American Heart Association
Mechanistic Advances in Heart Disease: Targeting Remodeling, Aging, and Inflammation
Moderated Digital Poster Session
Basic Science Zone, Moderated Digital Poster 25
Nov 9th , 09:15 AM - 10:25 AM
09 : 15 AM
Inhibition of PDE10A Attenuates Pressure Overload-induced Right Ventricular Dysfunction via Modulation of Calcium Signaling and β-Catenin Pathways
Nakashima Shunsuke, Ikeda Masataka, Shinohara Keisuke, Katsuki Shunsuke, Matoba Tetsuya, Matsushima Shouji, Kinugawa Shintaro, Abe Kohtaro, Hashimoto Toru, Kai Takashi, Yamamoto Yuta, Noda Eri, Ikeda Yuki, Suenaga Tomoyasu, Toyohara Takayuki, Yoshida Keimei
Final Pr. ID: MP1824
Authors: Nakashima Shunsuke, Ikeda Masataka, Shinohara Keisuke, Katsuki Shunsuke, Matoba Tetsuya, Matsushima Shouji, Kinugawa Shintaro, Abe Kohtaro, Hashimoto Toru, Kai Takashi, Yamamoto Yuta, Noda Eri, Ikeda Yuki, Suenaga Tomoyasu, Toyohara Takayuki, Yoshida Keimei
Keywords: Right Ventricular Dysfunction , Heart failure , Calcium , Cardiac hypertrophy , Ventricular remodeling
09 : 22 AM
Divergent Remodeling from Adjacent TNNC1 N-terminal Variants: Mechanistic Insight into Sarcomere Dysfunction in Inherited Cardiomyopathies
Nieto Morales Paula, Chase P, Pinto Jose Renato, Holdrum Nichika, Reilly Andrew, Wirstiuk Lillian, He Huan, Dieseldorff Jones Karissa, Landim-vieira Maicon, Kanashiro-takeuchi Rosemeire, Chelko Stephen
Final Pr. ID: MP1825
Authors: Nieto Morales Paula, Chase P, Pinto Jose Renato, Holdrum Nichika, Reilly Andrew, Wirstiuk Lillian, He Huan, Dieseldorff Jones Karissa, Landim-vieira Maicon, Kanashiro-takeuchi Rosemeire, Chelko Stephen
Keywords: Cardiomyopathy , Calcium , Cell physiology
09 : 29 AM
Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9)-Mediated Platelet Activation Elicits NETs Formation via Cathepsin-G
Cammisotto Vittoria, Scicali Roberto, Russo Isabella, Purrello Francesco, Arca Marcello, Pastori Daniele, Carnevale Roberto, Violi Francesco, Pignatelli Pasquale, Valeriani Emanuele, Castellani Valentina, Baratta Francesco, Cocomello Nicholas, Bartimoccia Simona, Nocella Cristina, D'erasmo Laura, Barale Cristina
Final Pr. ID: MP1826
Authors: Cammisotto Vittoria, Scicali Roberto, Russo Isabella, Purrello Francesco, Arca Marcello, Pastori Daniele, Carnevale Roberto, Violi Francesco, Pignatelli Pasquale, Valeriani Emanuele, Castellani Valentina, Baratta Francesco, Cocomello Nicholas, Bartimoccia Simona, Nocella Cristina, D'erasmo Laura, Barale Cristina
Keywords: Thrombosis , Cardiovascular disease , Hypercholesterolemia
09 : 36 AM
The Novel Muscle-specific RING Finger-2 Target Sorting Nexin 5 Regulates Protein kinase A Activity through Stabilization of Protein Kinase A Regulatory Subunit Type Iα and Controls Myogenic Differentiation
Li Ning, Li Yi, Brinschwitz Bjoern, Ghait Mohamed, Hammer Elke, Fielitz Jens
Final Pr. ID: MP1827
Authors: Li Ning, Li Yi, Brinschwitz Bjoern, Ghait Mohamed, Hammer Elke, Fielitz Jens
Keywords: Cell signaling , Muscle , skeletal , Molecular biology , Proteasome , Ubiquitin
09 : 43 AM
S100A9 Induces BRD4 (K292) Lactylation in Macrophages to Exacerbate Inflammaging in Diabetic Cardiomyopathy
Huo Shengqi, Ren Bowen
Final Pr. ID: MP1828
Authors: Huo Shengqi, Ren Bowen
Keywords: Aging , Epigenetics , Heart failure , Diabetes Mellitus , Inflammation and inflammatory markers
09 : 50 AM
R-propranolol Attenuates Interleukin-18 Mediated Sickle Cell Cardiomyopathy: A Novel Adrenergic-independent Mechanism Involving Lipid Synthesis.
