Abstract Body (Do not enter title and authors here): Background: Following an ischemic stroke, a serious complication known as hemorrhagic
transformation (HT) might jeopardize patient outcomes. Inflammatory indicators, such as the
neutrophil-to-leukocyte ratio (NRR), and lipid markers, such as the low-density lipoprotein
(LDL) to high-density lipoprotein (HDL) ratio, have been investigated as HT predictors. Recent
research has delved further into the predictive significance of these biomarkers for ischemic
stroke outcomes.
Objectives: To systematically review the literature on the predictive value of NLR and LDL to
HDL ratios for HT in ischemic stroke patients, incorporating recent findings that enhance our
understanding of these biomarkers.
Methods: A detailed search of electronic databases was conducted to gather studies focusing on
NLR and LDL to HDL ratios as predictors for HT in ischemic stroke. The selection process
followed strict inclusion criteria, and the quality of studies was rigorously assessed.
Results: The paper discusses new findings that emphasize the impact LDL and NLR play in
influencing HDL ratios and, hence, HT prediction. Following an ischemic stroke, an increased
incidence of HT, especially parenchymal hematoma (PH), has been associated with greater NLR.
A high neutrophil-to-HDL ratio (NHR) has also been identified as a possible predictor of poor
prognosis in ischemic stroke, underscoring its significance in predicting HT. Furthermore, the
LDL-to-HDL ratio has been connected to long-term clinical outcomes like death and recurrent
myocardial infarction, which may be associated with HT risk.
Conclusions: In individuals with ischemic stroke, NLR and LDL-to-HDL ratios are potential HT
indicators. The addition of current data underscores the potential of these ratios not just as HT
indicators but also as markers for broader stroke-related effects. More studies are needed to
validate these results and provide consistent recommendations for their use in clinical practice.