Showing Results from 1 to 12 of 32.
Karanth Santhosh, Ripley-phipps Sterling, Miller Katherine, Su Ali, Mrak Anna, Karmarkar Maitreyee, Eggers Michelle, Bardai Farah, Narsineni Lokesh, Li Yuexuan, Langner Heera, Bucher Simon, Szulwach Keith, Goh Natalie, Mok Amanda, Reimer Kirsten, Oakes Benjamin, Khakoo Aarif, Mirotsou Maria, Smekalova Elena, Saraya Jennifer, Stein Shannon, Sato Anna, Bale Shyamsundhar, Krupa Oleh, Mauriello Anthony
Final Pr. ID: 4146303
Authors: Karanth Santhosh , Ripley-phipps Sterling , Miller Katherine , Su Ali , Mrak Anna , Karmarkar Maitreyee , Eggers Michelle , Bardai Farah , Narsineni Lokesh , Li Yuexuan , Langner Heera , Bucher Simon , Szulwach Keith , Goh Natalie , Mok Amanda , Reimer Kirsten , Oakes Benjamin , Khakoo Aarif , Mirotsou Maria , Smekalova Elena , Saraya Jennifer , Stein Shannon , Sato Anna , Bale Shyamsundhar , Krupa Oleh , Mauriello Anthony
Keywords: Lipoproteins, Triglycerides, Gene therapy, Apolipoproteins, Hypertriglyceridemia
04 : 30 PM
Adeno-associated virus-mediated gene delivery of PERM1 enhances cardiac contractility and mitochondrial biogenesis in mice.
Sreedevi Karthi, Doku Abigail Oforiwaa, James Amina, Do Sara, Zaitsev Alexey, Warren Junco
Final Pr. ID: Tu093
Authors: Sreedevi Karthi , Doku Abigail Oforiwaa , James Amina , Do Sara , Zaitsev Alexey , Warren Junco
Keywords: Heart failure, Cardiac metabolism, Mitochondria, Contractility, Gene therapy
07 : 42 AM
Astrocytic Cluster of Differentiation 38 Contributes to Hippocampal Synaptic Plasticity Deficits following Focal Cerebral Ischemia
Jackson Charles, Waits Paxton, Browning Sydney, Orfila James, Herson Paco
Final Pr. ID: 90
Authors: Jackson Charles , Waits Paxton , Browning Sydney , Orfila James , Herson Paco
Keywords: Cellular electrophysiology, Cognitive impairment, Transgenic models, Gene therapy, Ischemic stroke
02 : 00 PM
Cardiac Favored Transcription of the Exogenous Gene in Mice after A Single Systemic Delivery of AAV9-cBIN1
Ha Thuy, Li Jing, Balmaceda Pia, Shaw Robin, Hong Tingting
Final Pr. ID: Sa1096
Authors: Ha Thuy , Li Jing , Balmaceda Pia , Shaw Robin , Hong Tingting
Keywords: Gene therapy, Heart failure, Gene expression, Pharmacokinetics
02 : 00 PM
Cardiac specific gene therapy to treat diabetic heart failure with preserved ejection fraction
Guo Yugene, Liu Hong, Kang Gyeoung-jin, Liu Man, Butler Jonah, Dudley Samuel
Final Pr. ID: Sa2167
Authors: Guo Yugene , Liu Hong , Kang Gyeoung-jin , Liu Man , Butler Jonah , Dudley Samuel
Keywords: Gene therapy, Heart failure, Diabetes (Type II), Diastolic function, Inflammation
04 : 30 PM
Cardioactive molecules identified by functional in vivo screening prevent anthracycline cardiotoxicity
Bortolotti Francesca, Mura Antonio, Riccio Matteo Maria, Dal Ferro Matteo, Zentilin Lorena, Giacca Mauro
Final Pr. ID: Mo014
Authors: Bortolotti Francesca , Mura Antonio , Riccio Matteo Maria , Dal Ferro Matteo , Zentilin Lorena , Giacca Mauro
Keywords: Cardio-oncology, Apoptosis, Autophagy, Gene therapy, Cardiomyopathy
03 : 40 PM
Cardiomyocyte-specific PLCe1 knock-down attenuates Angiotensin II-induced cardiac hypertrophy.