Jia Yangfan, Bronk Peter, Chu Aiai, Kim Tae Yun, Lu Yichun, Javaheri Ali, Tang Haiyang, Choi Bum-rak, Desai Ankit
Final Pr. ID: MP1829
Authors: Jia Yangfan, Bronk Peter, Chu Aiai, Kim Tae Yun, Lu Yichun, Javaheri Ali, Tang Haiyang, Choi Bum-rak, Desai Ankit
Keywords: Sickle cell disease , Cardiomyopathy , Endothelial , Inflammation and inflammatory markers , Ventricular arrhythmia
09 : 57 AM
Placental-derived Senescence Associated Secretory Proteins Increase Atrial Fibrillation Susceptibility in Pregnancy
Castro Claire, Xiao Chunyang, Gray Kathryn, Edlow Andrea, Ellinor Patrick, Roh Jason
Final Pr. ID: MP1831
Authors: Castro Claire, Xiao Chunyang, Gray Kathryn, Edlow Andrea, Ellinor Patrick, Roh Jason
Keywords: Atrial fibrillation , Pregnancy , Women’s Health , Adverse Pregnancy Outcomes , Aging
10 : 04 AM
CHK1 Activates Mitophagy to Attenuate Cardiac Senescence via Inhibiting AHSA1-Ubiquitination
Jing Peng, Wang Hao, Yang Tongtong, Zhou Liu-hua, Wang Liansheng
Final Pr. ID: MP1832
Authors: Jing Peng, Wang Hao, Yang Tongtong, Zhou Liu-hua, Wang Liansheng
Keywords: Aging , Mitochondria , Autophagy , Cardiovascular disease prevention
10 : 11 AM
4D Cardiac Optogenetics Enable Complex Arrhythmia Modelling and Precise Interventional Simulation
Wexler Yehuda, Grinstein Harel, Landesberg Michal, Glatstein Shany, Huber Irit, Arbel Gil, Gepstein Lior
Final Pr. ID: MP1833
Authors: Wexler Yehuda, Grinstein Harel, Landesberg Michal, Glatstein Shany, Huber Irit, Arbel Gil, Gepstein Lior
Keywords: Stem cells , Arrhythmias , Ablation , Electrophysiology , Cardiac mapping
10 : 11 AM
4D Cardiac Optogenetics Enable Complex Arrhythmia Modelling and Precise Interventional Simulation
Wexler Yehuda, Grinstein Harel, Landesberg Michal, Glatstein Shany, Huber Irit, Arbel Gil, Gepstein Lior
Final Pr. ID: MP1833
Authors: Wexler Yehuda, Grinstein Harel, Landesberg Michal, Glatstein Shany, Huber Irit, Arbel Gil, Gepstein Lior
Keywords: Stem cells , Arrhythmias , Ablation , Electrophysiology , Cardiac mapping
10 : 04 AM
CHK1 Activates Mitophagy to Attenuate Cardiac Senescence via Inhibiting AHSA1-Ubiquitination
Jing Peng, Wang Hao, Yang Tongtong, Zhou Liu-hua, Wang Liansheng
Final Pr. ID: MP1832
Authors: Jing Peng, Wang Hao, Yang Tongtong, Zhou Liu-hua, Wang Liansheng
Keywords: Aging , Mitochondria , Autophagy , Cardiovascular disease prevention
09 : 22 AM
Divergent Remodeling from Adjacent TNNC1 N-terminal Variants: Mechanistic Insight into Sarcomere Dysfunction in Inherited Cardiomyopathies
Nieto Morales Paula, Chase P, Pinto Jose Renato, Holdrum Nichika, Reilly Andrew, Wirstiuk Lillian, He Huan, Dieseldorff Jones Karissa, Landim-vieira Maicon, Kanashiro-takeuchi Rosemeire, Chelko Stephen
Final Pr. ID: MP1825
Authors: Nieto Morales Paula, Chase P, Pinto Jose Renato, Holdrum Nichika, Reilly Andrew, Wirstiuk Lillian, He Huan, Dieseldorff Jones Karissa, Landim-vieira Maicon, Kanashiro-takeuchi Rosemeire, Chelko Stephen
Keywords: Cardiomyopathy , Calcium , Cell physiology
09 : 15 AM
Inhibition of PDE10A Attenuates Pressure Overload-induced Right Ventricular Dysfunction via Modulation of Calcium Signaling and β-Catenin Pathways
