Scientific Sessions 2024  /  Charcuterie Board of Diet and Nutrition Research  /  Time-Restricted Eating Improves Heart Rate, Symptoms, and Quality of Life Metrics in Patients With Postural Orthostatic Tachycardia Syndrome
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American Heart Association

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Final ID: MDP1567

Time-Restricted Eating Improves Heart Rate, Symptoms, and Quality of Life Metrics in Patients With Postural Orthostatic Tachycardia Syndrome

Abstract Body (Do not enter title and authors here):
Introduction/Hypothesis

Time-restricted eating (TRE) is a lifestyle intervention in which there is an extended fasting period overnight of about 14 hours with a 10-hour eating window. Clinical and animal studies have shown that TRE decreases inflammation, and improves immune autonomic and mitochondrial function and cardiometabolic parameters. Patients with POTS have derangements in many of these parameters resulting in the hypothesis that TRE could be beneficial for patients with POTS.

Methods/Approach

20 participants aged 18-70 (M=36 years ±11.79), all on pharmacological therapy for POTS, met inclusion criteria: ≥12-hour dietary window and established POTS diagnosis (≥30 bpm increase in upright heart rate). After a 2-week baseline period of monitoring via myCircadianClock App, to ensure baseline eating window was ≥12 hours, participants entered a 12-week TRE intervention, consuming calories within an 8-10 hour eating window. Pre/post-intervention assessments included a 10-minute stand test and QOL questionnaires (SF-36 and MALMO POTS).

Results/Data

Orthostatic assessments comparing pre and post-intervention standing tests revealed reduction in heart rate increase. 19 of the 20 participants experienced this improvement, with the mean decrease in heart rate change (Figure 1A) averaging approximately 11 bpm (p < 0.001). Additionally, outcomes from the MALMO POTS Symptom Score Survey (MALMO) (Figure 1B) and the Short Form (36) Health Survey (SF-36) showcased substantial enhancements in participants' QOL. These improvements were evidenced by reductions in POTS symptom severity (p < 0.0001) and notable enhancements in physical functioning (p = 0.015) and energy/fatigue levels (p < 0.01).

Conclusion

In this pilot study, TRE improved heart rate, symptoms and QOL in patients with POTS, who are on background medical therapy, suggesting this lifestyle intervention could be beneficial for patients with POTS.
  • Dzotsi, Marissa  ( UCSD MEDICAL CENTER , La Jolla , California , United States )
  • Strohm, Allyssa  ( UCSD MEDICAL CENTER , La Jolla , California , United States )
  • Manoogian, Emily  ( Salk Institute , La Jolla , California , United States )
  • Panda, Satchidananda  ( Salk Institute , La Jolla , California , United States )
  • Doherty, Taylor  ( UCSD MEDICAL CENTER , La Jolla , California , United States )
  • Taub, Pam  ( UCSD MEDICAL CENTER , La Jolla , California , United States )
    • Author Disclosures:
    Marissa Dzotsi: DO NOT have relevant financial relationships | Allyssa Strohm: No Answer | Emily Manoogian: DO have relevant financial relationships ; Individual Stocks/Stock Options:DEXCOM:Active (exists now) ; Individual Stocks/Stock Options:Abbott:Past (completed) | Satchidananda Panda: No Answer | Taylor Doherty: No Answer | Pam Taub: DO have relevant financial relationships ; Consultant:Amgen:Active (exists now) ; Consultant:Boehringer Ingelheim/Lilly:Active (exists now) ; Consultant:Sanofi:Active (exists now) ; Consultant:Medtronic:Active (exists now) ; Consultant:Edwards:Active (exists now) ; Consultant:Esperion:Active (exists now) ; Consultant:Novo Nordisk:Active (exists now) ; Consultant:Novartis:Active (exists now)
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Charcuterie Board of Diet and Nutrition Research

Monday, 11/18/2024 , 12:50PM - 02:15PM

Moderated Digital Poster Session

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