Showing 9 Abstracts.
12 : 39 PM
A First-In-Human Phase 1 Study of the Safety, Tolerability, and Pharmacodynamics of REGN7544, a Novel Natriuretic Peptide Receptor 1–Blocking Monoclonal Antibody
Ahmed Mohsin, Tuckwell Katie, Xu Meng, Cheng Xiping, Redington Emily, Koyani Bharatkumar, Mateo Katrina, Thakur Mazhar, Devalaraja-narashimha Kishor, Morton Lori, Olenchock Benjamin, Herman Gary, Wynne Chris, Marin Ethan
Final Pr. ID: MP1725
Authors: Ahmed Mohsin, Tuckwell Katie, Xu Meng, Cheng Xiping, Redington Emily, Koyani Bharatkumar, Mateo Katrina, Thakur Mazhar, Devalaraja-narashimha Kishor, Morton Lori, Olenchock Benjamin, Herman Gary, Wynne Chris, Marin Ethan
Keywords: Natriuretic peptide, Monoclonal antibodies, Clinical trials, Blood pressure
03 : 15 PM
ANGPTL3 Targeting Monoclonal Antibodies Lead to Robust Reductions in LDL-C, Triglycerides, ApoB, and Non-HDL-C in Dyslipidemic Patients: A Meta-Analysis of 5 Randomized Controlled Trials
Daid Simranpreet Singh, Sharma Anubhuti, Sharma Arundhati, Pannu Sagal, Asnani Heena, Bhanushali Karan, Choudhary Khushal, Sharma Saurabh
Final Pr. ID: Su2130
Authors: Daid Simranpreet Singh, Sharma Anubhuti, Sharma Arundhati, Pannu Sagal, Asnani Heena, Bhanushali Karan, Choudhary Khushal, Sharma Saurabh
Keywords: LDL, Cholesterol-lowering drugs, Dyslipidemia, Monoclonal antibodies, Hypercholesterolemia
12 : 39 PM
CAR-T Therapies Associated with Higher CRS-Linked Cardiotoxicity Signal than BiTE Agents in Multiple Myeloma: Analysis of Adverse Event Report
Tangella Adarshvardhan, Ayyalu Tanesh, Spahr Zachary, Taylor Allen
Final Pr. ID: MP1667
Authors: Tangella Adarshvardhan, Ayyalu Tanesh, Spahr Zachary, Taylor Allen
Keywords: Cardio-oncology, Cardiomyopathy, Monoclonal antibodies
02 : 00 PM
CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2 macrophages and CD8 T-cells
Jimenez Jesus, Amrute Junedh, Ma Pan, Wang Xiaoran, Dai Raymond, Lavine Kory
Final Pr. ID: BCVS7
Authors: Jimenez Jesus, Amrute Junedh, Ma Pan, Wang Xiaoran, Dai Raymond, Lavine Kory
Keywords: Cardio-oncology, Inflammation and inflammatory markers, Immunosuppressive therapy, Myocarditis, Monoclonal antibodies
Sun Yin, Huang Yuhsin, Chou Harrison, Vitale Maria Rosaria, Lin Zachary, Zhu Han
Final Pr. ID: Mo017
Authors: Sun Yin, Huang Yuhsin, Chou Harrison, Vitale Maria Rosaria, Lin Zachary, Zhu Han
Keywords: Myocarditis, Monoclonal antibodies, Cardio-oncology, Targeted therapeutics
07 : 00 PM
New Discoveries in Amyloid-Related Imaging Abnormalities with Hemorrhage (ARIA-H) and Anti-Amyloid Beta Monoclonal Antibodies
An Dinghao, Xu Yun
Final Pr. ID: TP214
Authors: An Dinghao, Xu Yun
Keywords: Amyloid angiopathy, Monoclonal antibodies, Drugs, Intracranial hemorrhage, Antibodies
09 : 57 AM
Platelet-derived growth factor antagonist antibody attenuates pulmonary arterial hypertension and prevents right heart dysfunction in the Sugen-Hypoxia rat model
Powers Kristi, Gao Yinglin, Preda Marilena, Sundaram Bharathi, Del Priore Isabella, Spencer Noakes Leigh, Quadri Nosirudeen, Walls Johnathon, Shekhar Akshay, Morton Lori
Final Pr. ID: MP1744
Authors: Powers Kristi, Gao Yinglin, Preda Marilena, Sundaram Bharathi, Del Priore Isabella, Spencer Noakes Leigh, Quadri Nosirudeen, Walls Johnathon, Shekhar Akshay, Morton Lori
Keywords: Pulmonary artery, Hypertension, Pulmonary hypertension, Monoclonal antibodies, Ventricular function
03 : 50 PM
The Impact of an Investigational First-In-Class Fully Human Natriuretic Peptide Receptor 1-Blocking Monoclonal Antibody REGN7544 on Systolic Blood Pressure and Hypovolemic and Hypotensive Disorders in Mice
Devalaraja-narashimha Kishor, Dunn Michael, Jin Ximei, Zhang Dongqin, Torello Justin, Mao Xia, Shekhar Akshay, Kim Jee, Franklin Matthew, Hernandez Annabel Romero, Ho Andre Jo-hao, Itani Hana, Kumar Mohit, Garnova Elena, Rafique Ashique, Krueger Pamela, Pan Hao, Wang Mao, Huang Tammy, Marin Ethan, Murphy Andrew, Yancopoulos George, Olenchock Benjamin, Olson William, Morton Lori
Final Pr. ID: MP1734
Authors: Devalaraja-narashimha Kishor, Dunn Michael, Jin Ximei, Zhang Dongqin, Torello Justin, Mao Xia, Shekhar Akshay, Kim Jee, Franklin Matthew, Hernandez Annabel Romero, Ho Andre Jo-hao, Itani Hana, Kumar Mohit, Garnova Elena, Rafique Ashique, Krueger Pamela, Pan Hao, Wang Mao, Huang Tammy, Marin Ethan, Murphy Andrew, Yancopoulos George, Olenchock Benjamin, Olson William, Morton Lori
Keywords: Natriuretic peptide, Monoclonal antibodies, Blood pressure
09 : 45 AM
Two Mechanistically Distinct Factor XI Antibodies, REGN9933 and REGN7508, for the Prevention of Venous Thromboembolism After Knee Arthroplasty: the ROXI-VTE-I and ROXI-VTE-II trials
Weitz Jeffrey, Kithcart Aaron, O'brien Meagan, Levy Oren, Marin Ethan, Onisko Malgorzata, Mohammadi Kusha, Li Dateng, Meagher Karoline, Olenchock Benjamin, Gutstein David, Segers Annelise, Roberts Robin, Bonaca Marc, Raskob Gary
Final Pr. ID: -
Authors: Weitz Jeffrey, Kithcart Aaron, O'brien Meagan, Levy Oren, Marin Ethan, Onisko Malgorzata, Mohammadi Kusha, Li Dateng, Meagher Karoline, Olenchock Benjamin, Gutstein David, Segers Annelise, Roberts Robin, Bonaca Marc, Raskob Gary
Keywords: Thrombosis, Anticoagulation, Antithrombotic therapy, Monoclonal antibodies, Venous thrombosis