Nakashima Shunsuke, Ikeda Masataka, Shinohara Keisuke, Katsuki Shunsuke, Matoba Tetsuya, Matsushima Shouji, Kinugawa Shintaro, Abe Kohtaro, Hashimoto Toru, Kai Takashi, Yamamoto Yuta, Noda Eri, Ikeda Yuki, Suenaga Tomoyasu, Toyohara Takayuki, Yoshida Keimei
Final Pr. ID: MP1824
Authors: Nakashima Shunsuke, Ikeda Masataka, Shinohara Keisuke, Katsuki Shunsuke, Matoba Tetsuya, Matsushima Shouji, Kinugawa Shintaro, Abe Kohtaro, Hashimoto Toru, Kai Takashi, Yamamoto Yuta, Noda Eri, Ikeda Yuki, Suenaga Tomoyasu, Toyohara Takayuki, Yoshida Keimei
Keywords: Right Ventricular Dysfunction , Heart failure , Calcium , Cardiac hypertrophy , Ventricular remodeling
09 : 57 AM
Placental-derived Senescence Associated Secretory Proteins Increase Atrial Fibrillation Susceptibility in Pregnancy
Castro Claire, Xiao Chunyang, Gray Kathryn, Edlow Andrea, Ellinor Patrick, Roh Jason
Final Pr. ID: MP1831
Authors: Castro Claire, Xiao Chunyang, Gray Kathryn, Edlow Andrea, Ellinor Patrick, Roh Jason
Keywords: Atrial fibrillation , Pregnancy , Women’s Health , Adverse Pregnancy Outcomes , Aging
09 : 29 AM
Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9)-Mediated Platelet Activation Elicits NETs Formation via Cathepsin-G
Cammisotto Vittoria, Scicali Roberto, Russo Isabella, Purrello Francesco, Arca Marcello, Pastori Daniele, Carnevale Roberto, Violi Francesco, Pignatelli Pasquale, Valeriani Emanuele, Castellani Valentina, Baratta Francesco, Cocomello Nicholas, Bartimoccia Simona, Nocella Cristina, D'erasmo Laura, Barale Cristina
Final Pr. ID: MP1826
Authors: Cammisotto Vittoria, Scicali Roberto, Russo Isabella, Purrello Francesco, Arca Marcello, Pastori Daniele, Carnevale Roberto, Violi Francesco, Pignatelli Pasquale, Valeriani Emanuele, Castellani Valentina, Baratta Francesco, Cocomello Nicholas, Bartimoccia Simona, Nocella Cristina, D'erasmo Laura, Barale Cristina
Keywords: Thrombosis , Cardiovascular disease , Hypercholesterolemia
09 : 50 AM
R-propranolol Attenuates Interleukin-18 Mediated Sickle Cell Cardiomyopathy: A Novel Adrenergic-independent Mechanism Involving Lipid Synthesis.
Jia Yangfan, Bronk Peter, Chu Aiai, Kim Tae Yun, Lu Yichun, Javaheri Ali, Tang Haiyang, Choi Bum-rak, Desai Ankit
Final Pr. ID: MP1829
Authors: Jia Yangfan, Bronk Peter, Chu Aiai, Kim Tae Yun, Lu Yichun, Javaheri Ali, Tang Haiyang, Choi Bum-rak, Desai Ankit
Keywords: Sickle cell disease , Cardiomyopathy , Endothelial , Inflammation and inflammatory markers , Ventricular arrhythmia
09 : 43 AM
S100A9 Induces BRD4 (K292) Lactylation in Macrophages to Exacerbate Inflammaging in Diabetic Cardiomyopathy
Huo Shengqi, Ren Bowen
Final Pr. ID: MP1828
Authors: Huo Shengqi, Ren Bowen
Keywords: Aging , Epigenetics , Heart failure , Diabetes Mellitus , Inflammation and inflammatory markers
09 : 36 AM
The Novel Muscle-specific RING Finger-2 Target Sorting Nexin 5 Regulates Protein kinase A Activity through Stabilization of Protein Kinase A Regulatory Subunit Type Iα and Controls Myogenic Differentiation
Li Ning, Li Yi, Brinschwitz Bjoern, Ghait Mohamed, Hammer Elke, Fielitz Jens
Final Pr. ID: MP1827
Authors: Li Ning, Li Yi, Brinschwitz Bjoern, Ghait Mohamed, Hammer Elke, Fielitz Jens
Keywords: Cell signaling , Muscle , skeletal , Molecular biology , Proteasome , Ubiquitin