Abstract Body (Do not enter title and authors here): Introduction: Cardiovascular disease (CVD) and cancer are among the leading causes of morbidity and mortality worldwide. Increasing evidence suggests that sociodemographic factors such as race, ethnicity, income, education, and stress levels significantly influence the prevalence and outcomes of these diseases. The All of Us Research Program provides a unique opportunity to explore these disparities across a diverse U.S. population. This study aims to examine how sociodemographic disparities are associated with stress, CVD, and cancer outcomes. We hypothesize that higher perceived stress levels, lower income, lower education levels, and minority race/ethnicity groups are associated with higher incidences of CVD and cancer.

Methods: Data from 55,505 All of Us Research program participants were analyzed. Key variables included age, race, ethnicity, education, household income, perceived stress level, and history of CVD and cancer. Descriptive statistics were used to summarize participant demographics. Multivariate logistic regression models were employed to examine the associations between sociodemographic factors and the outcomes of interest (CVD and cancer).

Results: Older participants had a higher prevalence of both CVD (mean age: 60.8 vs. 50.5, p < 0.001) and cancer (mean age: 63.6 vs. 51.7, p < 0.001). Black/African Americans had a higher incidence of CVD (21.3% vs. 78.7%, p < 0.001), while Whites had a higher prevalence of cancer (5.3% vs. 94.7%, p < 0.001). Lower income and higher stress levels were also associated with higher CVD incidence (<$25k: 20.1% vs. 79.9%, p < 0.001; high stress: 15.0% vs. 85.0%, p < 0.001). Multivariate logistic regression showed significant predictors for CVD, including age (OR = 1.05), Black race (adjusted OR = 1.18), and high stress (adjusted OR = 1.27). For cancer, significant predictors were age (OR = 1.06), Hispanic ethnicity (OR = 0.53), and moderate stress (adjusted OR = 1.12).

Conclusion: The study highlights significant sociodemographic disparities in the incidence of CVD and cancer. Older age, Black/African American race, lower income, and higher perceived stress levels were associated with higher odds of CVD. For cancer, older age, White race, and higher income were significant predictors. Perceived stress level plays a crucial role in mediating these associations, underscoring the need for targeted interventions to address these disparities in high-risk populations.