American Heart Association
Genomic Insights into Heritable Cardiomyopathies: From Disease Development to Novel Therapies
Moderated Digital Poster Session
Basic Science Zone, Moderated Digital Poster 25
Nov 10th , 12:15 PM - 01:15 PM
12 : 15 PM
A DHX38 Spliceosomal Mutation Impairs MYC Signaling, Cardiac Transcriptome Splicing, and Leads to Diastolic Dysfunction
Iwanski Jessika, Sarvagalla Sailu, Methawasin Mei, Van Den Berg Marloes, Churko Jared
Final Pr. ID: MP2725
Authors: Iwanski Jessika, Sarvagalla Sailu, Methawasin Mei, Van Den Berg Marloes, Churko Jared
Keywords: Cardiomyopathy , Transcriptomics , Proteomics , Diastolic function , HFpEF
12 : 22 PM
Impact of Disease-Causing Cardiomyopathy Variants on the Risk of Atrial Fibrillation and Ventricular Cardiomyopathies in the UK Biobank
Da Rocha Guilherme, Belley-cote Emilie, Conen David, Wong Jorge, Mcintyre William, Healey Jeff, Bezzina Connie, Watkins Hugh, Ware James, Tadros Rafik, Pare Guillaume, Feiner James, Roberts Jason, Lazarte Julieta, Pang Keona, Li Yanran, Le Ann, Man Alice, Pathan Nazia, Whitlock Richard
Final Pr. ID: MP2726
Authors: Da Rocha Guilherme, Belley-cote Emilie, Conen David, Wong Jorge, Mcintyre William, Healey Jeff, Bezzina Connie, Watkins Hugh, Ware James, Tadros Rafik, Pare Guillaume, Feiner James, Roberts Jason, Lazarte Julieta, Pang Keona, Li Yanran, Le Ann, Man Alice, Pathan Nazia, Whitlock Richard
Keywords: Atrial fibrillation , Cardiomyopathy , Polygenic Risk , Genetics
12 : 29 PM
A Suppression-and-Replacement Platform Identifies Pathogenic Variants in the LMNA-Encoded Lamin A/C Ig-Like Domain as Drivers of Nuclear Distortion and Aggregation
Huynh Trung, Kim Changsung, Tester David, Castrichini Matteo, Giudicessi John, Ackerman Michael
Final Pr. ID: MP2727
Authors: Huynh Trung, Kim Changsung, Tester David, Castrichini Matteo, Giudicessi John, Ackerman Michael
Keywords: Cardiomyopathy , Gene mutations , Genetic techniques , Stem cell biology
Wan Fangfang, Zhang Yu, Ma Bingxuan, Lu Minjie, Zhang Channa, Song Lei, Wang Jizheng
Final Pr. ID: MP2728
Authors: Wan Fangfang, Zhang Yu, Ma Bingxuan, Lu Minjie, Zhang Channa, Song Lei, Wang Jizheng
Keywords: Hypertrophic cardiomyopathy , Hypertrophy , Drugs , Ubiquitin , Transgenic models
12 : 43 PM
Regulatory Profiling of LMNA Identifies Therapeutic Targets for LMNA-Associated Dilated Cardiomyopathy
Viskadourou Maria, Beer Michael, Newby Gregory, Rojnuckarin Andrew, Xiao Jinghan, Saba Nicholas, Shoppell Elyse, Eckley D. Mark, Yates Bradley, Kim Yuri, Watkins Hugh
Final Pr. ID: MP2729
Authors: Viskadourou Maria, Beer Michael, Newby Gregory, Rojnuckarin Andrew, Xiao Jinghan, Saba Nicholas, Shoppell Elyse, Eckley D. Mark, Yates Bradley, Kim Yuri, Watkins Hugh
Keywords: Gene expression , Gene therapy , Cardiomyopathy , Arrhythmias , Transcriptomics
Staudt David, Parikh Victoria, Ashley Euan, Mercola Mark, Tran Peter, Floyd Brendan, Han Dongju, Jackson William, Carhuamaca Xiomara, Serrano Ricardo, Hnatiuk Anna, Cheng Paul
Final Pr. ID: MP2730
Authors: Staudt David, Parikh Victoria, Ashley Euan, Mercola Mark, Tran Peter, Floyd Brendan, Han Dongju, Jackson William, Carhuamaca Xiomara, Serrano Ricardo, Hnatiuk Anna, Cheng Paul
Keywords: Cardiomyopathy , Genetics , Diastolic function , Stem cells
12 : 57 PM
Penetrance of Cardiomyopathy-Associated Variants in a Population-Based Cohort Supports ClinGen Gene Validity Classifications
Wolfe Rachel, Yadav Kanishk, Ma Elisa, Balint Brittany, Gurumoorthi Manasa, Sharaf Dabbagh Ghaith, Ingles Jodie, Chahal Anwar, Landstrom Andrew
Final Pr. ID: MP2731
Authors: Wolfe Rachel, Yadav Kanishk, Ma Elisa, Balint Brittany, Gurumoorthi Manasa, Sharaf Dabbagh Ghaith, Ingles Jodie, Chahal Anwar, Landstrom Andrew
Keywords: Cardiomyopathy , Genetics
01 : 04 PM
Machine Learning For Precision Phenotyping and Genomic Discovery for Heart Failure with Preserved Ejection Fraction
Osullivan Jack, Yun Taedong, Mcclean Cory, Hormozdiari Farhad, Carroll Andrew, Ashley Euan
Final Pr. ID: MP2732
Authors: Osullivan Jack, Yun Taedong, Mcclean Cory, Hormozdiari Farhad, Carroll Andrew, Ashley Euan
