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American Heart Association

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Final ID: Mo2150

The effectiveness of coronary sinus reducer in refractory angina: A meta-analysis of 18 studies

Abstract Body (Do not enter title and authors here): Introduction: Despite the continuous development of the medical therapeutic revolution, there are many conditions that pose a great challenge and are still spreading at increasing rates, such as refractory angina (RA), which is considered a burden on patients and on the health systems. However, with the emergence of effective treatment options such as a coronary sinus reducer (CSR) that works to narrow the coronary sinus in controlled manner aiming to restore efficient blood flow and reduce symptoms.
Purpose: We aimed to study the effectiveness of CSR in patients with refractory angina (RA), and give a comprehensive appraisal from the published records.
Methods: A comprehensive search was done on PubMed, Cochrane Library, Scopus, and WOS until Feb 2024. We included studies that assessed the effectiveness of CSR in patients with RA. Clinical improvement, implantation success, periprocedural complications, revascularization, 6MWT distance and change in SAQ score were our outcomes of interest.
Results: 18 studies comprising 1149 patients were included in the analysis. The pooled implantation success was 98% (95% CI: 97% to 99%), clinical improvement > 1 class was 63% (95% CI: 52% to 72%), and clinical improvement > 2 class was 37% (95% CI: 32% to 41%). The incidence rate of periprocedural complications and PCI was reported as follows, respectively (OR: 0.05, 95% CI: 0.03 to 0.08, and 0.37, 95% CI: 0.18 to 0.61). Moreover, the incidence rate of all-cause mortality was low (OR: 0.06, 95% CI: 0.03 to 0.11). Regarding physical activity and quality of life, CSR improved 6MWT distance (MD = 323.82, 95% CI: 273.52 to 372.13), and all categories of SAQ score either angina frequency, angina stability, physical limitation, quality of life, or treatment satisfaction.
Conclusion: Coronary Sinus Reducer is a promising treatment for the management of refractory angina, as it showed clinical improvement with higher implantation success. It also improved the physical activity and quality of life scores. Large-volume RCTs are warranted to test the efficacy of CSR in a long-term manner.
  • Gadelmawla, Ahmed Farid  ( Faculty of Medicine, Menoufia Unive , Menoufia , Egypt )
  • Abdelazeem, Basel  ( West Virginia University , Morgantown , West Virginia , United States )
  • Abdelaziz, Ahmed  ( Faculty of medicine Al-Azhar university in Cairo , Cairo , Egypt )
  • Hassan, Atef  ( Faculty of medicine Al-Azhar university in Cairo , Cairo , Egypt )
  • Hageen, Ahmed Wael  ( Faculty of Medicine, Tanta University, Tanta, Egypt , Tanta , Egypt )
  • Ramadan, Shrouk  ( Ain Shams University , Cairo , Egypt )
  • Mohamed, Ahmed  ( Faculty of medicine, Tanta university , El mahallah e kobra , Egypt )
  • Nasr, Ahmed  ( Damietta faculty of medicine, Al-Azher university , Clifton , New Jersey , United States )
  • Afify, Raneem  ( Facylty of medicine, Tanta universi , El mahallah el kobra , Egypt )
  • Banour, Sandi  ( ruby hospital , Virginia , Virginia , United States )
  • Author Disclosures:
    Ahmed Farid Gadelmawla: DO NOT have relevant financial relationships | Basel Abdelazeem: DO NOT have relevant financial relationships | Ahmed Abdelaziz: DO NOT have relevant financial relationships | Atef Hassan: DO NOT have relevant financial relationships | Ahmed Wael Hageen: DO NOT have relevant financial relationships | Shrouk Ramadan: DO NOT have relevant financial relationships | Ahmed Mohamed: DO NOT have relevant financial relationships | Ahmed Nasr: DO NOT have relevant financial relationships | Raneem Afify: DO NOT have relevant financial relationships | Sandi Banour: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Insight Into Electrophysiologic Realities Gained From the ECG

Monday, 11/18/2024 , 01:30PM - 02:30PM

Abstract Poster Session

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