American Heart Association
Precision Interventions for the Failing Heart: Genetic, Metabolic, and Immune Frontiers
Abstract Poster Board Session
Basic Science Zone
Nov 8th , 02:30 PM - 03:30 PM
02 : 30 PM
DNMT3B-Mediated Epigenetic Reprogramming Induces Cardiomyocyte Dedifferentiation and Proliferation, Enhancing Post-MI Cardiac Regeneration
Gurrala Charan, Cohen Maddy, Kubo Hajime, Joladarashi Darukeshwara, Abraham Elizabeth, Mallaredy Vandana, Cheng Zhongjian, Mcmullan Elena, Wittmann Christopher, Thakur Abhimanyu, Cimini Maria, Truongcao May, Natarajaseenivasan Suriya Muthukumaran, Benedict Cindy, Ghosh Jayashri, Garikipati Venkata, Estaras Conchi, Kishore Raj
Final Pr. ID: LBP3
Authors: Gurrala Charan, Cohen Maddy, Kubo Hajime, Joladarashi Darukeshwara, Abraham Elizabeth, Mallaredy Vandana, Cheng Zhongjian, Mcmullan Elena, Wittmann Christopher, Thakur Abhimanyu, Cimini Maria, Truongcao May, Natarajaseenivasan Suriya Muthukumaran, Benedict Cindy, Ghosh Jayashri, Garikipati Venkata, Estaras Conchi, Kishore Raj
Keywords: Epigenetics , Remodeling , Myocardial infarction
Qin Zihan, Haftbaradaran Esfahani Payam, Pawelzik Sven-christian, Bosman Matthias, Bergstrom Goran, Guns Pieter-jan, Franco-cereceda Anders, Back Magnus
Final Pr. ID: LBP5
Authors: Qin Zihan, Haftbaradaran Esfahani Payam, Pawelzik Sven-christian, Bosman Matthias, Bergstrom Goran, Guns Pieter-jan, Franco-cereceda Anders, Back Magnus
Keywords: Aortic valve stenosis , Calcification , Lipids , Oxidative Stress , Hemorrhage
02 : 30 PM
Exosome-loaded with Small Cajal Body Associated RNA20: A Novel Therapeutic Strategy for Cardiovascular Disease
Rajasingh Sheeja, Vembuli Hemanathan, Johnson Rajasingh
Final Pr. ID: LBP6
Authors: Rajasingh Sheeja, Vembuli Hemanathan, Johnson Rajasingh
Keywords: Tissue engineering , Stem cell therapy , Stem cells , Cardiovascular therapeutics , Cardiac regeneration
02 : 30 PM
Danicamtiv, a Novel Direct Enhancer of Cardiac Myosin Motor Function, Improves Cardiac Performance and Output in the setting of Myosin Dysfunction: In vitro and In vivo Evidence.