Keywords: Genomics , Genome-wide association studies (GWAS) , Heart failure , adult , Artificial Intelligence
12 : 15 PM
A DHX38 Spliceosomal Mutation Impairs MYC Signaling, Cardiac Transcriptome Splicing, and Leads to Diastolic Dysfunction
Iwanski Jessika, Sarvagalla Sailu, Methawasin Mei, Van Den Berg Marloes, Churko Jared
Final Pr. ID: MP2725
Authors: Iwanski Jessika, Sarvagalla Sailu, Methawasin Mei, Van Den Berg Marloes, Churko Jared
Keywords: Cardiomyopathy , Transcriptomics , Proteomics , Diastolic function , HFpEF
12 : 29 PM
A Suppression-and-Replacement Platform Identifies Pathogenic Variants in the LMNA-Encoded Lamin A/C Ig-Like Domain as Drivers of Nuclear Distortion and Aggregation
Huynh Trung, Kim Changsung, Tester David, Castrichini Matteo, Giudicessi John, Ackerman Michael
Final Pr. ID: MP2727
Authors: Huynh Trung, Kim Changsung, Tester David, Castrichini Matteo, Giudicessi John, Ackerman Michael
Keywords: Cardiomyopathy , Gene mutations , Genetic techniques , Stem cell biology
Wan Fangfang, Zhang Yu, Ma Bingxuan, Lu Minjie, Zhang Channa, Song Lei, Wang Jizheng
Final Pr. ID: MP2728
Authors: Wan Fangfang, Zhang Yu, Ma Bingxuan, Lu Minjie, Zhang Channa, Song Lei, Wang Jizheng
Keywords: Hypertrophic cardiomyopathy , Hypertrophy , Drugs , Ubiquitin , Transgenic models
12 : 22 PM
Impact of Disease-Causing Cardiomyopathy Variants on the Risk of Atrial Fibrillation and Ventricular Cardiomyopathies in the UK Biobank
Da Rocha Guilherme, Belley-cote Emilie, Conen David, Wong Jorge, Mcintyre William, Healey Jeff, Bezzina Connie, Watkins Hugh, Ware James, Tadros Rafik, Pare Guillaume, Feiner James, Roberts Jason, Lazarte Julieta, Pang Keona, Li Yanran, Le Ann, Man Alice, Pathan Nazia, Whitlock Richard
Final Pr. ID: MP2726
Authors: Da Rocha Guilherme, Belley-cote Emilie, Conen David, Wong Jorge, Mcintyre William, Healey Jeff, Bezzina Connie, Watkins Hugh, Ware James, Tadros Rafik, Pare Guillaume, Feiner James, Roberts Jason, Lazarte Julieta, Pang Keona, Li Yanran, Le Ann, Man Alice, Pathan Nazia, Whitlock Richard
Keywords: Atrial fibrillation , Cardiomyopathy , Polygenic Risk , Genetics
01 : 04 PM
Machine Learning For Precision Phenotyping and Genomic Discovery for Heart Failure with Preserved Ejection Fraction
Osullivan Jack, Yun Taedong, Mcclean Cory, Hormozdiari Farhad, Carroll Andrew, Ashley Euan
Final Pr. ID: MP2732
Authors: Osullivan Jack, Yun Taedong, Mcclean Cory, Hormozdiari Farhad, Carroll Andrew, Ashley Euan
Keywords: Genomics , Genome-wide association studies (GWAS) , Heart failure , adult , Artificial Intelligence
Staudt David, Parikh Victoria, Ashley Euan, Mercola Mark, Tran Peter, Floyd Brendan, Han Dongju, Jackson William, Carhuamaca Xiomara, Serrano Ricardo, Hnatiuk Anna, Cheng Paul
Final Pr. ID: MP2730
Authors: Staudt David, Parikh Victoria, Ashley Euan, Mercola Mark, Tran Peter, Floyd Brendan, Han Dongju, Jackson William, Carhuamaca Xiomara, Serrano Ricardo, Hnatiuk Anna, Cheng Paul
Keywords: Cardiomyopathy , Genetics , Diastolic function , Stem cells
12 : 57 PM
Penetrance of Cardiomyopathy-Associated Variants in a Population-Based Cohort Supports ClinGen Gene Validity Classifications
Wolfe Rachel, Yadav Kanishk, Ma Elisa, Balint Brittany, Gurumoorthi Manasa, Sharaf Dabbagh Ghaith, Ingles Jodie, Chahal Anwar, Landstrom Andrew
Final Pr. ID: MP2731
Authors: Wolfe Rachel, Yadav Kanishk, Ma Elisa, Balint Brittany, Gurumoorthi Manasa, Sharaf Dabbagh Ghaith, Ingles Jodie, Chahal Anwar, Landstrom Andrew
Keywords: Cardiomyopathy , Genetics
12 : 43 PM
Regulatory Profiling of LMNA Identifies Therapeutic Targets for LMNA-Associated Dilated Cardiomyopathy
Viskadourou Maria, Beer Michael, Newby Gregory, Rojnuckarin Andrew, Xiao Jinghan, Saba Nicholas, Shoppell Elyse, Eckley D. Mark, Yates Bradley, Kim Yuri, Watkins Hugh
Final Pr. ID: MP2729
Authors: Viskadourou Maria, Beer Michael, Newby Gregory, Rojnuckarin Andrew, Xiao Jinghan, Saba Nicholas, Shoppell Elyse, Eckley D. Mark, Yates Bradley, Kim Yuri, Watkins Hugh
Keywords: Gene expression , Gene therapy , Cardiomyopathy , Arrhythmias , Transcriptomics