American Heart Association
Novel Therapies and Molecular Targets in Heart Failure with Preserved Ejection Fraction
Moderated Digital Poster Session
Clinical Science Zone 2, Moderated Digital Poster 19
Nov 9th , 03:15 PM - 04:30 PM
03 : 15 PM
FB-1083 demonstrates potent efficacy in preclinical models of Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension
Deforest Natalie, Jones Rob, Haptonstall Kacey, Hermans Ashley, Zehnder Ashley, Burkey Bryan, Goodman Linda, Grabek Katharine, Sprenger Ryan, Song Rui, Tran Evelyn, Mcnamara Phil, Gorin Gennady, Henig Noreen
Final Pr. ID: MP1670
Authors: Deforest Natalie, Jones Rob, Haptonstall Kacey, Hermans Ashley, Zehnder Ashley, Burkey Bryan, Goodman Linda, Grabek Katharine, Sprenger Ryan, Song Rui, Tran Evelyn, Mcnamara Phil, Gorin Gennady, Henig Noreen
Keywords: Heart failure , Cardiovascular therapeutics , Cardiac metabolism
03 : 22 PM
A RETRO-ENANTIOMER OF ANGIOTENSIN-(1-9) PREVENTS THE DEVELOPMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Ocaranza Maria Paz, Jimenez Veronica, Yanez Osvaldo, Jalil Jorge, Venegas Camilo, Candia Camila, Hermoso Marcela, Gabrielli Luigi, Morales Javier, Oyarzun Felipe, Torres Cristian, Lillo Pablo
Final Pr. ID: MP1671
Authors: Ocaranza Maria Paz, Jimenez Veronica, Yanez Osvaldo, Jalil Jorge, Venegas Camilo, Candia Camila, Hermoso Marcela, Gabrielli Luigi, Morales Javier, Oyarzun Felipe, Torres Cristian, Lillo Pablo
Keywords: Cardiovascular disease prevention , Cardioprotection , HFpEF , Renin-Aldosterone-Angiotensin (Raa)
03 : 29 PM
VS-041, a narrow-spectrum, matrix metalloproteinase (MMP) inhibitor and novel drug candidate for heart failure with preserved ejection fraction (HFpEF), demonstrates target engagement and is safe and well-tolerated in healthy participants.
Henig Noreen, Bochenek Wieslaw, Krupa Magdalena, Berger Joel, Pratt Benjamin, Vekich John, Larson Christopher, Plonowski Artur
Final Pr. ID: MP1672
Authors: Henig Noreen, Bochenek Wieslaw, Krupa Magdalena, Berger Joel, Pratt Benjamin, Vekich John, Larson Christopher, Plonowski Artur
Keywords: HFpEF , Clinical trials , Pharmacokinetics , Safety , Fibrosis
03 : 36 PM
Impact of REGN5381, a Monoclonal Antibody Agonist to Natriuretic Peptide Receptor 1, on Pulmonary Capillary Wedge Pressure in Patients With Heart Failure With Preserved Ejection Fraction
Young Bryan, Hirshberg Boaz, George Richard, Olenchock Benjamin, Devalaraja-narashimha Kishor, Morton Lori, Janssens Stefan, Redaelli Giulia, Mei Jingning, Kithcart Aaron, Herman Gary
Final Pr. ID: MP1673
Authors: Young Bryan, Hirshberg Boaz, George Richard, Olenchock Benjamin, Devalaraja-narashimha Kishor, Morton Lori, Janssens Stefan, Redaelli Giulia, Mei Jingning, Kithcart Aaron, Herman Gary
Keywords: Heart failure , Blood pressure , Ejection fraction , Natriuretic peptide , HFpEF
03 : 43 PM
Titin hyperphosphorylation of skeletal muscle from heart failure with preserved ejection fraction patients is correlated with their peakVO2
Vahle Beatrice, Winzer Ephraim, Halle Martin, Van Craenenbroeck Emeline, Wisloff Ulrik, Linke Axel, Gielen Stephan, Adams Volker
Final Pr. ID: MP1674
Authors: Vahle Beatrice, Winzer Ephraim, Halle Martin, Van Craenenbroeck Emeline, Wisloff Ulrik, Linke Axel, Gielen Stephan, Adams Volker
Keywords: Muscle , skeletal , Titin , HFpEF , Muscle biopsy
03 : 50 PM
Endogenous C-type natriuretic peptide maintains cardiac structure and function in heart failure with preserved ejection fraction
Dickinson Yasmin, Aubdool Aisah, Vicencio Jose, Villar Conchi, Moyes Amie, Hobbs Adrian
Final Pr. ID: MP1675
Authors: Dickinson Yasmin, Aubdool Aisah, Vicencio Jose, Villar Conchi, Moyes Amie, Hobbs Adrian
Keywords: Natriuretic peptide , Heart failure , Fibrosis , Diastolic function , Inflammation
03 : 57 PM
Protein Tyrosine Phosphatase 1B Inhibition Rescues From Metabolic Dysfunction-Induced Cardiomyopathy And HFpEF
