Abstract Body (Do not enter title and authors here): Introduction:The role of the right ventricle (RV) in influencing clinical outcomes and overall survival is well established. However,RV serial change over time and the influence of sociodemographic and clinical factors on RV structure/function remains understudied, especially among Hispanics/Latinos.

Methods:ECHO-SOL comprehensively assessed RV structure and function in Hispanic/Latino 1643 adults at baseline (visit 1 2011-2014) and 4.3 years later (visit 2 2015-2019). RV functional parameters included were RV peak S’ velocity (PsV), fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE); structural parameters: RV systolic (RVSA) and diastolic (RVDA) area; and hemodynamic parameters: maximal tricuspid pressure gradient (TR max PG), velocity time integral (VTI). Regression models were employed to assess the association of sociodemographic factors with RV structure/function at baseline. Marginal models were used to estimate RV change between visits. All analyses were weighted to account for complex survey design.

Results:At baseline, 41.5% were female, mean age 56.38±0.39 years. Increasing age was associated with worse RV systolic function, evidenced by functional parameters (lower TAPSE, S’ velocity) but lower RVDA. Females had worse RV structure/function (greater RVDA and decreased FAC) but better RV longitudinal shortening (greater TAPSE, PsV). Higher BMI was related to worse RV functional (decreased FAC) and structural parameters (greater RVDA). Higher income (>75K) correlated with better RV longitudinal shortening (PsV). First generation immigrants had worse RV structure with higher RVDA. (Table 1a) RV structure and function worsened over time (Table 1b), as evidenced by an change in all parameters: increased RV size (greater RVSA, RVDA), impaired systolic function (lower FAC) and longitudinal shortening (lower TAPSE,PsV), along with impaired stroke volume (lower TR max PG,VTI).

Conclusion: Among Hispanic/Latinos, different sociodemographic and clinical factors were associated with RV morphology and function. Overall, RV structure and function worsened over time, suggesting that sociodemographic factors may play an important role in the decline of RV parameters in this population.