American Heart Association
Genomic Therapies for Cardiovascular Disease
Moderated Digital Poster Session
Zone 1, Moderated Digital Poster 2
Nov 16th , 09:30 AM - 10:45 AM
09 : 30 AM
Engineering and Development of Optimal CRISPR Based Genome Modification Molecules for Safe and Effective LDL-C Lowering
Duncan-lewis Christopher, Colin Isabel, Corbo Lana, Deiter Fred, Demaree Benjamin, Denny Sarah, Fernandes Jason, Gardner Matthew, Hadaczek Piotr, Hochman Myles, Hsu Bernadette, Harms Matthew, Karanth Santhosh, Karmarkar Maitreyee, Keller Steven, Kozy Heather, Krupa Oleh, Leeman Dena, Li Yuexuan, Mirotsou Maria, Mok Amanda, Mrak Anna, Adil Maroof, Narsineni Lokesh, Ripley-phipps Sterling, Reimer Kirsten, Szulwach Keith, Shroff Shilpa, Tran Vanessa, Tung Kuei-ling, Wright Addison, Oakes Benjamin, Khakoo Aarif, Alcantra-lee Raniel, Bardai Farah, Oresic Bender Kristina, Bale Shyam Sundhar, Charles Emeric, Chen Kai-yuan
Final Pr. ID: MDP34
Authors: Duncan-lewis Christopher, Colin Isabel, Corbo Lana, Deiter Fred, Demaree Benjamin, Denny Sarah, Fernandes Jason, Gardner Matthew, Hadaczek Piotr, Hochman Myles, Hsu Bernadette, Harms Matthew, Karanth Santhosh, Karmarkar Maitreyee, Keller Steven, Kozy Heather, Krupa Oleh, Leeman Dena, Li Yuexuan, Mirotsou Maria, Mok Amanda, Mrak Anna, Adil Maroof, Narsineni Lokesh, Ripley-phipps Sterling, Reimer Kirsten, Szulwach Keith, Shroff Shilpa, Tran Vanessa, Tung Kuei-ling, Wright Addison, Oakes Benjamin, Khakoo Aarif, Alcantra-lee Raniel, Bardai Farah, Oresic Bender Kristina, Bale Shyam Sundhar, Charles Emeric, Chen Kai-yuan
Keywords: Genetic techniques , Hyperlipidemia , PCSK9 , Cardiovascular disease , Drugs
09 : 40 AM
Identification of ANGPTL4 and ITGAV as Therapeutic Targets for Calcific Aortic Valve Disease through Comprehensive Mendelian Randomization Using Human Plasma Proteome
Lu Jin, Xu Dilin, Hu Haochang, Qian Ningjing, Liu Xianbao, Wang Jianan
Final Pr. ID: MDP35
Authors: Lu Jin, Xu Dilin, Hu Haochang, Qian Ningjing, Liu Xianbao, Wang Jianan
Keywords: Aortic valve stenosis , Calcification , Genome-wide association studies (GWAS)
09 : 50 AM
Apical resection preserves the proliferative capacity of cardiomyocytes located throughout the left ventricle of the heart
Nguyen Thanh, Nakada Yuji, Wei Yuhua, Zhang Jianyi
Final Pr. ID: MDP36
Authors: Nguyen Thanh, Nakada Yuji, Wei Yuhua, Zhang Jianyi
Keywords: Cardiac regeneration , Myocardial infarction , Genomics , Machine Learning
10 : 05 AM
Functional characterization of GWAS findings highlights the protective role of REST against atherosclerosis
Viskadourou Maria, Osburn William, Mccallion Andrew, Battle Alexis, Lowenstein Charles, Arvanitis Marios, Reventun Paula, Chaudhry Sharjeel, Alcharani Nunzio, Toledano Sanz Pablo, Villapudua Gastelum Carlos, Lopez-cecetaite Gabriel, Fennell Abigail, An Roujin
Final Pr. ID: MDP37
Authors: Viskadourou Maria, Osburn William, Mccallion Andrew, Battle Alexis, Lowenstein Charles, Arvanitis Marios, Reventun Paula, Chaudhry Sharjeel, Alcharani Nunzio, Toledano Sanz Pablo, Villapudua Gastelum Carlos, Lopez-cecetaite Gabriel, Fennell Abigail, An Roujin
