American Heart Association
Exploring New Horizons: New Therapeutic Targets in Pulmonary Hypertension
Moderated Digital Poster Session
Clinical Science Zone 2, Moderated Digital Poster 22
Nov 9th , 09:15 AM - 10:30 AM
09 : 15 AM
HS235, a Novel Activin Signaling Inhibitor, is Highly Efficacious in Preclinical Models of Pulmonary Hypertension and Heart Failure
Schang Gauthier, Brûlé Emilie, Dilasser Florian, Nandi Ipshita, Denis Jean-francois, Sours Ariane, Ganesh Vann, Samadfam Rana, Tremblay Gilles, Schoelermann Julia, O'connor-mccourt Maureen
Final Pr. ID: MP1738
Authors: Schang Gauthier, Brûlé Emilie, Dilasser Florian, Nandi Ipshita, Denis Jean-francois, Sours Ariane, Ganesh Vann, Samadfam Rana, Tremblay Gilles, Schoelermann Julia, O'connor-mccourt Maureen
Keywords: Cardiometabolic health , Pulmonary hypertension , Heart failure
09 : 22 AM
Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates pulmonary hypertension
Inagaki Tadakatsu, Yamagishi Akiko, Okazawa Makoto, Ding Xin, Umeki-mizushima Saori, Asano Ryotaro, Tse Ka Man, Akaki Kotaro, Takeuti Osamu, Nakaoka Yoshikazu
Final Pr. ID: MP1739
Authors: Inagaki Tadakatsu, Yamagishi Akiko, Okazawa Makoto, Ding Xin, Umeki-mizushima Saori, Asano Ryotaro, Tse Ka Man, Akaki Kotaro, Takeuti Osamu, Nakaoka Yoshikazu
Keywords: Pulmonary hypertension , Inflammation
09 : 29 AM
Biased small molecule RXFP1 agonists ameliorate experimental pulmonary hypertension and RV hypertrophy
Rajesh Shreyas, Sangam Shreya, Triantafyllou Georgios, Pham Uyen, Troncone Luca, Gipson Gregory, Henderson Mark, Marugan Juan, Agoulnik Irina, Agoulnik Alexander, Rajagopal Sudarshan, Yu Paul
Final Pr. ID: MP1740
Authors: Rajesh Shreyas, Sangam Shreya, Triantafyllou Georgios, Pham Uyen, Troncone Luca, Gipson Gregory, Henderson Mark, Marugan Juan, Agoulnik Irina, Agoulnik Alexander, Rajagopal Sudarshan, Yu Paul
Keywords: Pulmonary hypertension , Smooth muscle , Right Ventricular
09 : 43 AM
NEDD9 Inhibition Reverses Fibrotic Remodeling In Experimental Pulmonary Arterial Hypertension
Samokhin Andriy, Daum Jacqueline, Saha Progyaparamita, Maron Bradley
Final Pr. ID: MP1742
Authors: Samokhin Andriy, Daum Jacqueline, Saha Progyaparamita, Maron Bradley
Keywords: Pulmonary hypertension , Endothelial function , Extracellular matrix , Fibrosis , Pulmonary artery
09 : 50 AM
Interleukin-6 Neutralization in Pulmonary Arterial Hypertension: Emerging Therapeutic Potential
Mansoori Maryam, Jankowski Katherine, Santos-gallego Carlos, Sassi Yassine, Hassoun Paul, Bisserier Malik, Hadri Lahouaria
Final Pr. ID: MP1743
Authors: Mansoori Maryam, Jankowski Katherine, Santos-gallego Carlos, Sassi Yassine, Hassoun Paul, Bisserier Malik, Hadri Lahouaria
Keywords: Pulmonary hypertension , Cardiovascular , Epigenetics , Gene therapy
09 : 57 AM
Platelet-derived growth factor antagonist antibody attenuates pulmonary arterial hypertension and prevents right heart dysfunction in the Sugen-Hypoxia rat model
Powers Kristi, Gao Yinglin, Preda Marilena, Sundaram Bharathi, Del Priore Isabella, Spencer Noakes Leigh, Quadri Nosirudeen, Walls Johnathon, Shekhar Akshay, Morton Lori
Final Pr. ID: MP1744
Authors: Powers Kristi, Gao Yinglin, Preda Marilena, Sundaram Bharathi, Del Priore Isabella, Spencer Noakes Leigh, Quadri Nosirudeen, Walls Johnathon, Shekhar Akshay, Morton Lori
