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American Heart Association

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Final ID: Sa4143

Direct Oral Anticoagulants vs Vitamin K Antagonists for Cardiovascular Interventions: A Systematic Review and Meta-Analysis

Abstract Body (Do not enter title and authors here): Introduction: Anticoagulation therapy is crucial in enhancing perioperative outcomes, yet uncertainty persists regarding the optimal use of Direct Oral Anticoagulants (DOACs) and Vitamin K Antagonists (VKAs) in cardiovascular interventions. Key outcomes such as bleeding, thromboembolic events, and mortality are critical. Conducting a thorough review is essential to make well-informed decisions that improve patient quality of life and mitigate complications.
Hypothesis: This meta-analysis aimed to investigate whether Direct Oral Anticoagulants (DOACs) reduce perioperative complications such as bleeding, thromboembolic events, and mortality compared to Vitamin K Antagonists (VKAs) in patients undergoing cardiovascular procedures.
Methods: The present study was conducted in accordance with PRISMA guidelines. A systematic search was conducted in PubMed, MEDLINE, Scopus, Web of Science, Cochrane, and EMBASE databases on 05/14/2024. Data extraction was rigorously performed, and a random-effects model was used for data synthesis.
Results: The review included 25 studies involving a total of 25,754 patients. For bleeding risk, the meta-analysis showed that DOACs are associated with a lower risk compared to VKAs, with a relative risk (RR) of 0.69 (95% CI: 0.51 to 0.94, p = 0.0457, I2 = 60%). Thromboembolic events showed no significant difference between DOACs and VKAs (RR: 1.13, 95% CI: 0.74 to 1.73, p = 0.5313, I2 = 15%). Mortality outcomes also showed no significant difference (RR: 0.53, 95% CI: 0.20 to 1.43, p = 0.1622, I2 = 68%).
Conclusion: The systematic review and meta-analysis demonstrate that DOACs are associated with a lower risk of bleeding compared to VKAs, with no significant difference in thromboembolic events and mortality. This evidence supports the substantial benefit of DOACs in cardiovascular interventions. Further research is needed to consolidate these findings and improve patient outcomes. PROSPERO registry— CRD42024547465
  • Calderon Martinez, Ernesto  ( The University of Texas Science Medical Center at Houston , Houston , Texas , United States )
  • Navarrete Gutierrez, Gabriela  ( Universidad de Buenos Aires Facultad de Medicina , Buenos Aires , Argentina )
  • Afreen, Sabia  ( Shanghai Medical College , Shangai , China )
  • Arruarana, Victor  ( Brookdale University Hospital and Medical Center , Brooklyn , New York , United States )
  • Salazar Ore, Jonathan Victor  ( Universidad de Buenos Aires , Buenos Aires , Argentina )
  • Miret Durazo, Carla Isabella  ( Centro de Estudios Universitarios Xochicalco , Tijuana , Mexico )
  • Zuniga Gonzalez, Noe Alejandro  ( Universidad Juárez del Estado de Durango , Durango , Mexico )
  • Zurita Salas, Yuriana  ( Universidad Juárez Autónoma de Tabasco , Tabasco , Mexico )
  • Navarro, Evelyn  ( Universidad Autónoma de Guadalajara , Guadalajara , Mexico )
  • Betances, Clara  ( Universidad Tecnológica de Santiago , Santiago , Dominican Republic )
  • Garcia Rodriguez, Ernesto Enrique  ( Brookdale University Hospital and Medical Center , Brooklyn , New York , United States )
  • Floridia, Lautaro  ( Universidad Nacional del Litoral , Santa fe , Argentina )
  • Author Disclosures:
    Ernesto Calderon Martinez : DO NOT have relevant financial relationships | Gabriela Navarrete Gutierrez: No Answer | Sabia Afreen: No Answer | Victor Arruarana: DO NOT have relevant financial relationships | Jonathan Victor Salazar Ore: No Answer | Carla Isabella Miret Durazo: No Answer | Noe Alejandro Zuniga Gonzalez: DO NOT have relevant financial relationships | Yuriana Zurita Salas: No Answer | Evelyn Navarro: DO NOT have relevant financial relationships | Clara Betances: DO NOT have relevant financial relationships | Ernesto Enrique Garcia Rodriguez: DO NOT have relevant financial relationships | Lautaro Floridia: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Perioperative Interventions in Cardiac Surgery: From Predictive Models to Pain Management

Saturday, 11/16/2024 , 10:30AM - 11:30AM

Abstract Poster Session

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