Abstracts in Biological and Pragmatic Interventions in Heart Failure: From Present to Future, Scientific Sessions 2025

ANSWER-HF: A Randomized Controlled Trial of Sacubitril/Valsartan Versus Enalapril in Patients with Chronic Chagas Cardiomyopathy and Reduced Ejection Fraction

Madrini Junior Vagner, Antunes Talita, Damiani Lucas, Jose Grupi Cesar, Mathias Junior Wilson, Lopes Renato, Ramires Felix, Ramos Souza Paulo, Fernandes Fabio, Maria Ianni Barbara, Silva Martins Alan, JadÁn Luzuriaga Georgina Del Cisne, Cardoso Barbosa Fonseca Keila, Ribeiro Orlando, Bispo Da Cruz Allecineia

Final Pr. ID: -

Authors: Madrini Junior Vagner, Antunes Talita, Damiani Lucas, Jose Grupi Cesar, Mathias Junior Wilson, Lopes Renato, Ramires Felix, Ramos Souza Paulo, Fernandes Fabio, Maria Ianni Barbara, Silva Martins Alan, JadÁn Luzuriaga Georgina Del Cisne, Cardoso Barbosa Fonseca Keila, Ribeiro Orlando, Bispo Da Cruz Allecineia

Keywords: Heart failure , Cardiomyopathy , Ejection fraction , Arrhythmias , HFrEF

08 : 08 AM

Discussant: ANSWER-HF

Pfeffer Marc, Solomon Scott, Lopes Renato

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Authors: Pfeffer Marc, Solomon Scott, Lopes Renato

08 : 20 AM

Discussant: DAPA-EAT

Fontana Marianna, Raman Subha

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Authors: Fontana Marianna, Raman Subha

08 : 24 AM

Effect of Aficamten versus Metoprolol Monotherapy on Biomarkers in Obstructive Hypertrophic Cardiomyopathy: The MAPLE-HCM Trial

Lakdawala Neal, Burroughs Melissa, Claggett Brian, Costabel Juan, Correia Edileide, Dybro Anne, Elliott Perry, Kulac Ian, Lewis Gregory, Mann Amy, Nair Ajith, Garcia-pavia Pablo, Poulsen Steen, Reant Patricia, Schulze Christian, Solomon Scott, Wang Andrew, Sohn Regina, Berhane Indrias, Heitner Stephen, Jacoby Daniel, Kupfer Stuart, Maron Martin, Malik Fady, Wohltman Amy, Fifer Michael, Januzzi James, Masri Ahmad, Merkely Béla, Nassif Michael, Pena Pena Maria Luisa, Barriales-villa Roberto, Bilen Ozlem

Final Pr. ID: -

Authors: Lakdawala Neal, Burroughs Melissa, Claggett Brian, Costabel Juan, Correia Edileide, Dybro Anne, Elliott Perry, Kulac Ian, Lewis Gregory, Mann Amy, Nair Ajith, Garcia-pavia Pablo, Poulsen Steen, Reant Patricia, Schulze Christian, Solomon Scott, Wang Andrew, Sohn Regina, Berhane Indrias, Heitner Stephen, Jacoby Daniel, Kupfer Stuart, Maron Martin, Malik Fady, Wohltman Amy, Fifer Michael, Januzzi James, Masri Ahmad, Merkely Béla, Nassif Michael, Pena Pena Maria Luisa, Barriales-villa Roberto, Bilen Ozlem

Keywords: Biomarkers , Troponin , Hypertrophic cardiomyopathy , Beta-blocker

08 : 32 AM

Discussant: The MAPLE-HCM Trial

Day Sharlene

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Authors: Day Sharlene

08 : 36 AM

First-in-Human Gene Therapy Trial for Patients with Heart Failure with preserved Ejection Fraction (HFpEF)

Fudim Marat, Rudy Jeffrey, Guerrero Janet, Chan Camie, Patel Manesh, Bavry Anthony, Li Ronald, Sarma Satyam, Macnamara James, Levine Benjamin, Hajjar Roger, Ascheim Deborah, Grodin Justin, Kittipibul Veraprapas, Doukellis Katheryn, Dhimitri Andy, Fitzhugh Robert, Karmat Niharika, Costa Kevin

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Authors: Fudim Marat, Rudy Jeffrey, Guerrero Janet, Chan Camie, Patel Manesh, Bavry Anthony, Li Ronald, Sarma Satyam, Macnamara James, Levine Benjamin, Hajjar Roger, Ascheim Deborah, Grodin Justin, Kittipibul Veraprapas, Doukellis Katheryn, Dhimitri Andy, Fitzhugh Robert, Karmat Niharika, Costa Kevin

Keywords: Gene therapy , Heart failure , Diastolic function , Gene transfer

08 : 44 AM

Discussant: MUSIC-HFpEF

Kawana Masataka

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Authors: Kawana Masataka

08 : 48 AM

Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure - BioVAT-HF-DZHK20 – Phase II Interim Data Report

Ensminger Stephan, Fujita Buntaro, Gerecke Birgit, Hasenfuss Gerd, Hellenkamp Kristian, Herrmann-lingen Christoph, Jebran Ahmad-fawad, Jurczyk Dominik, Kowallick Johannes, Legler Tobias, Lotz Joachim, Kutschka Ingo, Placzek Marius, Puehler Thomas, Riggert Joachim, Sadlonova Monika, Tiburcy Malte, Zimmermann Wolfram, Paitazoglou Christina, Seidler Tim, Brandenburg Soeren, Anker Stefan, Bremmer Felix, Eitel Ingo, Friede Tim

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Authors: Ensminger Stephan, Fujita Buntaro, Gerecke Birgit, Hasenfuss Gerd, Hellenkamp Kristian, Herrmann-lingen Christoph, Jebran Ahmad-fawad, Jurczyk Dominik, Kowallick Johannes, Legler Tobias, Lotz Joachim, Kutschka Ingo, Placzek Marius, Puehler Thomas, Riggert Joachim, Sadlonova Monika, Tiburcy Malte, Zimmermann Wolfram, Paitazoglou Christina, Seidler Tim, Brandenburg Soeren, Anker Stefan, Bremmer Felix, Eitel Ingo, Friede Tim

Keywords: Tissue engineering , Stem cells , Heart failure , Regenerative medicine stem cells , Remodeling

08 : 56 AM

Discussant: BioVAT-HF DZHK20

Wu Joseph, Margulies Kenneth

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Authors: Wu Joseph, Margulies Kenneth

09 : 00 AM

Main Results of the Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure (COPILOT-HF) Program – A Pragmatic Randomized Study

Blood Alexander, Mcpartlin Marian, Wagholikar Kavishwar, Caberwal Harjeet, Cannon Christopher, Desai Akshay, Scirica Benjamin, Unlu Ozan, Hassan Shahzad, Nichols Hunter, Ostrominski John, Subramaniam Samantha, Zelle David, Figueroa Christian, Varugheese Matthew

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Authors: Blood Alexander, Mcpartlin Marian, Wagholikar Kavishwar, Caberwal Harjeet, Cannon Christopher, Desai Akshay, Scirica Benjamin, Unlu Ozan, Hassan Shahzad, Nichols Hunter, Ostrominski John, Subramaniam Samantha, Zelle David, Figueroa Christian, Varugheese Matthew

Keywords: Heart failure , adult , Guidelines