Keywords: Pulmonary artery , Hypertension , Pulmonary hypertension , Monoclonal antibodies , Ventricular function
10 : 04 AM
Targeting SIN3a-Mediated FOXK2 Regulation to Restore BMPR2 Expression and Reverse Endothelial Dysfunction in Pulmonary Arterial Hypertension
Kaur Prabhjot, Natarajaseenivasan Suriya Muthukumaran, Perros Frederic, Bonnet Sebastien, Garikipati Venkata, Sassi Yassine, Bisserier Malik, Hadri Lahouaria
Final Pr. ID: MP1745
Authors: Kaur Prabhjot, Natarajaseenivasan Suriya Muthukumaran, Perros Frederic, Bonnet Sebastien, Garikipati Venkata, Sassi Yassine, Bisserier Malik, Hadri Lahouaria
Keywords: Pulmonary hypertension , Cardiovascular disease , Epigenetics , Gene therapy , Endothelial function
10 : 11 AM
Extracellular Vesicles Enhance Cardiovascular and Protein Adaptations in Mice With Pulmonary Hypertension
Fuguhara Vivian, Blume Corssac Giana, Brinck Teixeira Rayane, Karbasiafshar Catherine, Liang Olin, Sellke Frank, Bello-klein Adriane, Abid Ruhul
Final Pr. ID: MP1746
Authors: Fuguhara Vivian, Blume Corssac Giana, Brinck Teixeira Rayane, Karbasiafshar Catherine, Liang Olin, Sellke Frank, Bello-klein Adriane, Abid Ruhul
Keywords: Pulmonary hypertension , Proteomics
10 : 18 AM
The serum and glucocorticoid regulated kinase 1 (SGK1) inhibitor THRV-1268 attenuates hallmarks of heart failure by reducing inflammation and fibrosis beyond sodium/glucose cotransporter 2 inhibition
Campeau Eric, Pradhananga Sabindra, Srinivasan Dinesh, Labit Delphine, Frias Boligan Kayluz, Vidal Marc, Odink Debra, Truex Paul, Sehnert Amy, Das Saumya
Final Pr. ID: MP1747
Authors: Campeau Eric, Pradhananga Sabindra, Srinivasan Dinesh, Labit Delphine, Frias Boligan Kayluz, Vidal Marc, Odink Debra, Truex Paul, Sehnert Amy, Das Saumya
Keywords: Heart failure , Fibrosis , HFrEF , Inflammation and inflammatory markers , Biomarkers
09 : 29 AM
Biased small molecule RXFP1 agonists ameliorate experimental pulmonary hypertension and RV hypertrophy
Rajesh Shreyas, Sangam Shreya, Triantafyllou Georgios, Pham Uyen, Troncone Luca, Gipson Gregory, Henderson Mark, Marugan Juan, Agoulnik Irina, Agoulnik Alexander, Rajagopal Sudarshan, Yu Paul
Final Pr. ID: MP1740
Authors: Rajesh Shreyas, Sangam Shreya, Triantafyllou Georgios, Pham Uyen, Troncone Luca, Gipson Gregory, Henderson Mark, Marugan Juan, Agoulnik Irina, Agoulnik Alexander, Rajagopal Sudarshan, Yu Paul
Keywords: Pulmonary hypertension , Smooth muscle , Right Ventricular
09 : 22 AM
Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates pulmonary hypertension
Inagaki Tadakatsu, Yamagishi Akiko, Okazawa Makoto, Ding Xin, Umeki-mizushima Saori, Asano Ryotaro, Tse Ka Man, Akaki Kotaro, Takeuti Osamu, Nakaoka Yoshikazu
Final Pr. ID: MP1739
Authors: Inagaki Tadakatsu, Yamagishi Akiko, Okazawa Makoto, Ding Xin, Umeki-mizushima Saori, Asano Ryotaro, Tse Ka Man, Akaki Kotaro, Takeuti Osamu, Nakaoka Yoshikazu
Keywords: Pulmonary hypertension , Inflammation
10 : 11 AM
Extracellular Vesicles Enhance Cardiovascular and Protein Adaptations in Mice With Pulmonary Hypertension
Fuguhara Vivian, Blume Corssac Giana, Brinck Teixeira Rayane, Karbasiafshar Catherine, Liang Olin, Sellke Frank, Bello-klein Adriane, Abid Ruhul
Final Pr. ID: MP1746
Authors: Fuguhara Vivian, Blume Corssac Giana, Brinck Teixeira Rayane, Karbasiafshar Catherine, Liang Olin, Sellke Frank, Bello-klein Adriane, Abid Ruhul
Keywords: Pulmonary hypertension , Proteomics
09 : 15 AM
