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American Heart Association

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Final ID: Su4067

Incidence and Outcomes of Acute Myocardial Infarction (AMI) in Hematological Malignancy Patients: Systematic review and Meta-analysis

Abstract Body (Do not enter title and authors here):
Background
Patients with hematological malignancies may face increased cardiovascular risks, including acute myocardial infarction (AMI). This systematic review and meta-analysis aims to evaluate the incidence and outcomes of AMI in patients with hematological malignancies compared with the general population.

Methods
A comprehensive literature search was conducted using the PubMed, Embase, and Google Scholar databases. Random effect models were utilized to calculate Mantel-Haenszel odds ratios (ORs) with 95% confidence intervals (CIs). The inverse variance method with DerSimonian–Laird (DL) of Tau2 was used to calculate standardized mean differences (SMDs) with CIs. Statistical significance was set at p < 0.05. The primary endpoint was the incidence of AMI, while secondary outcomes included in-hospital mortality, length of hospital stay, likelihood of undergoing invasive procedures, total hospital costs, bleeding events, and stroke outcomes.

Results
Twenty-six articles, including approximately 6.33 million patients with hematological malignancies, were included in the meta-analysis. Hematological malignancies were not associated with an increased incidence of AMI compared with the general population (OR = 0.91; 95% CI 0.80 to 1.03; p<0.001). AMI in hematological malignancies was associated with an increased risk of in-hospital mortality (OR = 1.71; 95% CI 1.57 to 1.86; p<0.001), bleeding event (OR = 1.30; 95% CI 1.12 to 1.60; p<0.001), and stroke (OR = 1.24; 95% CI 1.09 to 1.42) compared with AMI in the general population. Patients admitted due to AMI in hematologic malignancies also experienced an increased length of stay (SMD = 0.25; 95% CI 0.20 to 0.28; p<0.001) compared with AMI in the general population . There was no significant difference between the two groups in terms of the likelihood of undergoing invasive procedures (OR = 0.62; 95% CI 0.56 to 0.69) or total hospital expenditure (SMD = 0.09; 95% CI -0.01 to 0.19).

Conclusion
While hematological malignancies do not appear to increase the incidence of acute myocardial infarction (AMI), patients who experience AMI episodes are at higher odds of in-hospital complications.
  • Rathore, Sawai Singh  ( Dr. Sampurnanand Medical College , Jodhpur , India )
  • Farrukh, Ameer  ( University of Galway School of Medicine , Galway , Ireland )
  • Yao, Sem Josue Nsanh  ( Western Reserve Hospital , Cuyahoga falls , Ohio , United States )
  • Al Shyyab, Ibrahim  ( University of Sharjah , Sharjah , United Arab Emirates )
  • Vidaurre Corrales, Vanessa  ( Universidad Privada del Valle , Cochabamba , Bolivia, Plurinational State of )
  • Wint, Zario  ( All American Institute of Medical Sciences , Black River , Jamaica )
  • Jain, Hritvik  ( AIIMS Jodhpur , Jodhpur , India )
  • Goyal, Aman  ( Seth GSMC and KEM Hospital , Mumbai , India )
  • Kumar, Ashish  ( Cleveland Clinic Akron General , Akron , Ohio , United States )
  • Author Disclosures:
    Sawai Singh Rathore: DO NOT have relevant financial relationships | Ameer Farrukh: DO NOT have relevant financial relationships | Sem Josue Nsanh Yao: No Answer | Ibrahim Al Shyyab: DO NOT have relevant financial relationships | Vanessa Vidaurre Corrales: DO NOT have relevant financial relationships | Zario Wint: DO NOT have relevant financial relationships | Hritvik Jain: DO NOT have relevant financial relationships | Aman Goyal: DO NOT have relevant financial relationships | Ashish Kumar: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Open Your Heart To Me: The Role of Invasive Cardiovascular Procedures in the Cancer Patient

Sunday, 11/17/2024 , 11:30AM - 12:30PM

Abstract Poster Session

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