Anto Anu, Mohran Saffie, Zambartaro Christopher, Papadaki Maria, Sa Na, Geist Gail, Roof Steve, Falero Shane, Ueyama Yukie, Rodriguez Hector, Maya Juan, Ballard Victoria, Del Rio Carlos
Final Pr. ID: LBP8
Authors: Anto Anu, Mohran Saffie, Zambartaro Christopher, Papadaki Maria, Sa Na, Geist Gail, Roof Steve, Falero Shane, Ueyama Yukie, Rodriguez Hector, Maya Juan, Ballard Victoria, Del Rio Carlos
Keywords: Cardiovascular therapeutics , Cardiomyopathy , Muscle , cardiac - see Myocardium , Targeted therapeutics
Gaither Jeffrey, Moreland Blythe, Garg Vidu, White Peter
Final Pr. ID: LBP16
Authors: Gaither Jeffrey, Moreland Blythe, Garg Vidu, White Peter
Keywords: Congenital heart disease , Precision medicine , Genomics , Machine Learning
Kremer Nils, Thal Bruno, Janetzko Patrick, Yogeswaran Athiththan, Rako Zvonimir, Pullamsetti Soni, Bonnet Sebastien, Seeger Werner, Grimminger Friedrich, Naeije Robert, Ghofrani Ardeschir, Tello Khodr
Final Pr. ID: LBP18
Authors: Kremer Nils, Thal Bruno, Janetzko Patrick, Yogeswaran Athiththan, Rako Zvonimir, Pullamsetti Soni, Bonnet Sebastien, Seeger Werner, Grimminger Friedrich, Naeije Robert, Ghofrani Ardeschir, Tello Khodr
Keywords: Pulmonary hypertension , Right Ventricular Dysfunction , Monitoring , physiologic , Drugs , Prostacyclin
02 : 30 PM
A human cardiomyocyte model of CD36 haploinsufficiency uncovers fatty acid oxidation deficits driving dilated cardiomyopathy
Al Sayed Zeina, Willcox Jon, Zheng Alice, Koledova Vera, Srivastava Salil, Yin Xiaofei, Chaffin Mark, Rigaud Vagner, Kovacs-bogdan Erika, Klattenhoff Carla, Aragam Krishna, Ellinor Patrick
Final Pr. ID: LBP21
Authors: Al Sayed Zeina, Willcox Jon, Zheng Alice, Koledova Vera, Srivastava Salil, Yin Xiaofei, Chaffin Mark, Rigaud Vagner, Kovacs-bogdan Erika, Klattenhoff Carla, Aragam Krishna, Ellinor Patrick
Keywords: Cardiomyopathy , Metabolism , Lipids , Ethnicity , Mitochondria
02 : 30 PM
ATOH8 drives fibrotic remodeling in the human heart as a molecular regulator – a single-cell based validation approach of a potential therapeutic target in cardiac fibrosis
Moeller Christian, Schumacher David, Kramann Rafael
Final Pr. ID: LBP22
Authors: Moeller Christian, Schumacher David, Kramann Rafael
Keywords: Heart failure , Fibrosis , Transcriptomics , Cell signaling , Genomics
02 : 30 PM
A Highly Selective and Orally Available HDAC6 Inhibitor, EKZ-102, Ameliorates Cardiac Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF
Elbatreek Mahmoud, Evans Lauren, Richardson Thomas, James Rebecca, Schroeder Frederick, Wang Jianhong, Luterman Jim, Gilbert Tonya, Fisher Richard, Goodchild Traci, Lefer David
Final Pr. ID: LBP24
Authors: Elbatreek Mahmoud, Evans Lauren, Richardson Thomas, James Rebecca, Schroeder Frederick, Wang Jianhong, Luterman Jim, Gilbert Tonya, Fisher Richard, Goodchild Traci, Lefer David
Keywords: Heart failure , HFpEF , Cardiomyopathy
02 : 30 PM
Early Systemic Immune Response After Cardiac Arrest and The Immunomodulatory and Neuroprotective Effects of LPC(22:6)
Espin Blanca, Kazmi Jacob, Tahavvori Amir, Singh Parmeshar, Sharma Arjun, Becker Lance, Kim Junhwan
Final Pr. ID: LBP25
Authors: Espin Blanca, Kazmi Jacob, Tahavvori Amir, Singh Parmeshar, Sharma Arjun, Becker Lance, Kim Junhwan
Keywords: Immunologic techniques , Cardiac arrest
02 : 30 PM
A mechanism whereby SGLT2 inhibitor dapagliflozin reverses cardiac diastolic dysfunction in a model of HFpEF
Liu Man, Liu Hong, Kang Gyeoung-jin, Kim Eunji, Neumann Mitchell, Johnson Madeline, Murikinati Ruthvika, Dudley Samuel
Final Pr. ID: LBP27
Authors: Liu Man, Liu Hong, Kang Gyeoung-jin, Kim Eunji, Neumann Mitchell, Johnson Madeline, Murikinati Ruthvika, Dudley Samuel
