American Heart Association
Late-Breaking Basic Science: Exploring New Therapeutic Horizons for Cardiometabolic Disease: Before Phase 0
Abstract Oral Session
S102BC
Nov 16th , 01:30 PM - 02:45 PM
01 : 30 PM
A Novel CRISPR based Epigenetic Silencer Potently, Durably, and Safely Reduces LDLc in Non-Human Primates at Therapeutically Relevant Doses
Duncan-lewis Christopher, Narsineni Lokesh, Karmarkar Maitreyee, Li Yuexuan, Krupa Oleh, Bucher Simon, Sharma Neel, Chang Han, Schulwach Keith, Ripley-phipps Sterling, Tran Vanessa, Fernandes Jason, Goh Natalie, Deiter Fred, Reimer Kirsten, Mrak Anna, Eggers Michelle, Sze Christie, Mirotsou Maria, Oresic Bender Kristina, Bardai Farah, Denny Sarah, Charles Emeric, Khakoo Aarif, Oakes Benjamin, Keller Steven, Alcantara-lee Raniel, Santamaria Carlos, Bale Shyam Sundhar, Kozy Heather, Corbo Lana
Final Pr. ID: 4172282
Authors: Duncan-lewis Christopher, Narsineni Lokesh, Karmarkar Maitreyee, Li Yuexuan, Krupa Oleh, Bucher Simon, Sharma Neel, Chang Han, Schulwach Keith, Ripley-phipps Sterling, Tran Vanessa, Fernandes Jason, Goh Natalie, Deiter Fred, Reimer Kirsten, Mrak Anna, Eggers Michelle, Sze Christie, Mirotsou Maria, Oresic Bender Kristina, Bardai Farah, Denny Sarah, Charles Emeric, Khakoo Aarif, Oakes Benjamin, Keller Steven, Alcantara-lee Raniel, Santamaria Carlos, Bale Shyam Sundhar, Kozy Heather, Corbo Lana
Keywords: Epigenetics , Cholesterol-lowering drugs , Cardiovascular disease , PCSK9 , LDL
01 : 45 PM
Cellularized Tissue-Engineered Biological Ventricular Assist Devices Improve Global Cardiac Function in a Porcine Model of Ischemic Cardiomyopathy
Wu Ming, Gillijns Hilde, Holemans Patricia, Ginkels Mieke, Dokter Inge, Jungst Tomasz, Sluijter Joost, Groll Jürgen, Mazo Vega Manuel, Serra Margarida, Prosper Felipe, Oosterlinck Wouter, Janssens Stefan, Vincente Pedro, Claus Piet, Algoet Michiel, Braig Johannes, Van Mil Alain, Iglesias Garcia Olalla, Del Pilar Montero Calle Maria
Final Pr. ID: 4166524
Authors: Wu Ming, Gillijns Hilde, Holemans Patricia, Ginkels Mieke, Dokter Inge, Jungst Tomasz, Sluijter Joost, Groll Jürgen, Mazo Vega Manuel, Serra Margarida, Prosper Felipe, Oosterlinck Wouter, Janssens Stefan, Vincente Pedro, Claus Piet, Algoet Michiel, Braig Johannes, Van Mil Alain, Iglesias Garcia Olalla, Del Pilar Montero Calle Maria
Keywords: Regenerative medicine stem cells , Tissue engineering , Cardiomyopathy
Ahmed Mahmoud, Nozohouri Ehsan, Thompson Jonathan, Bickel Ulrich, Chelikani Prasanth, Farag Ayman, Tareq Syed Mohammed, Ewida Heba, Zoubi Sumaih, Benson Harrison, Patel Dhavalkumar, Diab Hanin, Patra Souvik, Redrovan Daniella
Final Pr. ID: 4171464
Authors: Ahmed Mahmoud, Nozohouri Ehsan, Thompson Jonathan, Bickel Ulrich, Chelikani Prasanth, Farag Ayman, Tareq Syed Mohammed, Ewida Heba, Zoubi Sumaih, Benson Harrison, Patel Dhavalkumar, Diab Hanin, Patra Souvik, Redrovan Daniella
Keywords: Obesity , Diabetes (Type II) , Metabolism , Dose-response relation , drug , Signal transduction
02 : 15 PM
Biodistribution of Systemically Administered Lab-grown, 3D Extracellular Matrix Particles and Their Effects on Post-Myocardial Infarction Cardiac Function
Broadwin Mark, Abid Ruhul, St Angelo Katerina, Petersen Max, Brinck Teixeira Rayane, Harris Dwight, Stone Christopher, Xu Cynthia, Sellke Frank, Morgan Jeffrey
Final Pr. ID: 4172104
Authors: Broadwin Mark, Abid Ruhul, St Angelo Katerina, Petersen Max, Brinck Teixeira Rayane, Harris Dwight, Stone Christopher, Xu Cynthia, Sellke Frank, Morgan Jeffrey
Keywords: Myocardial infarction , Extracellular matrix , Infarct size , Angiogenesis , Proteome
02 : 30 PM
COMBINATION THERAPY WITH SEMAGLUTIDE AND INCLISIRAN REDUCES SYNERGISTICALLY ANTHRACYCLINE-INDUCED CARDIOTOXICITY UNDER HYPERLIPIDEMIA : NEW EVIDENCES IN PREVENTION OF CTRCD IN CANCER PATIENTS
Maurea Nicola, Quagliariello Vincenzo, Giacobbe Ilaria, Giordano Vienna, Izzo Francesca, Arianna Raffaele, Barbato Matteo, Maurea Carlo
Final Pr. ID: 4170156
Authors: Maurea Nicola, Quagliariello Vincenzo, Giacobbe Ilaria, Giordano Vienna, Izzo Francesca, Arianna Raffaele, Barbato Matteo, Maurea Carlo