HS235, a Novel Activin Signaling Inhibitor, is Highly Efficacious in Preclinical Models of Pulmonary Hypertension and Heart Failure
Schang Gauthier, Brûlé Emilie, Dilasser Florian, Nandi Ipshita, Denis Jean-francois, Sours Ariane, Ganesh Vann, Samadfam Rana, Tremblay Gilles, Schoelermann Julia, O'connor-mccourt Maureen
Final Pr. ID: MP1738
Authors: Schang Gauthier, Brûlé Emilie, Dilasser Florian, Nandi Ipshita, Denis Jean-francois, Sours Ariane, Ganesh Vann, Samadfam Rana, Tremblay Gilles, Schoelermann Julia, O'connor-mccourt Maureen
Keywords: Cardiometabolic health , Pulmonary hypertension , Heart failure
09 : 50 AM
Interleukin-6 Neutralization in Pulmonary Arterial Hypertension: Emerging Therapeutic Potential
Mansoori Maryam, Jankowski Katherine, Santos-gallego Carlos, Sassi Yassine, Hassoun Paul, Bisserier Malik, Hadri Lahouaria
Final Pr. ID: MP1743
Authors: Mansoori Maryam, Jankowski Katherine, Santos-gallego Carlos, Sassi Yassine, Hassoun Paul, Bisserier Malik, Hadri Lahouaria
Keywords: Pulmonary hypertension , Cardiovascular , Epigenetics , Gene therapy
09 : 43 AM
NEDD9 Inhibition Reverses Fibrotic Remodeling In Experimental Pulmonary Arterial Hypertension
Samokhin Andriy, Daum Jacqueline, Saha Progyaparamita, Maron Bradley
Final Pr. ID: MP1742
Authors: Samokhin Andriy, Daum Jacqueline, Saha Progyaparamita, Maron Bradley
Keywords: Pulmonary hypertension , Endothelial function , Extracellular matrix , Fibrosis , Pulmonary artery
09 : 57 AM
Platelet-derived growth factor antagonist antibody attenuates pulmonary arterial hypertension and prevents right heart dysfunction in the Sugen-Hypoxia rat model
Powers Kristi, Gao Yinglin, Preda Marilena, Sundaram Bharathi, Del Priore Isabella, Spencer Noakes Leigh, Quadri Nosirudeen, Walls Johnathon, Shekhar Akshay, Morton Lori
Final Pr. ID: MP1744
Authors: Powers Kristi, Gao Yinglin, Preda Marilena, Sundaram Bharathi, Del Priore Isabella, Spencer Noakes Leigh, Quadri Nosirudeen, Walls Johnathon, Shekhar Akshay, Morton Lori
Keywords: Pulmonary artery , Hypertension , Pulmonary hypertension , Monoclonal antibodies , Ventricular function
10 : 04 AM
Targeting SIN3a-Mediated FOXK2 Regulation to Restore BMPR2 Expression and Reverse Endothelial Dysfunction in Pulmonary Arterial Hypertension
Kaur Prabhjot, Natarajaseenivasan Suriya Muthukumaran, Perros Frederic, Bonnet Sebastien, Garikipati Venkata, Sassi Yassine, Bisserier Malik, Hadri Lahouaria
Final Pr. ID: MP1745
Authors: Kaur Prabhjot, Natarajaseenivasan Suriya Muthukumaran, Perros Frederic, Bonnet Sebastien, Garikipati Venkata, Sassi Yassine, Bisserier Malik, Hadri Lahouaria
Keywords: Pulmonary hypertension , Cardiovascular disease , Epigenetics , Gene therapy , Endothelial function
10 : 18 AM
The serum and glucocorticoid regulated kinase 1 (SGK1) inhibitor THRV-1268 attenuates hallmarks of heart failure by reducing inflammation and fibrosis beyond sodium/glucose cotransporter 2 inhibition
Campeau Eric, Pradhananga Sabindra, Srinivasan Dinesh, Labit Delphine, Frias Boligan Kayluz, Vidal Marc, Odink Debra, Truex Paul, Sehnert Amy, Das Saumya
Final Pr. ID: MP1747
Authors: Campeau Eric, Pradhananga Sabindra, Srinivasan Dinesh, Labit Delphine, Frias Boligan Kayluz, Vidal Marc, Odink Debra, Truex Paul, Sehnert Amy, Das Saumya
Keywords: Heart failure , Fibrosis , HFrEF , Inflammation and inflammatory markers , Biomarkers