Keywords: HFpEF , Cardioprotective drugs , Diastolic function , Inflammation , Membrane transporters
02 : 30 PM
A Highly Selective and Orally Available HDAC6 Inhibitor, EKZ-102, Ameliorates Cardiac Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF
Elbatreek Mahmoud, Evans Lauren, Richardson Thomas, James Rebecca, Schroeder Frederick, Wang Jianhong, Luterman Jim, Gilbert Tonya, Fisher Richard, Goodchild Traci, Lefer David
Final Pr. ID: LBP24
Authors: Elbatreek Mahmoud, Evans Lauren, Richardson Thomas, James Rebecca, Schroeder Frederick, Wang Jianhong, Luterman Jim, Gilbert Tonya, Fisher Richard, Goodchild Traci, Lefer David
Keywords: Heart failure , HFpEF , Cardiomyopathy
02 : 30 PM
A human cardiomyocyte model of CD36 haploinsufficiency uncovers fatty acid oxidation deficits driving dilated cardiomyopathy
Al Sayed Zeina, Willcox Jon, Zheng Alice, Koledova Vera, Srivastava Salil, Yin Xiaofei, Chaffin Mark, Rigaud Vagner, Kovacs-bogdan Erika, Klattenhoff Carla, Aragam Krishna, Ellinor Patrick
Final Pr. ID: LBP21
Authors: Al Sayed Zeina, Willcox Jon, Zheng Alice, Koledova Vera, Srivastava Salil, Yin Xiaofei, Chaffin Mark, Rigaud Vagner, Kovacs-bogdan Erika, Klattenhoff Carla, Aragam Krishna, Ellinor Patrick
Keywords: Cardiomyopathy , Metabolism , Lipids , Ethnicity , Mitochondria
02 : 30 PM
A mechanism whereby SGLT2 inhibitor dapagliflozin reverses cardiac diastolic dysfunction in a model of HFpEF
Liu Man, Liu Hong, Kang Gyeoung-jin, Kim Eunji, Neumann Mitchell, Johnson Madeline, Murikinati Ruthvika, Dudley Samuel
Final Pr. ID: LBP27
Authors: Liu Man, Liu Hong, Kang Gyeoung-jin, Kim Eunji, Neumann Mitchell, Johnson Madeline, Murikinati Ruthvika, Dudley Samuel
Keywords: HFpEF , Cardioprotective drugs , Diastolic function , Inflammation , Membrane transporters
Kremer Nils, Thal Bruno, Janetzko Patrick, Yogeswaran Athiththan, Rako Zvonimir, Pullamsetti Soni, Bonnet Sebastien, Seeger Werner, Grimminger Friedrich, Naeije Robert, Ghofrani Ardeschir, Tello Khodr
Final Pr. ID: LBP18
Authors: Kremer Nils, Thal Bruno, Janetzko Patrick, Yogeswaran Athiththan, Rako Zvonimir, Pullamsetti Soni, Bonnet Sebastien, Seeger Werner, Grimminger Friedrich, Naeije Robert, Ghofrani Ardeschir, Tello Khodr
Keywords: Pulmonary hypertension , Right Ventricular Dysfunction , Monitoring , physiologic , Drugs , Prostacyclin
Qin Zihan, Haftbaradaran Esfahani Payam, Pawelzik Sven-christian, Bosman Matthias, Bergstrom Goran, Guns Pieter-jan, Franco-cereceda Anders, Back Magnus
Final Pr. ID: LBP5
Authors: Qin Zihan, Haftbaradaran Esfahani Payam, Pawelzik Sven-christian, Bosman Matthias, Bergstrom Goran, Guns Pieter-jan, Franco-cereceda Anders, Back Magnus
Keywords: Aortic valve stenosis , Calcification , Lipids , Oxidative Stress , Hemorrhage
02 : 30 PM
ATOH8 drives fibrotic remodeling in the human heart as a molecular regulator – a single-cell based validation approach of a potential therapeutic target in cardiac fibrosis
Moeller Christian, Schumacher David, Kramann Rafael
Final Pr. ID: LBP22
Authors: Moeller Christian, Schumacher David, Kramann Rafael
Keywords: Heart failure , Fibrosis , Transcriptomics , Cell signaling , Genomics
Gaither Jeffrey, Moreland Blythe, Garg Vidu, White Peter
Final Pr. ID: LBP16
Authors: Gaither Jeffrey, Moreland Blythe, Garg Vidu, White Peter
Keywords: Congenital heart disease , Precision medicine , Genomics , Machine Learning
02 : 30 PM
Danicamtiv, a Novel Direct Enhancer of Cardiac Myosin Motor Function, Improves Cardiac Performance and Output in the setting of Myosin Dysfunction: In vitro and In vivo Evidence.
