Showing 11 Abstracts.
02 : 00 PM
A Beta Tubulin Mutation Suppresses Arrhythmias and Improves Connexin 43 Localization in Heart of Duchenne Muscular Dystrophy Mice
Zhou Delong, Nouet Julie, Mesa Elam, Yegneshwaran Vasisht, Geukgeuzian Geovanni, Adibemma Ifeanyichukwu, Nandakumar Swetha, Ramirez Edwin, Li Hong, Liu Tong, Yehia Ghassan, Romanienko Peter, Rodney George, Wehrens Xander, Lampe Paul, Gourdie Robert, Xie Lai-hua, Fraidenraich Diego
Final Pr. ID: BCVS6
Authors: Zhou Delong, Nouet Julie, Mesa Elam, Yegneshwaran Vasisht, Geukgeuzian Geovanni, Adibemma Ifeanyichukwu, Nandakumar Swetha, Ramirez Edwin, Li Hong, Liu Tong, Yehia Ghassan, Romanienko Peter, Rodney George, Wehrens Xander, Lampe Paul, Gourdie Robert, Xie Lai-hua, Fraidenraich Diego
Keywords: Arrhythmias, Connexin, Cytoskeleton, Dystrophin, Cardiomyopathy
04 : 30 PM
AI Modeling Predicts BI 749327 disrupts Transient Receptor Potential Canonical 6 channel formation to rescue dystrophic cardiomyopathy
Brusacoram Annabelle, Guru Sameer, Nunez Raymundo, Smith Brian, Lin Brian
Final Pr. ID: Fri004
Authors: Brusacoram Annabelle, Guru Sameer, Nunez Raymundo, Smith Brian, Lin Brian
Keywords: Dystrophin, Cardiomyopathy, Ion channels, Artificial Intelligence, Computational modeling
09 : 50 AM
Cardiac Specific Biomarkers of Progression in Duchenne Muscular Dystrophy Detected Using Aptamer-Based Proteomics
Naguib Mark, Tamaroff Jaclyn, Burnette William, Harris Rachel, Xu Meng, Slaughter James, Markham Larry, Soslow Jonathan
Final Pr. ID: MDP829
Authors: Naguib Mark, Tamaroff Jaclyn, Burnette William, Harris Rachel, Xu Meng, Slaughter James, Markham Larry, Soslow Jonathan
Keywords: Dystrophin, Proteomics, Cardiomyopathy, Children, Cardiac MRI
04 : 30 PM
Elucidation of the mechanism of DMD cardiomyopathy with the use of a FRET-based sarcomere activation biosensor
Martin Ashley, Metzger Joseph
Final Pr. ID: Wed127
Authors: Martin Ashley, Metzger Joseph
Keywords: Troponin, Sarcomere, Myosin, Contractile proteins, Dystrophin
04 : 30 PM
Exon-skipping therapy can restore functional dystrophin attenuating calcium overload for DMD cardiomyopathy with mutations in actin-binding domain 1
Shiba Naoko, Yang Xiao, Agata Masahiro, Nagamine Kohei, Kadota Shin, Mitsuto Sato, Nakamura Akinori, Shiba Yuji
Final Pr. ID: We048
Authors: Shiba Naoko, Yang Xiao, Agata Masahiro, Nagamine Kohei, Kadota Shin, Mitsuto Sato, Nakamura Akinori, Shiba Yuji
Keywords: Cardiomyopathy, Dystrophin, Stem cells
04 : 04 PM
Fat Mass and Systolic Blood Pressure are Modifiable CV Risk Factors Associated with Adverse Myocardial Changes in Patients with Duchenne Muscular Dystrophy
Sill Jordan, Greiner Eleanor, Urbina Elaine, Villa Chet
Final Pr. ID: MP1618
Authors: Sill Jordan, Greiner Eleanor, Urbina Elaine, Villa Chet