Keywords: Genome-wide association studies (GWAS) , Atherosclerosis , Endothelial function , Transcriptomics , Genomics
10 : 15 AM
Retrospective study shows pharmacogenomic testing could reduce adverse events associated with clopidogrel use by 38%
Washington Nicole, Telis Natalie, Judge Daniel, Pawloski Pamala, Grzymski Joseph, Chahal Anwar, Hajek Catherine, Kruisselbrink Teresa, Cirulli Elizabeth
Final Pr. ID: MDP38
Authors: Washington Nicole, Telis Natalie, Judge Daniel, Pawloski Pamala, Grzymski Joseph, Chahal Anwar, Hajek Catherine, Kruisselbrink Teresa, Cirulli Elizabeth
Keywords: Clopidogrel , Thrombosis
10 : 25 AM
A drug target Mendelian randomization study of triglyceride lowering therapies for aortic stenosis
Ciofani Jonathan, Han Daniel, Gill Dipender, Rao Karan, Allahwala Usaid, Bhindi Ravinay
Final Pr. ID: MDP39
Authors: Ciofani Jonathan, Han Daniel, Gill Dipender, Rao Karan, Allahwala Usaid, Bhindi Ravinay
Keywords: Aortic valve stenosis , Lipids , Genome-wide association studies (GWAS) , LDL , Triglycerides
10 : 35 AM
Design of Heart-2: a phase 1b clinical trial of VERVE-102, an in vivo base editing medicine delivered by a GalNAc-LNP and targeting PCSK9 to durably lower LDL cholesterol
Vafai Scott, Fiedorek Fred, Karsten Verena, Jensen Chelsey, Falzone Richard, Lister Troy, Stolz Leslie, Khera Amit, Kathiresan Sekar, Bellinger Andrew
Final Pr. ID: MDP40
Authors: Vafai Scott, Fiedorek Fred, Karsten Verena, Jensen Chelsey, Falzone Richard, Lister Troy, Stolz Leslie, Khera Amit, Kathiresan Sekar, Bellinger Andrew
Keywords: Gene therapy , Hypercholesterolemia , Atherosclerosis , Lipids , Targeted therapeutics
10 : 25 AM
A drug target Mendelian randomization study of triglyceride lowering therapies for aortic stenosis
Ciofani Jonathan, Han Daniel, Gill Dipender, Rao Karan, Allahwala Usaid, Bhindi Ravinay
Final Pr. ID: MDP39
Authors: Ciofani Jonathan, Han Daniel, Gill Dipender, Rao Karan, Allahwala Usaid, Bhindi Ravinay
Keywords: Aortic valve stenosis , Lipids , Genome-wide association studies (GWAS) , LDL , Triglycerides
09 : 50 AM
Apical resection preserves the proliferative capacity of cardiomyocytes located throughout the left ventricle of the heart
Nguyen Thanh, Nakada Yuji, Wei Yuhua, Zhang Jianyi
Final Pr. ID: MDP36
Authors: Nguyen Thanh, Nakada Yuji, Wei Yuhua, Zhang Jianyi
Keywords: Cardiac regeneration , Myocardial infarction , Genomics , Machine Learning
10 : 35 AM
Design of Heart-2: a phase 1b clinical trial of VERVE-102, an in vivo base editing medicine delivered by a GalNAc-LNP and targeting PCSK9 to durably lower LDL cholesterol
Vafai Scott, Fiedorek Fred, Karsten Verena, Jensen Chelsey, Falzone Richard, Lister Troy, Stolz Leslie, Khera Amit, Kathiresan Sekar, Bellinger Andrew
Final Pr. ID: MDP40
Authors: Vafai Scott, Fiedorek Fred, Karsten Verena, Jensen Chelsey, Falzone Richard, Lister Troy, Stolz Leslie, Khera Amit, Kathiresan Sekar, Bellinger Andrew
Keywords: Gene therapy , Hypercholesterolemia , Atherosclerosis , Lipids , Targeted therapeutics
09 : 30 AM
Engineering and Development of Optimal CRISPR Based Genome Modification Molecules for Safe and Effective LDL-C Lowering