Anto Anu, Mohran Saffie, Zambartaro Christopher, Papadaki Maria, Sa Na, Geist Gail, Roof Steve, Falero Shane, Ueyama Yukie, Rodriguez Hector, Maya Juan, Ballard Victoria, Del Rio Carlos
Final Pr. ID: LBP8
Authors: Anto Anu, Mohran Saffie, Zambartaro Christopher, Papadaki Maria, Sa Na, Geist Gail, Roof Steve, Falero Shane, Ueyama Yukie, Rodriguez Hector, Maya Juan, Ballard Victoria, Del Rio Carlos
Keywords: Cardiovascular therapeutics , Cardiomyopathy , Muscle , cardiac - see Myocardium , Targeted therapeutics
02 : 30 PM
DNMT3B-Mediated Epigenetic Reprogramming Induces Cardiomyocyte Dedifferentiation and Proliferation, Enhancing Post-MI Cardiac Regeneration
Gurrala Charan, Cohen Maddy, Kubo Hajime, Joladarashi Darukeshwara, Abraham Elizabeth, Mallaredy Vandana, Cheng Zhongjian, Mcmullan Elena, Wittmann Christopher, Thakur Abhimanyu, Cimini Maria, Truongcao May, Natarajaseenivasan Suriya Muthukumaran, Benedict Cindy, Ghosh Jayashri, Garikipati Venkata, Estaras Conchi, Kishore Raj
Final Pr. ID: LBP3
Authors: Gurrala Charan, Cohen Maddy, Kubo Hajime, Joladarashi Darukeshwara, Abraham Elizabeth, Mallaredy Vandana, Cheng Zhongjian, Mcmullan Elena, Wittmann Christopher, Thakur Abhimanyu, Cimini Maria, Truongcao May, Natarajaseenivasan Suriya Muthukumaran, Benedict Cindy, Ghosh Jayashri, Garikipati Venkata, Estaras Conchi, Kishore Raj
Keywords: Epigenetics , Remodeling , Myocardial infarction
02 : 30 PM
Early Systemic Immune Response After Cardiac Arrest and The Immunomodulatory and Neuroprotective Effects of LPC(22:6)
Espin Blanca, Kazmi Jacob, Tahavvori Amir, Singh Parmeshar, Sharma Arjun, Becker Lance, Kim Junhwan
Final Pr. ID: LBP25
Authors: Espin Blanca, Kazmi Jacob, Tahavvori Amir, Singh Parmeshar, Sharma Arjun, Becker Lance, Kim Junhwan
Keywords: Immunologic techniques , Cardiac arrest
02 : 30 PM
Exosome-loaded with Small Cajal Body Associated RNA20: A Novel Therapeutic Strategy for Cardiovascular Disease
Rajasingh Sheeja, Vembuli Hemanathan, Johnson Rajasingh
Final Pr. ID: LBP6
Authors: Rajasingh Sheeja, Vembuli Hemanathan, Johnson Rajasingh
Keywords: Tissue engineering , Stem cell therapy , Stem cells , Cardiovascular therapeutics , Cardiac regeneration