Keywords: Ventricular remodeling, Blood pressure, Cardiovascular Risk, Dystrophin, Overweight and obesity
04 : 30 PM
Microdystrophins Partially Rescue Duchenne Muscular Dystrophy Deficits in iPSC-Cardiomyocytes
Keegan Abiageal, Gonzalez Adriana Fernanda, Zhang Rongruo, Doan Hung, Torres-bigio Sofia, Lau Fiona, Ly Kaulen, Lai Elaine, Mamuyac Leahlyn, Eguchi Asuka
Final Pr. ID: Wed155
Authors: Keegan Abiageal, Gonzalez Adriana Fernanda, Zhang Rongruo, Doan Hung, Torres-bigio Sofia, Lau Fiona, Ly Kaulen, Lai Elaine, Mamuyac Leahlyn, Eguchi Asuka
Keywords: Targeted therapeutics, Dystrophin, Heart failure, pediatric
09 : 15 AM
Phospho-Mimic Mutation in Beta Tubulin Suppresses Arrhythmias and Improves Cardiac Connexin 43 Localization in Duchenne Muscular Dystrophy Mice
Zhou Delong, Nouet Julie, Mesa Elam, Geukgeuzian Geovanni, Li Hong, Liu Tong, Yehia Ghassan, Romanienko Peter, Rodney George, Wehrens Xander, Lampe Paul, Gourdie Robert, Xie Lai-hua, Fraidenraich Diego
Final Pr. ID: Or101
Authors: Zhou Delong, Nouet Julie, Mesa Elam, Geukgeuzian Geovanni, Li Hong, Liu Tong, Yehia Ghassan, Romanienko Peter, Rodney George, Wehrens Xander, Lampe Paul, Gourdie Robert, Xie Lai-hua, Fraidenraich Diego
Keywords: Dystrophin, Connexin, Arrhythmias
11 : 20 AM
S-nitrosylation of cardiac Cx43 hemichannels at Cys271 promotes arrhythmogenicity and myocardial injury upon cardiac stress in Duchenne Muscular Dystrophy
Munoz Camus Manuel, Quan Jonathan, Nguyen Thao, Nuno Janet, Sheehy Adrian, Gaete Pablo, Lillo Mauricio, Contreras Jorge
Final Pr. ID: MDP74
Authors: Munoz Camus Manuel, Quan Jonathan, Nguyen Thao, Nuno Janet, Sheehy Adrian, Gaete Pablo, Lillo Mauricio, Contreras Jorge
Keywords: Connexin, Adrenergic, Arrhythmias, Dystrophin, Ventricular arrhythmia
09 : 15 AM
Time-Course Single-Cell RNA Sequencing of Patient iPSC-Derived Heart Tissue Reveals Disease-Driving Pathways in Duchenne Muscular Dystrophy–Related Cardiomyopathy
Inazuka Fumika, Funakoshi Shunsuke, Hata Reo, Fujiwara Yuya, Ida Kazumi, Sakurai Hidetoshi, Yoshida Yoshinori
Final Pr. ID: MP1110
Authors: Inazuka Fumika, Funakoshi Shunsuke, Hata Reo, Fujiwara Yuya, Ida Kazumi, Sakurai Hidetoshi, Yoshida Yoshinori
Keywords: Dystrophin, Cardiomyopathy, Tissue engineering, Transcriptomics, Pathology
11 : 30 AM
Variant Burden and Severity of Cardiac Phenotype in Duchenne Muscular Dystrophy Cardiomyopathy
Geddes Gabrielle, Ware Stephanie, Schwantes-an Tae-hwi, Abreu Marco, Parent John, Howell Jennifer, Earl Conner, Soslow Jonathan, Markham Larry
Final Pr. ID: Su2012
Authors: Geddes Gabrielle, Ware Stephanie, Schwantes-an Tae-hwi, Abreu Marco, Parent John, Howell Jennifer, Earl Conner, Soslow Jonathan, Markham Larry
Keywords: Dystrophin, Cardiomyopathy, Genetics