Abstract Body (Do not enter title and authors here): Background: Angina Pectoris is a potentially life-threatening cardiovascular condition associated with significant morbidity, and mortality in adults aged >65 years. We assessed trends in Angina Pectoris-related mortality in the United States from 1999 to 2023 among adults to determine differences by sex, race, urbanization, and census region using CDC WONDER data.
Objective: We hypothesize that there are disparities in mortalities due to Angina Pectoris among adults in the United States of America (USA) based on age, gender, race, and census region.
Methods: We analyzed adults aged >65 years death certificates from the CDC-WONDER database with Angina Pectoris (ICD-10 code: I20) from 1999-2023. Age-adjusted mortality rates (AAMR) per 100,000 population were stratified by gender, race, census region, and year. Join-Point analysis was performed to estimate annual percent change (APC) and average annual percent change (AAPC) in mortality trends.
Results: Between 1999 and 2023, Angina Pectoris caused 36,544 deaths in adults aged >65 years. The AAMR first decreased sharply from 7.52 in 1999 to 2.02 in 2009 (APC: -13.48, 95% CI: -14.73 to –12.22), decreased to 1.71 in 2014 (APC: -0.42; 95% CI: -7.93 to 7.70), further increased to 4.38 in 2021 (APC: 2.00; 95% CI: 1.07-3.97 ), and finally decreased to 3.73 until 2023 (APC: -8.24; 95% CI: -21.65 to 7.47) with an overall AAPC (-3.18; 95% CI: -5.26 to –1.05). From 1999 to 2023, AAMR for males (8.22-4.75) was higher than that of females (6.95-3.02). From 1999 to 2023, Non-Hispanic (NH) White displayed the highest AAMR (7.75-3.86), followed by NH Black or African American (5.89-3.12), Hispanic or Latino (4.75-3.73), and NH Asian or Pacific Islander (3.17-2.53). West region showed highest AAPC (-0.48), followed by South (-3.08), Midwest (-4.27), and Northeast (-5.24). Rural areas exhibited higher overall AAMR (4.37) than urban areas (3.02).
Conclusion: Angina Pectoris-related mortality has increased, with highest rates among males, White individuals, and those in Western and rural U.S., requiring targeted, equitable public health strategies.