Scientific Sessions 2025  /  Advances in VT: Cutting-Edge Therapies, Techniques, and Risk Management  /  Catheter Ablation versus Antiarrhythmic Drugs for Ventricular Tachycardia: A Systematic Review and Meta-Analysis
Logo

American Heart Association

  68
  0

Final ID: MP1574

Catheter Ablation versus Antiarrhythmic Drugs for Ventricular Tachycardia: A Systematic Review and Meta-Analysis

Abstract Body (Do not enter title and authors here): Background: Sustained ventricular tachycardia (VT) and fibrillation-related sudden cardiac death (SCD) account for nearly 450,000 deaths annually in the United States. Catheter ablation (CA) and antiarrhythmic drugs (AADs) are commonly used to manage VT recurrence; however, their comparative efficacy and safety remain uncertain.

Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing CA and AADs in patients with ischemic cardiomyopathy and implantable cardioverter-defibrillators (ICDs). PubMed, Embase, and Cochrane CENTRAL Library were searched up to February 15, 2025. Primary outcomes included all-cause mortality, cardiovascular mortality, VT storm, and appropriate ICD shock. Secondary outcomes included inappropriate ICD shock, appropriate antitachycardia pacing (ATP), heart failure hospitalization, stroke/transient ischemic attack (TIA), and myocardial infarction (MI). Risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using a random-effects model.

Results: Three RCTs encompassing 587 patients (287 CA, 300 AADs) were included. No significant differences were found between CA and AADs in all-cause mortality (RR 0.88, 95% CI: 0.63–1.22; p=0.43), cardiovascular mortality (RR 1.23, 95% CI: 0.77–1.98; p=0.39), VT storm (RR 0.76, 95% CI: 0.39–1.46; p=0.41), or appropriate ICD shock (RR 0.87, 95% CI: 0.69–1.10; p=0.24). Secondary outcomes, including inappropriate ICD shock, ATP, heart failure hospitalization, stroke/TIA, and MI, were also comparable between the two groups.

Conclusions: CA and AADs demonstrated comparable efficacy and safety in patients with VT. Larger high-quality trials are warranted to confirm these findings and further define the role of CA as a potential first-line therapy.
  • Patel, Palak  ( New York Medical College , Newark , New Jersey , United States )
  • Shahid, Sufyan  ( Khawaja Muhammad Safdar Medical College , Sialkot , Punjab , Pakistan )
  • Tabassum, Shehroze  ( The Wright Center for GME , Scranton , Pennsylvania , United States )
  • Ali, Muhammad Abdullah  ( Khyber Medical College, Peshawar , Peshawar , Pakistan )
  • Alam, Umama  ( Khyber Medical College, Peshawar , Peshawar , Pakistan )
  • Ejaz, Zoya  ( Allama Iqbal Medical College , Lahore , Pakistan )
  • Iqbal, Minahil  ( Allama Iqbal Medical College , Lahore , Pakistan )
  • Jain, Hritvik  ( AIIMS Jodhpur , Jodhpur , India )
  • Khalid, Salman  ( Oklahoma Heart Hospital , Oklahoma , Oklahoma , United States )
    • Author Disclosures:
    Palak Patel: DO NOT have relevant financial relationships | Sufyan Shahid: DO NOT have relevant financial relationships | Shehroze Tabassum: DO NOT have relevant financial relationships | Muhammad Abdullah Ali: DO NOT have relevant financial relationships | Umama Alam: No Answer | Zoya Ejaz: No Answer | Minahil Iqbal: DO NOT have relevant financial relationships | Hritvik Jain: DO NOT have relevant financial relationships | Salman Khalid: No Answer
Meeting Info:

Scientific Sessions 2025

2025

New Orleans, Louisiana

Session Info:

Advances in VT: Cutting-Edge Therapies, Techniques, and Risk Management

Sunday, 11/09/2025 , 11:50AM - 01:05PM

Moderated Digital Poster Session

More abstracts on this topic:
Catheter Ablation Outperforms Medical Therapy in Management of Persistent Atrial Fibrillation: Enhanced Cardiac Function, Reduced Mortality, and Lower Hospitalizationion Rates

Sharma Anubhuti, Panjiyar Binay, Sharma Arundhati, Daid Simranpreet Singh, Senthil Velmurugan Isha, Seelam Laxmi Priya, Aryal Saurav, Sanghvi Urja, Dantuluri Sahitya, Syed Saif

A Beta Tubulin Mutation Suppresses Arrhythmias and Improves Connexin 43 Localization in Heart of Duchenne Muscular Dystrophy Mice

Zhou Delong, Liu Tong, Yehia Ghassan, Romanienko Peter, Rodney George, Wehrens Xander, Lampe Paul, Gourdie Robert, Xie Lai-hua, Fraidenraich Diego, Nouet Julie, Mesa Elam, Yegneshwaran Vasisht, Geukgeuzian Geovanni, Adibemma Ifeanyichukwu, Nandakumar Swetha, Ramirez Edwin, Li Hong

More abstracts from these authors:
Efficacy and Safety of Sedative Hypnotic Induction Agents on Perioperative Outcomes in Coronary Artery Bypass Grafting: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

Rasool Muhammad Mujtaba, Cheema Shamikha, Murtaza Muhammad, Kamran Haneen, . Abdullah, Khan Misha, Majeed Uzair, Raza Muhammad Ahmed, Zaeem Muhammad, Ali Muhammad Abdullah, Alam Umama

Diagnostic accuracy of Apple Watch Electrocardiogram for Atrial Fibrillation: A Systematic Review and Meta-Analysis

Shahid Sufyan, Iqbal Minahil, Saeed Humza, Hira Sara, Batool Amna, Goyal Aman

4366761_File000000.jpg
4366761_File000000.jpg
You have to be authorized to contact abstract author. Please, Login
Not Available