Logo

American Heart Association

  151
  0


Final ID: 074

Interplays of ADH1B Genotype, Alcohol Consumption, and Gut Microbiota in Relation to Insulin Resistance

Abstract Body: Background: Alcohol consumption has been linked to alterations in gut microbiota and insulin resistance. The alcohol dehydrogenase 1B (ADH1B) gene plays a crucial role in alcohol catabolism, where rs1229984 variant carriers (CT/TT) catabolize ethanol at an 80-fold faster rate than non-carriers (CC).
Methods: We analyzed fecal metagenomic sequencing data from diabetes-free participants in the Hispanic Community Health Study/Study of Latinos. We used ANCOMBC to identify gut microbiota associated with alcohol consumption in non-carriers (n=1,399) and carriers (n=193). We constructed genotype-specific gut microbiome scores (GMSs) based on identified species associated with alcohol consumption to examine how microbiota may influence the relationship between alcohol consumption and insulin resistance in non-carriers and carriers. Insulin resistance was defined as HOMA-IR > 2.5.
Results: Higher alcohol consumption was associated with lower odds of insulin resistance in non-carriers. Distinct microbial species associated with alcohol consumption were identified in non-carriers (54 species) and carriers (16 species) (Fig A). In non-carriers, the genotype-specific GMS modified the relationship between alcohol consumption and insulin resistance (Pinteraction=0.011). The odds ratios (OR) for insulin resistance with increasing alcohol consumption levels across low, moderate, and high tertiles of GMS were 0.75 (95%CI 0.58-0.96), 0.82 (0.67-1), and 1.13 (0.93-1.39), respectively (Fig B). We identified that abundance of individual alcohol-related species in non-carriers, such as Prevotella copri (enriched with alcohol consumption), Ruminococcus callidus (enriched), and Erysipelatoclostridium ramosum (depleted), modified the relationship between alcohol consumption and insulin resistance in non-carriers (Fig C).
Conclusions: Our findings suggest a potential role of gut microbiota in the protective association between alcohol consumption and insulin resistance in ADH1B variant non-carriers.
  • Wang, Brian  ( Albert Einstein College of Medicine , Brooklyn , New York , United States )
  • Peters-samuelson, Brandilyn  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Luo, Kai  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Li, Yang  ( Albert Einstein College of Medicine , Brooklyn , New York , United States )
  • Cordero, Christina  ( University of Miami , Coral Gables , Florida , United States )
  • Perreira, Krista  ( University of North Carolina School , Chapel Hill , North Carolina , United States )
  • Pirzada, Amber  ( University of Illinois Chicago , Chicago , Illinois , United States )
  • Daviglus, Martha  ( UNIVERSITY ILLINOIS CHICAGO , Chicago , Illinois , United States )
  • Kaplan, Robert  ( Albert Einstein College of Medicine , Brooklyn , New York , United States )
  • Burk, Robert  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Qi, Qibin  ( ALBERT EINSTEIN COLLEGE OF MEDICINE , Bronx , New York , United States )
  • Author Disclosures:
    Brian Wang: DO NOT have relevant financial relationships | Robert Burk: No Answer | Qibin Qi: DO NOT have relevant financial relationships | Brandilyn Peters-Samuelson: DO NOT have relevant financial relationships | Kai Luo: DO NOT have relevant financial relationships | Yang Li: No Answer | Christina Cordero: No Answer | krista perreira: No Answer | Amber Pirzada: DO NOT have relevant financial relationships | Martha Daviglus: DO NOT have relevant financial relationships | Robert Kaplan: No Answer
Meeting Info:
Session Info:

11.B Diabetes

Sunday, 03/09/2025 , 01:30PM - 03:00PM

Oral Abstract Session

More abstracts on this topic:
A CRISPR-Activation CROP-seq Screen Identifies HMGN1 as a Dosage-Sensitive Regulator of Heart Defects in Down Syndrome

Ranade Sanjeev, Mital Rahul, Boileau Ryan, Koback Frances, Padmanabhan Arun, Merriman Alexander, Wallace Langley, Nguyen Annie, Poulis Nikolaus, Gifford Casey, Pollard Katherine, Li Feiya, Srivastava Deepak, Whalen Sean, Angelo Pelonero, Ye Lin, Huang Yu, Brand Abigail, Nishino Tomohiro, Costa Mauro

Angiotensin Converting Enzyme Gene Polymorphisms (ACE-I/D) Do Not Predict Exercise-Induced Cardiac Remodeling or Performance in Adolescent Male Athletes

Becker Kristian, Hardie William, Gubanich Paul, Hill Garick, Logan Kelsey, Martin Lisa, Powell Adam

More abstracts from these authors:
ABO Blood Type Modifies the Association Between Fiber Intake and Incident Cardiovascular Disease: The Role of Gut Microbiota and Circulating Metabolites

Jia Chengyong, Peters-samuelson Brandilyn, Yu Bing, Usyk Mykhaylo, Daviglus Martha, Burk Robert, Kaplan Robert, Qi Qibin

Gut microbiome, blood metabolome and incident hypertension in Hispanic Community Health Study/Study of Latinos

Luo Kai, Peters-samuelson Brandilyn, Daviglus Martha, Thyagarajan Bharat, Yu Bing, Burk Robert, Knight Rob, Kaplan Robert, Qi Qibin

You have to be authorized to contact abstract author. Please, Login
Not Available