Abstract Body: Background: Non-Rheumatic Valvular Heart Disease (NRVHD) is the 5^th leading cause of death amongst all cardiovascular disease in organization for economic cooperation and development (OECD) countries.

Method: Using GBD 2021 meta-tool, we estimated incidence, prevalence, deaths, disability-adjusted life years (DALYs) due to NRVHD by age, sex, year and location across the 38 OECD countries from 1990-2021.

Result: From 1990-2021, the average annual percentage change (AAPC) in the age-standardized incidence rate (ASIR) per 100,000 rose by 55%, and prevalence rate (ASPR) increased by 54%. Conversely, the mortality rate (ASMR) fell by 45%, and DALYs rate (ASDALR) decreased by 87%. Nationally, from 1990-2021, the highest AAPC in ASIR observed in Estonia increasing by 2.43% and Portugal by 2.25%, while the US saw a more modest rise of 0.5%. The ASMR increased most notably in Poland by 5.51%, followed by Lithuania at 4.57%, Czechia at 4.39%, and Latvia at 4.115%. In terms of the ASDALR, Poland experienced a 4.41% increase, Lithuania 3.18%, and Latvia 3.08%. From 1990-2021, ASIR rose by 47% for males and 58% for females; ASMR decreased by 43% and 48%, respectively; ASDALR fell by 82% for and 90% respectively, indicating a more pronounced decline in female disease burden.

Conclusion: There was a significant increase in the incidence and prevalence rates of NRVHD, indicating growing healthcare challenges. However, reductions in mortality and DALY rates suggest improvements in medical treatments and prevention strategies.