Mishra Abhishek, Kessinger Chase, Hodgson Myles, Tonks Nicholas, Kontaridis Maria
Final Pr. ID: MP1676
Authors: Mishra Abhishek, Kessinger Chase, Hodgson Myles, Tonks Nicholas, Kontaridis Maria
Keywords: Heart failure , Cardiomyopathy , Obesity , HFpEF , Phosphatases
04 : 04 PM
Proteomic and Phosphoproteomic Profiling of Cardiac Left Ventricular Tissue from an Animal Model of Early Stage Heart Failure with Preserved Ejection Fraction after Soluble Guanylate Cyclase Stimulation
Vázquez-abuín Xocas, Goncalves Alexandre, Pereira Morais Juliana, Alves Ines N, Sousa-mendes Claudia, Pires Inês, GonzÁlez-juanatey Jose RamÓn, Feijoo-bandin Sandra, Lago Maria Francisca, Morana-fernandez Sandra, Aragon-herrera Alana, Sandner Peter, Thomitzek Karen, Garcia-seara Francisco Javier, Bravo Susana B, Otero-santiago Manuel Francisco, Rodrigues Alexandre
Final Pr. ID: MP1677
Authors: Vázquez-abuín Xocas, Goncalves Alexandre, Pereira Morais Juliana, Alves Ines N, Sousa-mendes Claudia, Pires Inês, GonzÁlez-juanatey Jose RamÓn, Feijoo-bandin Sandra, Lago Maria Francisca, Morana-fernandez Sandra, Aragon-herrera Alana, Sandner Peter, Thomitzek Karen, Garcia-seara Francisco Javier, Bravo Susana B, Otero-santiago Manuel Francisco, Rodrigues Alexandre
Keywords: Heart failure , Proteomics , Proteome , Phosphorylation , Mitochondria
04 : 11 PM
Extracellular Volume and T1 Mapping by Cardiac MRI Predict Outcomes in HFpEF: A Systematic Review and Meta-Analysis
Behnoush Amir Hossein, Lee Daniel
Final Pr. ID: MP1678
Authors: Behnoush Amir Hossein, Lee Daniel
Keywords: HFpEF , Magnetic resonance , Prognosis , Fibrosis
04 : 18 PM
The Role of Myocardial Histological Remodeling in Exercise Intolerance Among Patients with Heart Failure with Preserved Ejection Fraction
Tanacli Radu, Tajdini Masih, Jani Vivek, Dai Dao-fu, Sharma Kavita
Final Pr. ID: MP1679
Authors: Tanacli Radu, Tajdini Masih, Jani Vivek, Dai Dao-fu, Sharma Kavita
Keywords: HFpEF , Myocardium , Hypertrophy , Fibrosis , Hemodynamics
03 : 22 PM
A RETRO-ENANTIOMER OF ANGIOTENSIN-(1-9) PREVENTS THE DEVELOPMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Ocaranza Maria Paz, Jimenez Veronica, Yanez Osvaldo, Jalil Jorge, Venegas Camilo, Candia Camila, Hermoso Marcela, Gabrielli Luigi, Morales Javier, Oyarzun Felipe, Torres Cristian, Lillo Pablo
Final Pr. ID: MP1671
Authors: Ocaranza Maria Paz, Jimenez Veronica, Yanez Osvaldo, Jalil Jorge, Venegas Camilo, Candia Camila, Hermoso Marcela, Gabrielli Luigi, Morales Javier, Oyarzun Felipe, Torres Cristian, Lillo Pablo
Keywords: Cardiovascular disease prevention , Cardioprotection , HFpEF , Renin-Aldosterone-Angiotensin (Raa)
03 : 50 PM
Endogenous C-type natriuretic peptide maintains cardiac structure and function in heart failure with preserved ejection fraction
Dickinson Yasmin, Aubdool Aisah, Vicencio Jose, Villar Conchi, Moyes Amie, Hobbs Adrian
Final Pr. ID: MP1675
Authors: Dickinson Yasmin, Aubdool Aisah, Vicencio Jose, Villar Conchi, Moyes Amie, Hobbs Adrian
Keywords: Natriuretic peptide , Heart failure , Fibrosis , Diastolic function , Inflammation
04 : 11 PM
Extracellular Volume and T1 Mapping by Cardiac MRI Predict Outcomes in HFpEF: A Systematic Review and Meta-Analysis
Behnoush Amir Hossein, Lee Daniel
Final Pr. ID: MP1678
Authors: Behnoush Amir Hossein, Lee Daniel
Keywords: HFpEF , Magnetic resonance , Prognosis , Fibrosis
03 : 15 PM
FB-1083 demonstrates potent efficacy in preclinical models of Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension
Deforest Natalie, Jones Rob, Haptonstall Kacey, Hermans Ashley, Zehnder Ashley, Burkey Bryan, Goodman Linda, Grabek Katharine, Sprenger Ryan, Song Rui, Tran Evelyn, Mcnamara Phil, Gorin Gennady, Henig Noreen
Final Pr. ID: MP1670
