125
Authors: Bleckwehl Tore, Schumacher David, Amrute Junedh, Hoeft Konrad, Das Vivek, Baumgart Simon, Kramann Rafael, Hayat Sikander
Keywords: Myocardial infarction , Genetics , Heart failure , adult , Cardiomyopathy , Transcriptomics
10 : 59 AM
Large-scale genome-wide association meta-analysis and proteome- and transcriptome-wide Mendelian randomization reveal novel therapeutic targets for heart failure
Rasooly Danielle, Peloso Gina, Giambartolomei Claudia, Nicholls Hannah, Liu Chang, Aung Nay, Gravel-pucillo Kai, Ferolito Brian, Dashti Hesam, Wilson Peter, Phillips Lawrence, Kim Kelly, Gaziano Michael, Sun Yan, Casas Juan, Pereira Alexandre, Joseph Jacob
Final Pr. ID: MP1122
Authors: Rasooly Danielle, Peloso Gina, Giambartolomei Claudia, Nicholls Hannah, Liu Chang, Aung Nay, Gravel-pucillo Kai, Ferolito Brian, Dashti Hesam, Wilson Peter, Phillips Lawrence, Kim Kelly, Gaziano Michael, Sun Yan, Casas Juan, Pereira Alexandre, Joseph Jacob
Keywords: Heart failure , Cardiovascular therapeutics , Genomics , Proteomics , Transcriptomics
Ng Sheng Rong, Wang Audrey, Tukijan Farhana, Murugiah Astley, Tan Liang Thing, Teo Angela, Lee Qian Yi, Tan Hayden, Choy Audrey, Ong Mervyn, Hsu Wan-en, Varsano Giulia, Pomp Oz, Lee John, Tan Yann Chong
Final Pr. ID: MP1121
Authors: Ng Sheng Rong, Wang Audrey, Tukijan Farhana, Murugiah Astley, Tan Liang Thing, Teo Angela, Lee Qian Yi, Tan Hayden, Choy Audrey, Ong Mervyn, Hsu Wan-en, Varsano Giulia, Pomp Oz, Lee John, Tan Yann Chong
Keywords: Gene therapy , Cardiomyopathy , Heart failure
Khakoo Aarif, Duncan-lewis Christopher, Fernandes Jason, Charles Emeric, Keller Steven, Alcantara-lee Raniel, Santamaria Carlos, Bale Shyam Sundhar, Kozy Heather, Corbo Lana, Narsineni Lokesh, Karmarkar Maitreyee, Li Yuexuan, Krupa Oleh, Bucher Simon, Sharma Neel, Chang Han, Schulwach Keith, Ripley-phipps Sterling, Tran Vanessa, Goh Natalie, Deiter Fred, Reimer Kirsten, Mrak Anna, Eggers Michelle, Sze Christie, Mirotsou Maria, Oresic Bender Kristina, Bardai Farah, Denny Sarah, Oakes Benjamin
Final Pr. ID: MP1127
Authors: Khakoo Aarif, Duncan-lewis Christopher, Fernandes Jason, Charles Emeric, Keller Steven, Alcantara-lee Raniel, Santamaria Carlos, Bale Shyam Sundhar, Kozy Heather, Corbo Lana, Narsineni Lokesh, Karmarkar Maitreyee, Li Yuexuan, Krupa Oleh, Bucher Simon, Sharma Neel, Chang Han, Schulwach Keith, Ripley-phipps Sterling, Tran Vanessa, Goh Natalie, Deiter Fred, Reimer Kirsten, Mrak Anna, Eggers Michelle, Sze Christie, Mirotsou Maria, Oresic Bender Kristina, Bardai Farah, Denny Sarah, Oakes Benjamin
Keywords: Epigenetics , Gene therapy , PCSK9 , Cholesterol-lowering drugs , Atherosclerosis