Keywords: Cardio-oncology
01 : 30 PM
A Novel CRISPR based Epigenetic Silencer Potently, Durably, and Safely Reduces LDLc in Non-Human Primates at Therapeutically Relevant Doses
Duncan-lewis Christopher, Narsineni Lokesh, Karmarkar Maitreyee, Li Yuexuan, Krupa Oleh, Bucher Simon, Sharma Neel, Chang Han, Schulwach Keith, Ripley-phipps Sterling, Tran Vanessa, Fernandes Jason, Goh Natalie, Deiter Fred, Reimer Kirsten, Mrak Anna, Eggers Michelle, Sze Christie, Mirotsou Maria, Oresic Bender Kristina, Bardai Farah, Denny Sarah, Charles Emeric, Khakoo Aarif, Oakes Benjamin, Keller Steven, Alcantara-lee Raniel, Santamaria Carlos, Bale Shyam Sundhar, Kozy Heather, Corbo Lana
Final Pr. ID: 4172282
Authors: Duncan-lewis Christopher, Narsineni Lokesh, Karmarkar Maitreyee, Li Yuexuan, Krupa Oleh, Bucher Simon, Sharma Neel, Chang Han, Schulwach Keith, Ripley-phipps Sterling, Tran Vanessa, Fernandes Jason, Goh Natalie, Deiter Fred, Reimer Kirsten, Mrak Anna, Eggers Michelle, Sze Christie, Mirotsou Maria, Oresic Bender Kristina, Bardai Farah, Denny Sarah, Charles Emeric, Khakoo Aarif, Oakes Benjamin, Keller Steven, Alcantara-lee Raniel, Santamaria Carlos, Bale Shyam Sundhar, Kozy Heather, Corbo Lana
Keywords: Epigenetics , Cholesterol-lowering drugs , Cardiovascular disease , PCSK9 , LDL
02 : 15 PM
Biodistribution of Systemically Administered Lab-grown, 3D Extracellular Matrix Particles and Their Effects on Post-Myocardial Infarction Cardiac Function
Broadwin Mark, Abid Ruhul, St Angelo Katerina, Petersen Max, Brinck Teixeira Rayane, Harris Dwight, Stone Christopher, Xu Cynthia, Sellke Frank, Morgan Jeffrey
Final Pr. ID: 4172104
Authors: Broadwin Mark, Abid Ruhul, St Angelo Katerina, Petersen Max, Brinck Teixeira Rayane, Harris Dwight, Stone Christopher, Xu Cynthia, Sellke Frank, Morgan Jeffrey
Keywords: Myocardial infarction , Extracellular matrix , Infarct size , Angiogenesis , Proteome
01 : 45 PM
Cellularized Tissue-Engineered Biological Ventricular Assist Devices Improve Global Cardiac Function in a Porcine Model of Ischemic Cardiomyopathy
Wu Ming, Gillijns Hilde, Holemans Patricia, Ginkels Mieke, Dokter Inge, Jungst Tomasz, Sluijter Joost, Groll Jürgen, Mazo Vega Manuel, Serra Margarida, Prosper Felipe, Oosterlinck Wouter, Janssens Stefan, Vincente Pedro, Claus Piet, Algoet Michiel, Braig Johannes, Van Mil Alain, Iglesias Garcia Olalla, Del Pilar Montero Calle Maria
Final Pr. ID: 4166524
Authors: Wu Ming, Gillijns Hilde, Holemans Patricia, Ginkels Mieke, Dokter Inge, Jungst Tomasz, Sluijter Joost, Groll Jürgen, Mazo Vega Manuel, Serra Margarida, Prosper Felipe, Oosterlinck Wouter, Janssens Stefan, Vincente Pedro, Claus Piet, Algoet Michiel, Braig Johannes, Van Mil Alain, Iglesias Garcia Olalla, Del Pilar Montero Calle Maria
Keywords: Regenerative medicine stem cells , Tissue engineering , Cardiomyopathy
02 : 30 PM
COMBINATION THERAPY WITH SEMAGLUTIDE AND INCLISIRAN REDUCES SYNERGISTICALLY ANTHRACYCLINE-INDUCED CARDIOTOXICITY UNDER HYPERLIPIDEMIA : NEW EVIDENCES IN PREVENTION OF CTRCD IN CANCER PATIENTS
Maurea Nicola, Quagliariello Vincenzo, Giacobbe Ilaria, Giordano Vienna, Izzo Francesca, Arianna Raffaele, Barbato Matteo, Maurea Carlo
Final Pr. ID: 4170156
Authors: Maurea Nicola, Quagliariello Vincenzo, Giacobbe Ilaria, Giordano Vienna, Izzo Francesca, Arianna Raffaele, Barbato Matteo, Maurea Carlo
Keywords: Cardio-oncology
Ahmed Mahmoud, Nozohouri Ehsan, Thompson Jonathan, Bickel Ulrich, Chelikani Prasanth, Farag Ayman, Tareq Syed Mohammed, Ewida Heba, Zoubi Sumaih, Benson Harrison, Patel Dhavalkumar, Diab Hanin, Patra Souvik, Redrovan Daniella
Final Pr. ID: 4171464
Authors: Ahmed Mahmoud, Nozohouri Ehsan, Thompson Jonathan, Bickel Ulrich, Chelikani Prasanth, Farag Ayman, Tareq Syed Mohammed, Ewida Heba, Zoubi Sumaih, Benson Harrison, Patel Dhavalkumar, Diab Hanin, Patra Souvik, Redrovan Daniella
Keywords: Obesity , Diabetes (Type II) , Metabolism , Dose-response relation , drug , Signal transduction