Logo

American Heart Association

  2
  0


Final ID: MDP860

Impact of reduced right ventricular function on prognosis or heart failure hospitalization in wild-type transthyretin cardiac amyloidosis

Abstract Body (Do not enter title and authors here): Background:Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is a disease that is increasingly diagnosed through non-invasive diagnostic procedures, including echocardiography and 99mTc-pyrophosphate scintigraphy, and advances in medical treatment. However, echocardiographic prognostic markers of ATTRwt-CA have not been fully clarified.
Aims: The aim of this study was to evaluate physical findings, biomarkers, and echocardiographic parameters related to prognosis and heart failure (HF) in patients with ATTRwt-CA.
Methods: Thirty-two consecutive patients diagnosed with ATTRwt-CA by myocardial biopsy at Yamaguchi University Hospital from April 2021 to March 2023 were included. Echocardiographic parameters associated with composite adverse outcomes including all-cause mortality or hospitalization for HF were examined.
Results: During an average follow-up period of 542 days,3patients died and 3 patients were hospitalized for HF. The proportion of male was 91%, the mean NYHA was 1.9, and 44% had a history of HF hospitalization. The average of left ventricular ejection fraction (LVEF) was 44.5%, and wall thickness averaged 13.5mm at interventricular septum. At univariate analysis, systolic blood pressure(systolic BP: 121mmHg vs. 99mmHg, p<0.01), diastolic BP (68mmHg vs. 56mmHg, P<0.05), NT-pro BNP (2304pg/ml vs. 5875pg/ml, p<0.01), right ventricular (RV) basal diameter (37mm vs. 41mm, p<0.05), tricuspid annular plane systolic excursion (16.5mm vs. 14.5mm, p<0.05), right ventricular fractional area change (38% vs. 28%, p<0.01), right atrial volume index (37.2ml/m2 vs. 55.2ml/m2, p<0.05) were significantly associated with the composite adverse outcome. Left-sided echocardiographic parameters including LV diameter, LVEF, stroke volume index, E/E’, global longitudinal strain, and left atrial reservoir strain were not associated with outcome.
Conclusion: In ATTRwt-CA, in addition to NT-pro BNP and BP, the presence of decreased RV function may correlate with prognosis or HF admission.
  • Omuro, Ayumi  ( Yamaguchi University , Ube , Japan )
  • Okamura, Takayuki  ( Yamaguchi University , Ube , Japan )
  • Sano, Motoaki  ( Yamaguchi University , Ube , Japan )
  • Okuda, Shinichi  ( Yamaguchi University , Ube , Japan )
  • Tamitani, Masaki  ( Yamaguchi University , Ube , Japan )
  • Nawata, Junya  ( Yamaguchi University , Ube, Yamaguchi , Japan )
  • Nakashima, Yusuke  ( Yamaguchi university , Ube , Japan )
  • Miho, Fujita  ( Yamaguchi University , Ube , Japan )
  • Murakawa, Kaori  ( Yamaguchi University , Ube , Japan )
  • Uno, Moe  ( Yamaguchi University , Ube , Japan )
  • Masamune, Uchida  ( Yamaguchi University , Ube , Japan )
  • Author Disclosures:
    Ayumi Omuro: DO NOT have relevant financial relationships | Takayuki Okamura: No Answer | Motoaki Sano: No Answer | Shinichi Okuda: DO NOT have relevant financial relationships | MASAKI TAMITANI: No Answer | Junya Nawata: DO NOT have relevant financial relationships | Yusuke Nakashima: DO NOT have relevant financial relationships | Fujita Miho: No Answer | Kaori Murakawa: No Answer | Moe Uno: No Answer | Uchida Masamune: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Cardiac Amyloidosis 2024: Advances in Prognostication and Management

Sunday, 11/17/2024 , 11:10AM - 12:35PM

Moderated Digital Poster Session

More abstracts on this topic:
Assessing Prevalence of Cardiac Amyloidosis at the Time of Spinal Laminectomy for Spinal Stenosis

Sul Lidiya, Cotta Claudiu, Nakashima Megan, Steinmetz Michael, Kilpatrick Scott, Reith John, Hanna Mazen, Ives Lauren, Schlenk Richard, Kalfas Iain, Mroz Thomas, Orr Doug, Benzel Edward, Krishnaney Ajit, Pelle Dominic

Advanced Machine Learning Models for Classifying Transthyretin Amyloidosis in Clinical Settings

Verma Anurag, Hsu Po-ya, Kripke Colleen, Howard William, Sirugo Giorgio, Myes Kelly

More abstracts from these authors:
Role of serial evaluation of myocardial inflammatory activity and oxidative stress in determining the therapeutic efficacy of immunosuppression and clinical outcome in patients with cardiac sarcoidosis

Nakashima Yusuke, Kobayashi Shigeki, Ishikawa Maho, Nawata Junya, Nakamura Yoshihide, Fujimura Tatsuhiro, Sano Motoaki

Add-on Therapy with Dantrolene, a RyR2 Stabilizer, Terminates Ventricular Tachycardia Storm refractory to Intravenous Amiodarone in Heart Failure.

Nawata Junya, Omuro Ayumi, Fukuda Masakazu, Suetomi Takeshi, Miyazaki Yosuke, Fujimura Tatsuhiro, Mochizuki Mamoru, Sano Motoaki, Kobayashi Shigeki, Ishikawa Maho, Nakata Yuki, Murakawa Kaori, Nakashima Yusuke, Hisaoka Masahiro, Matsuyama Tetsuya, Nakamura Yoshihide

You have to be authorized to contact abstract author. Please, Login
Not Available