Abstract Body (Do not enter title and authors here): Introduction: Stroke is among the leading global health burdens worldwide due to the
resultant morbidity and mortality. Accordingly, thorough evaluation of the temporal
trends in stroke-related mortality in Canada is mandatory to effectively tackle the
associated global and socioeconomic burden.

Research question: Are there temporal trends in stroke-related mortality in Canada
during the last 3 decades?

Aim: To evaluate the temporal trends in stroke-related mortality in Canada over the past
3 decades.

Methods: Mortality trends of stroke in Canada have been evaluated by initially retrieving
data from Global Burden of Diseases 2019 database. JoinPoint Analysis software was
utilized to calculate the Annual Percentage Change (APC) and the Average Annual
Percentage Change (AAPC).
Results: There was a total of 1,269,854 stroke-related death reported during the period
of 1990-2019. There is an overall decline in stroke-related death, with females
displaying a higher decline in mortality from 1990 to 2019 with AAPC of -1.00 (95%CI: -
1.04 to -0.96; p<0.001) than males (AAPC -0.68 95%CI: -0.73 to -0.62; p<0.001).
Additionally. There is a declining mortality among all age groups, most significantly in
the group of 50-74 years of age (AAPC -1.23, 95%CI: -1.31 to -1.15; p<0.001) followed
by the 75 years and older age group (AAPC -1.20, 95%CI: -1.27 to -1.12; p<0.001),
while the group of the 15-49 year old had the smallest decrease in mortality (AAPC -
0.97, 95%CI: -1.16 to -0.72; p<0.001).

Conclusion: A noticeable decline in the stroke-related mortality across both genders and
all age groups in Canada has been demonstrated across the past 30 years.
Comparison of these trends with other international and global trends is warranted to
identify the factors associated with this decline.