Logo

American Heart Association

  9
  0


Final ID: Su4127

Fully Ungated, Free-Breathing, 3-Dimentional T2* Mapping for Imaging Hemorrhagic Myocardial Infarction

Abstract Body (Do not enter title and authors here):
Introduction:
T2* cardiac MRI (CMR) is the standard for detecting hemorrhagic myocardial infarction (MI). However, the conventional T2* CMR (2D breath-held, ECG-gated, multi-gradient-echo T2*) can suffer from limited spatial resolution and multiple motion artifacts. We developed a time-efficient, fully ungated, free breathing, 3D T2* mapping method for detecting and characterizing hemorrhagic MI (hMI).
Methods:
Our approach, developed using a low-rank tensor framework, was tested in a canine model with reperfused hMI. Animals (n=5) underwent CMR 3 days after reperfusion. Short-axis, conventional 2D and proposed 3D T2*-w images, and the corresponding LGE images were acquired in a 3T CMR system. T2* maps (8 echoes, 1.41-15.44 ms) were constructed using mono-exponential fitting. IMH extent was determined by measuring the weighted sum of the imaging slices with hypointense regions (based on ‘mean-2SD’ criterion) within the LGE positive territories. Image quality was assessed by two CMR experts using a Likert scale (1 – poor; and 5 - excellent).
Results:
Figure 1 shows representative conventional 2D, proposed 3D T2* images, along with LGE image for reference. T2* image scores were higher with the proposed than the conventional approach: 3.5 ± 0.5 (conventional) vs 3.8 ± 0.3 (proposed), p<0.05. IMH extent measured using the two approaches provided equivalent IMH extent (see Fig. 2) under stable imaging conditions.

Conclusions:
The proposed 3D T2* mapping can provide much needed improvement in image quality compared to conventional 2D T2* CMR for detection of hemorrhagic MI without the need for breath holding or cardiac gating, both of which are known problems in acute MI patients. Provided imaging conditions are favorable, we also found that the proposed and conventional methods yield equivalent estimates of IMH extent. Additional studies are needed to evaluate the benefits of the proposed approach in clinical setting.
  • Guan, Xingmin  ( Indiana University , San Diego , California , United States )
  • Prato, Frank  ( Lawson Health Research Institute , London , Ontario , Canada )
  • Dharmakumar, Rohan  ( Indiana University , San Diego , California , United States )
  • Yang, Hsin-jung  ( Cedars Sinai Medical Center , Los Angeles , California , United States )
  • Sykes, Jane  ( Lawson Health Research Institute , London , Ontario , Canada )
  • Wang, Nan  ( Cedars Sinai Medical Center , Los Angeles , California , United States )
  • Zhang, Xinheng  ( Indiana University , San Diego , California , United States )
  • Tang, Richard  ( Indiana University , San Diego , California , United States )
  • Christodoulou, Anthony  ( CEDARS-SINAI MEDICAL CENTER , W Hollywood , California , United States )
  • Sharif, Behzad  ( Indiana University , San Diego , California , United States )
  • Li, Debiao  ( CEDARS-SINAI MEDICAL CENTER , W Hollywood , California , United States )
  • Author Disclosures:
    Xingmin Guan: DO NOT have relevant financial relationships | Frank Prato: DO NOT have relevant financial relationships | Rohan Dharmakumar: No Answer | Hsin-jung Yang: DO NOT have relevant financial relationships | Jane Sykes: No Answer | Nan Wang: No Answer | Xinheng Zhang: No Answer | Richard Tang: DO NOT have relevant financial relationships | Anthony Christodoulou: DO have relevant financial relationships ; Research Funding (PI or named investigator):Siemens Healthineers:Expected (by end of conference) | Behzad Sharif: DO NOT have relevant financial relationships | Debiao Li: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

MRI Multiparametric Tools for Deciphering Controversial Diagnostic Challenges

Sunday, 11/17/2024 , 11:30AM - 12:30PM

Abstract Poster Session

More abstracts on this topic:
More abstracts from these authors:
Non-invasive, Radiation-free, Non-contrast Myocardial Volume Oxygen Consumption Quantification Using Free-breathing MR Blood Oximetry

Yang Chia Chi, Han Hui, Dharmakumar Rohan, Yang Hsin-jung, Malagi Archana, Huang Li-ting, Huang Yuheng, Yoosefian Ghazal, Zhang Xinheng, Guan Xingmin, Christodoulou Anthony, Li Debiao

Quantitative, time-efficient viability cardiac magnetic resonance with delayed-phase dynamic contrast enhancement model: a pilot study in dogs with myocardial infarction

Huang Li-ting, Wei Janet, Bi Xiaoming, Christodoulou Anthony, Li Debiao, Han Hui, Dharmakumar Rohan, Yang Hsin-jung, Zhang Xinheng, Li Xinqi, Malagi Archana, Huang Yuheng, Guan Xingmin, Ho Hao, Kwan Alan

You have to be authorized to contact abstract author. Please, Login
Not Available