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American Heart Association

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Final ID: Su3028

Nationwide trends in Major Adverse Cardiac and Cardiovascular Events and ALL-cause Mortality in Cardiovascular-Kidney-Metabolic Syndrome Among Geriatric Patients.

Abstract Body (Do not enter title and authors here): BACKGROUND
The American Heart Association (AHA) has acknowledged the interconnection of obesity, type 2 diabetes mellitus (DM), cardiovascular disease (CVD), and chronic kidney disease (CKD) as a complex health disorder named Cardiovascular-Kidney-Metabolic (CKM) syndrome. Patients with CKM progress to major adverse cardiac and cerebrovascular Events (MACCE). The aim of the study is to analyse nationwide trends in MACE and all causes. mortality among patients aged 65 years and older with CKM syndrome.
METHODS
Using a National Inpatient Sample (2016–2020) geriatric admissions among patients admitted with CKD and at least One cardiometabolic risk factor (HTN, DM, HLD, and obesity) were selected using ICD-10. codes. Patients were classified into MACCE+ve cohorts if they had acute myocardial infarction, cardiac arrest or acute ischaemic stroke present otherwise into MACCE-ve. Trends, Demographics, comorbidities, and all-cause mortality were analysed between the two cohorts.
RESULTS
In our NIS study, the MACCE+ve and -ve cohorts had median ages of 78 (72–85) and 78 (72–85). years with 55.9% and 51.1% males and 44.1%. and 48.9% females, respectively. over a period of 5 years (2016–2020) in patients with CKM syndrome hospitalisation has increased with MACCE (from 10.4% to 12.7%) with an increase in hospital mortality (4.6% to 6%) (ptrend<0.001). In our analysis, patients with CKM admitted to MACCE had statistically significant all-cause mortality (15.3% vs. 3.4%), total length of stay (5 vs. 4), and hospital cost ($66,824 vs. $43,727) compared to MACCE-ve cohorts (p-value < 0.001).
CONCLUSION
Our analysis suggests alarmingly rising trends in MACCE in CKM syndrome, which significantly impacts in-hospital outcomes. We need to conduct more studies to enhance our comprehension of managing CKM syndrome.
  • Prajapati, Kesar  ( Metropolitan Hospital Center , New York , New York , United States )
  • Doshi, Kesha  ( B.J.Medical College , Ahmedabad , Gujarat , India )
  • Doshi, Preet  ( SUNY Upstate Medical University , Syracuse , New York , United States )
  • Pasnoor, Diksha Sanjana  ( Kamineni Academy of Medical Sciences and Research Centre,Hyderabad , Hyderabad , India )
  • Brereton, Brian  ( Dorset County Hospital , Dorchester , United Kingdom )
  • Mettela, Sambasiva Rao  ( Katuri Medical College & Hospital , Guntur , India )
  • Kalapala, Chaitanya  ( Katuri Medical College & Hospital , Guntur , India )
  • Cheruvu, Naga Pratyusha  ( Gandhi Medical College , Saint augustine , Florida , United States )
  • Desai, Rupak  ( Independent Researcher , Atlanta , Georgia , United States )
  • Author Disclosures:
    Kesar Prajapati: DO NOT have relevant financial relationships | Kesha Doshi: No Answer | Preet Doshi: No Answer | Diksha Sanjana Pasnoor: DO NOT have relevant financial relationships | Brian Brereton: DO NOT have relevant financial relationships | Sambasiva Rao Mettela: DO NOT have relevant financial relationships | CHAITANYA KALAPALA: DO NOT have relevant financial relationships | Naga Pratyusha Cheruvu: DO NOT have relevant financial relationships | Rupak Desai: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Translating the Concept of CKM Syndrome to Real-World Populations

Sunday, 11/17/2024 , 03:15PM - 04:15PM

Abstract Poster Session

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