Duncan-lewis Christopher, Colin Isabel, Corbo Lana, Deiter Fred, Demaree Benjamin, Denny Sarah, Fernandes Jason, Gardner Matthew, Hadaczek Piotr, Hochman Myles, Hsu Bernadette, Harms Matthew, Karanth Santhosh, Karmarkar Maitreyee, Keller Steven, Kozy Heather, Krupa Oleh, Leeman Dena, Li Yuexuan, Mirotsou Maria, Mok Amanda, Mrak Anna, Adil Maroof, Narsineni Lokesh, Ripley-phipps Sterling, Reimer Kirsten, Szulwach Keith, Shroff Shilpa, Tran Vanessa, Tung Kuei-ling, Wright Addison, Oakes Benjamin, Khakoo Aarif, Alcantra-lee Raniel, Bardai Farah, Oresic Bender Kristina, Bale Shyam Sundhar, Charles Emeric, Chen Kai-yuan
Final Pr. ID: MDP34
Authors: Duncan-lewis Christopher, Colin Isabel, Corbo Lana, Deiter Fred, Demaree Benjamin, Denny Sarah, Fernandes Jason, Gardner Matthew, Hadaczek Piotr, Hochman Myles, Hsu Bernadette, Harms Matthew, Karanth Santhosh, Karmarkar Maitreyee, Keller Steven, Kozy Heather, Krupa Oleh, Leeman Dena, Li Yuexuan, Mirotsou Maria, Mok Amanda, Mrak Anna, Adil Maroof, Narsineni Lokesh, Ripley-phipps Sterling, Reimer Kirsten, Szulwach Keith, Shroff Shilpa, Tran Vanessa, Tung Kuei-ling, Wright Addison, Oakes Benjamin, Khakoo Aarif, Alcantra-lee Raniel, Bardai Farah, Oresic Bender Kristina, Bale Shyam Sundhar, Charles Emeric, Chen Kai-yuan
Keywords: Genetic techniques , Hyperlipidemia , PCSK9 , Cardiovascular disease , Drugs
10 : 05 AM
Functional characterization of GWAS findings highlights the protective role of REST against atherosclerosis
Viskadourou Maria, Osburn William, Mccallion Andrew, Battle Alexis, Lowenstein Charles, Arvanitis Marios, Reventun Paula, Chaudhry Sharjeel, Alcharani Nunzio, Toledano Sanz Pablo, Villapudua Gastelum Carlos, Lopez-cecetaite Gabriel, Fennell Abigail, An Roujin
Final Pr. ID: MDP37
Authors: Viskadourou Maria, Osburn William, Mccallion Andrew, Battle Alexis, Lowenstein Charles, Arvanitis Marios, Reventun Paula, Chaudhry Sharjeel, Alcharani Nunzio, Toledano Sanz Pablo, Villapudua Gastelum Carlos, Lopez-cecetaite Gabriel, Fennell Abigail, An Roujin
Keywords: Genome-wide association studies (GWAS) , Atherosclerosis , Endothelial function , Transcriptomics , Genomics
09 : 40 AM
Identification of ANGPTL4 and ITGAV as Therapeutic Targets for Calcific Aortic Valve Disease through Comprehensive Mendelian Randomization Using Human Plasma Proteome
Lu Jin, Xu Dilin, Hu Haochang, Qian Ningjing, Liu Xianbao, Wang Jianan
Final Pr. ID: MDP35
Authors: Lu Jin, Xu Dilin, Hu Haochang, Qian Ningjing, Liu Xianbao, Wang Jianan
Keywords: Aortic valve stenosis , Calcification , Genome-wide association studies (GWAS)
10 : 15 AM
Retrospective study shows pharmacogenomic testing could reduce adverse events associated with clopidogrel use by 38%
Washington Nicole, Telis Natalie, Judge Daniel, Pawloski Pamala, Grzymski Joseph, Chahal Anwar, Hajek Catherine, Kruisselbrink Teresa, Cirulli Elizabeth
Final Pr. ID: MDP38
Authors: Washington Nicole, Telis Natalie, Judge Daniel, Pawloski Pamala, Grzymski Joseph, Chahal Anwar, Hajek Catherine, Kruisselbrink Teresa, Cirulli Elizabeth
Keywords: Clopidogrel , Thrombosis