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American Heart Association

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Final ID: MDP1489

Aortic Valve Calcification Density Performs Better Compared to Absolute Aortic Valve Calcification in Aortic Stenosis Risk Stratification

Abstract Body (Do not enter title and authors here): Aortic valve calcification (AVC) scores can be used to stratify aortic stenosis (AS) severity. Current practice guidelines recommend use of absolute AVC scores without considering body surface area or aortic annulus size. We investigated whether size variation in aortic annular area should be considered in identifying optimal AVC cutoffs for patients with severe AS.

This was a retrospective analysis of AS patients that underwent AVC assessment during 2018-2023. Outcomes were composite of valve intervention or all-cause mortality. AVC density was defined by dividing AVC by echo-derived left ventricular tract area. Receiver operator curve analysis determined optimal AVC density scores. Absolute AVC cutoffs of >1200AU for females and >2000AU for males were used to identify severe AS.

The study included 749 patients (mean age 78 years, 46% female). Median CT-annulus area was larger for males compared with females (532mm2 [Q1, Q3: 479, 582] vs. 413mm2 [370, 458], p<0.001). There was a strong association of absolute AVC with CT-annulus area for both males and females (Spearman coefficient: 0.87 and 0.83, p<0.01 each) respectively (Figure 1). The optimal AVC density cutoffs for males and females were 427 and 326, respectively (accuracy 76%, sensitivity 83%, specificity 51%). Composite outcomes were better differentiated with AVC density (males: HR 2.48, 95% CI: 1.82-3.37, p<0.001; females: HR 2.37 (1.71-3.28), p<0.001) compared with absolute AVC scores (males: HR 1.81 (1.43-2.30), p<0.001; females: HR 2.11 (1.62-2.74), p<0.001) (Figure 2).

AVC is strongly associated with CT-annulus area and risk stratification is improved with the use of AVC density compared with absolute AVC. This may be especially helpful in patients with extremes of annulus area sizes.
  • Ahmad, Syed  ( West Virginia University , Morgantown , West Virginia , United States )
  • Zeb, Irfan  ( West Virginia University Hospital , MORGANTOWN , West Virginia , United States )
  • Watson, Hangyu  ( West Virginia University , Morgantown , West Virginia , United States )
  • Awad, Maan  ( West Virginia University , Morgantown , West Virginia , United States )
  • Patel, Kunal  ( West Virginia University , Morgantown , West Virginia , United States )
  • Nassar, Sameh  ( West Virginia University , Morgantown , West Virginia , United States )
  • Thyagaturu, Harshith  ( West Virginia University , Morgantown , West Virginia , United States )
  • Balla, Sudarshan  ( West Virginia University Hospital , MORGANTOWN , West Virginia , United States )
  • Kawsara, Mohammad  ( West Virginia University Hospital , MORGANTOWN , West Virginia , United States )
  • Daggubati, Ramesh  ( West Virginia University Hospital , MORGANTOWN , West Virginia , United States )
  • Author Disclosures:
    Syed Ahmad: DO NOT have relevant financial relationships | Irfan Zeb: No Answer | HangYu Watson: DO NOT have relevant financial relationships | Maan Awad: DO NOT have relevant financial relationships | Kunal Patel: DO NOT have relevant financial relationships | Sameh Nassar: DO NOT have relevant financial relationships | Harshith Thyagaturu: DO NOT have relevant financial relationships | Sudarshan Balla: DO NOT have relevant financial relationships | Mohammad Kawsara: No Answer | Ramesh Daggubati: DO have relevant financial relationships ; Consultant:Medtronic Inc:Past (completed)
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Advances in Native and Replaced Valves Care Research

Monday, 11/18/2024 , 11:10AM - 12:35PM

Moderated Digital Poster Session

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