Ni Kareemah, Rigaud Vagner, Vigneault Patrick, Xiao Chunyang, Klattenhoff Carla, Ellinor Patrick
Final Pr. ID: MDP127
Authors: Ni Kareemah , Rigaud Vagner , Vigneault Patrick , Xiao Chunyang , Klattenhoff Carla , Ellinor Patrick
Keywords: Hypertrophic cardiomyopathy, Gene therapy, Cardiac hypertrophy, Angiotensin II, Molecular biology
04 : 30 PM
cBIN1 Gene Therapy Improves Left Ventricular Filling Pressure in a Canine Model of Ischemic Dilated Cardiomyopathy
Khan Muhammad, Shaw Robin, Dosdall Derek, Yazaki Kyoichiro, Ishidoya Yuki, Offei Emmanuel, Ruizcastillo Sofia, Shah Ankur, Li Jing, Palatinus Joseph, Hong Tingting
Final Pr. ID: We105
Authors: Khan Muhammad , Shaw Robin , Dosdall Derek , Yazaki Kyoichiro , Ishidoya Yuki , Offei Emmanuel , Ruizcastillo Sofia , Shah Ankur , Li Jing , Palatinus Joseph , Hong Tingting
Keywords: Gene therapy, Ischemic heart disease, Ventricular remodeling, Myocardial infarction, Pressure volume relation
01 : 20 PM
CRISPR screening identifies critical factors regulating DNA damage response in human cardiomyocytes under oxidative stress
Kubota Masayuki, Ito Masamichi, Nomura Seitaro, Takeda Norihiko, Komuro Issei
Final Pr. ID: MDP84
Authors: Kubota Masayuki , Ito Masamichi , Nomura Seitaro , Takeda Norihiko , Komuro Issei
Keywords: Heart failure, Precision medicine, Gene therapy, Cardiovascular disease
09 : 45 AM
Danon Disease Phase 1 RP-A501 Results: The First Single-Dose Intravenous Gene Therapy with Recombinant Adeno-Associated Virus (AAV9:LAMP2B) for a Monogenic Cardiomyopathy
Greenberg Barry, Coggins Matthew, Schwartz Jonathan, Rossano Joseph, Taylor Matthew, Colan Steven, Adler Eric, Ricks David, Yarabe Paul, Battiprolu Pavan, Shah Guarav, Patel Kinnari
Final Pr. ID: 4168378
Authors: Greenberg Barry , Coggins Matthew , Schwartz Jonathan , Rossano Joseph , Taylor Matthew , Colan Steven , Adler Eric , Ricks David , Yarabe Paul , Battiprolu Pavan , Shah Guarav , Patel Kinnari
Keywords: Gene therapy, Hypertrophic cardiomyopathy, Clinical trials, Outcomes, Cardiomyopathy
10 : 35 AM
Design of Heart-2: a phase 1b clinical trial of VERVE-102, an in vivo base editing medicine delivered by a GalNAc-LNP and targeting PCSK9 to durably lower LDL cholesterol
Vafai Scott, Fiedorek Fred, Karsten Verena, Jensen Chelsey, Falzone Richard, Lister Troy, Stolz Leslie, Khera Amit, Kathiresan Sekar, Bellinger Andrew
Final Pr. ID: MDP40
Authors: Vafai Scott , Fiedorek Fred , Karsten Verena , Jensen Chelsey , Falzone Richard , Lister Troy , Stolz Leslie , Khera Amit , Kathiresan Sekar , Bellinger Andrew
Keywords: Gene therapy, Hypercholesterolemia, Atherosclerosis, Lipids, Targeted therapeutics
04 : 30 PM
Efficient Intramyocardial Delivery of EV-Encapsulated AAVs to Target Cardiomyocytes in a Pre-Clinical Swine Model
Gallinat Alex, Sahoo Susmita, La Salvia Sabrina, Li Xisheng, Raisinghani Nikhil, Zhang Shihong, Shao Alan, Phan Anh, Mavropoulos Spyros, Ishikawa Kiyotake
Final Pr. ID: Tu008
Authors: Gallinat Alex , Sahoo Susmita , La Salvia Sabrina , Li Xisheng , Raisinghani Nikhil , Zhang Shihong , Shao Alan , Phan Anh , Mavropoulos Spyros , Ishikawa Kiyotake
Keywords: Gene therapy, Gene transfer, Myocardium