Authors: Deforest Natalie, Jones Rob, Haptonstall Kacey, Hermans Ashley, Zehnder Ashley, Burkey Bryan, Goodman Linda, Grabek Katharine, Sprenger Ryan, Song Rui, Tran Evelyn, Mcnamara Phil, Gorin Gennady, Henig Noreen
Keywords: Heart failure , Cardiovascular therapeutics , Cardiac metabolism
03 : 36 PM
Impact of REGN5381, a Monoclonal Antibody Agonist to Natriuretic Peptide Receptor 1, on Pulmonary Capillary Wedge Pressure in Patients With Heart Failure With Preserved Ejection Fraction
Young Bryan, Hirshberg Boaz, George Richard, Olenchock Benjamin, Devalaraja-narashimha Kishor, Morton Lori, Janssens Stefan, Redaelli Giulia, Mei Jingning, Kithcart Aaron, Herman Gary
Final Pr. ID: MP1673
Authors: Young Bryan, Hirshberg Boaz, George Richard, Olenchock Benjamin, Devalaraja-narashimha Kishor, Morton Lori, Janssens Stefan, Redaelli Giulia, Mei Jingning, Kithcart Aaron, Herman Gary
Keywords: Heart failure , Blood pressure , Ejection fraction , Natriuretic peptide , HFpEF
03 : 57 PM
Protein Tyrosine Phosphatase 1B Inhibition Rescues From Metabolic Dysfunction-Induced Cardiomyopathy And HFpEF
Mishra Abhishek, Kessinger Chase, Hodgson Myles, Tonks Nicholas, Kontaridis Maria
Final Pr. ID: MP1676
Authors: Mishra Abhishek, Kessinger Chase, Hodgson Myles, Tonks Nicholas, Kontaridis Maria
Keywords: Heart failure , Cardiomyopathy , Obesity , HFpEF , Phosphatases
04 : 04 PM
Proteomic and Phosphoproteomic Profiling of Cardiac Left Ventricular Tissue from an Animal Model of Early Stage Heart Failure with Preserved Ejection Fraction after Soluble Guanylate Cyclase Stimulation
Vázquez-abuín Xocas, Goncalves Alexandre, Pereira Morais Juliana, Alves Ines N, Sousa-mendes Claudia, Pires Inês, GonzÁlez-juanatey Jose RamÓn, Feijoo-bandin Sandra, Lago Maria Francisca, Morana-fernandez Sandra, Aragon-herrera Alana, Sandner Peter, Thomitzek Karen, Garcia-seara Francisco Javier, Bravo Susana B, Otero-santiago Manuel Francisco, Rodrigues Alexandre
Final Pr. ID: MP1677
Authors: Vázquez-abuín Xocas, Goncalves Alexandre, Pereira Morais Juliana, Alves Ines N, Sousa-mendes Claudia, Pires Inês, GonzÁlez-juanatey Jose RamÓn, Feijoo-bandin Sandra, Lago Maria Francisca, Morana-fernandez Sandra, Aragon-herrera Alana, Sandner Peter, Thomitzek Karen, Garcia-seara Francisco Javier, Bravo Susana B, Otero-santiago Manuel Francisco, Rodrigues Alexandre
Keywords: Heart failure , Proteomics , Proteome , Phosphorylation , Mitochondria
04 : 18 PM
The Role of Myocardial Histological Remodeling in Exercise Intolerance Among Patients with Heart Failure with Preserved Ejection Fraction
Tanacli Radu, Tajdini Masih, Jani Vivek, Dai Dao-fu, Sharma Kavita
Final Pr. ID: MP1679
Authors: Tanacli Radu, Tajdini Masih, Jani Vivek, Dai Dao-fu, Sharma Kavita
Keywords: HFpEF , Myocardium , Hypertrophy , Fibrosis , Hemodynamics
03 : 43 PM
Titin hyperphosphorylation of skeletal muscle from heart failure with preserved ejection fraction patients is correlated with their peakVO2
Vahle Beatrice, Winzer Ephraim, Halle Martin, Van Craenenbroeck Emeline, Wisloff Ulrik, Linke Axel, Gielen Stephan, Adams Volker
Final Pr. ID: MP1674
Authors: Vahle Beatrice, Winzer Ephraim, Halle Martin, Van Craenenbroeck Emeline, Wisloff Ulrik, Linke Axel, Gielen Stephan, Adams Volker
Keywords: Muscle , skeletal , Titin , HFpEF , Muscle biopsy
03 : 29 PM
VS-041, a narrow-spectrum, matrix metalloproteinase (MMP) inhibitor and novel drug candidate for heart failure with preserved ejection fraction (HFpEF), demonstrates target engagement and is safe and well-tolerated in healthy participants.
Henig Noreen, Bochenek Wieslaw, Krupa Magdalena, Berger Joel, Pratt Benjamin, Vekich John, Larson Christopher, Plonowski Artur
Final Pr. ID: MP1672
Authors: Henig Noreen, Bochenek Wieslaw, Krupa Magdalena, Berger Joel, Pratt Benjamin, Vekich John, Larson Christopher, Plonowski Artur
Keywords: HFpEF , Clinical trials , Pharmacokinetics , Safety , Fibrosis