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American Heart Association

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Final ID: 4368556

Mechanical Circulatory Support Device Related Complications in Contemporary North American Cardiac Intensive Care Units

Abstract Body (Do not enter title and authors here): Background: The use of temporary mechanical circulatory support (tMCS) devices in cardiogenic shock has sharply risen; however, there are limited data depicting the current rates of device related complications and associated downstream clinical ramifications.

Methods: The Critical Care Cardiology Trials Network is an international multicenter research network of advanced cardiac intensive care units (CICUs). Between 2017-2024 participating CICUs captured all consecutive admissions with cardiogenic shock during annual minimum 2-month collection periods. This analysis focused on cases managed with non-ECMO tMCS. We conducted Wilcoxon rank-sum tests for continuous variables, chi-squared test for categorical variables, and a multi-variable linear mixed-effect regression model.

Results: Among 2,015 admissions with cardiogenic shock and tMCS, 103 (5.1%) developed an MCS-related complication with substantial variation across device types (2.8% to 10.9%, Fig A). Limb ischemia (28.9%) and access site bleeding (22.9%) were the most common tMCS-related complications. Admissions with a tMCS related complication were slightly younger (61 v. 63 years) and more likely female (34% v. 27%). Cases with tMCS-related complications had higher shock severity reflected by more SCAI D shock (43.7% versus 35.1%) and number of vasoactive medications (3 v. 2). Admissions with an MCS complication had higher rates of mechanical ventilation (68.9% v. 59.1%) and renal replacement therapy (33.0% v. 17.6%) with longer ICU length of stay (9.2 v. 6.6 days). In-hospital mortality was higher among cases with complications (46.6% v. 31.6%; Fig B); complications were associated with a higher mortality even after adjustment (OR 1.63; 95% CI: 1.00 – 2.67; p = 0.05).

Conclusions: The rates of MCS related complications vary notably by access site and specific modality; complications were associated with longer ICU stays and high mortality rates.
  • Kochar, Ajar  ( Brigham and Womens Hospital , Chestnut Hill , Massachusetts , United States )
  • Park, Jeong-gun  ( Brigham and Women's Hospital , Boston , Massachusetts , United States )
  • Berg, David  ( Brigham and Womens Hospital , Boston , Massachusetts , United States )
  • Patel, Siddharth  ( Brigham and Womens Hospital , Boston , Massachusetts , United States )
  • Bohula, Erin  ( Brigham and Womens Hospital , Chestnut Hill , Massachusetts , United States )
  • Morrow, David  ( Brigham and Womens Hospital , Boston , Massachusetts , United States )
  • Author Disclosures:
    Ajar Kochar: DO have relevant financial relationships ; Consultant:Faraday Pharmaceuticals:Active (exists now) ; Researcher:Shockwave Inc:Active (exists now) ; Consultant:Abiomed:Past (completed) | Jeong-Gun Park: DO NOT have relevant financial relationships | David Berg: DO have relevant financial relationships ; Research Funding (PI or named investigator):AstraZenea:Active (exists now) ; Other (please indicate in the box next to the company name):CEC - CeleCor Therapeutics:Active (exists now) ; Other (please indicate in the box next to the company name):CEC - Beckman Coulter:Active (exists now) ; Other (please indicate in the box next to the company name):CEC - Novo Nordisk:Active (exists now) ; Other (please indicate in the box next to the company name):CEC - Tosoh Biosciences:Active (exists now) ; Other (please indicate in the box next to the company name):CEC - Kowa Pharmaceuticals:Past (completed) ; Speaker:USV Private Limited:Past (completed) ; Speaker:Pri-Med:Past (completed) ; Speaker:Metabolic Endocrine Education Foundation:Past (completed) ; Consultant:Youngene Therapeutics:Past (completed) ; Consultant:Pfizer:Active (exists now) ; Consultant:AstraZeneca:Active (exists now) ; Research Funding (PI or named investigator):Merck:Active (exists now) ; Research Funding (PI or named investigator):Pfizer:Active (exists now) | Siddharth Patel: DO have relevant financial relationships ; Consultant:Janssen:Active (exists now) | Erin Bohula: No Answer | David Morrow: DO have relevant financial relationships ; Research Funding (PI or named investigator):Abbott:Active (exists now) ; Consultant:Roche:Active (exists now) ; Consultant:Regeneron:Active (exists now) ; Consultant:Merck & Co:Active (exists now) ; Consultant:Abbott:Past (completed) ; Research Funding (PI or named investigator):Roche:Active (exists now) ; Research Funding (PI or named investigator):Pfizer:Active (exists now) ; Research Funding (PI or named investigator):Novartis:Active (exists now) ; Research Funding (PI or named investigator):Merck & Co:Active (exists now) ; Research Funding (PI or named investigator):4TEEN4:Active (exists now) ; Research Funding (PI or named investigator):Daiichi-Sankyo:Active (exists now) ; Research Funding (PI or named investigator):AstraZeneca:Active (exists now) ; Research Funding (PI or named investigator):Anthos Therapeutics:Active (exists now) ; Research Funding (PI or named investigator):Amgen:Active (exists now) ; Research Funding (PI or named investigator):Abiomed:Active (exists now)
Meeting Info:

Scientific Sessions 2025

2025

New Orleans, Louisiana

Session Info:

Dickinson W. Richards Memorial Lecture

Monday, 11/10/2025 , 09:45AM - 11:00AM

Abstract Oral Session

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