Abstract Body (Do not enter title and authors here):
Introduction: Non-ST elevation myocardial infarction (NSTEMI) significantly contributes to the burden of cardiovascular diseases, affecting millions of patients. The management of NSTEMI has evolved and it involves invasive and conservative strategies, the optimal management remains unclear. We conducted this systematic review and meta-analysis to compare the two different strategies and their long-term outcomes.

Methods: We systematically examined the clinical outcomes of conservative and invasive management of patients with NSTEMI using medical records from Web of Science, PUBMED, Scopus, and Cochrane. Our outcomes of interest were all-cause mortality, myocardial infarction (MI), and major bleeding. Odds Ratios (OR) and 95% CI were used in a fixed-effect model to analyze the data.

Results: Our study included 24 studies with a total of 1,076,572 patients. the invasive strategy was significantly associated with a reduction in all-cause mortality (OR: 0.52, 95% CI: 0.51 to 0.53), and the incidence of myocardial infarction (OR: 0.84, 95% CI: 0.73 to 0.97). However, the invasive strategy showed a significant increase in major bleeding events (OR: 1.93, 95% CI: 1.87 to 1.98).

Conclusion: The invasive strategy showed better clinical outcomes on the long-term follow-up related to all-cause mortality and myocardial infarction, with an increase in the incidence of major bleeding events.