Scientific Sessions 2024  /  The Next Frontier: Novel Molecular Mechanisms of Pulmonary Hypertension
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American Heart Association

Scientific Sessions 2024

The Next Frontier: Novel Molecular Mechanisms of Pulmonary Hypertension

Moderated Digital Poster Session

Zone 4, Moderated Digital Poster 17

Nov 18th , 09:30 AM - 11:00 AM

Showing 8 Results.

09 : 30 AM

C-C motif chemokine receptor-2 disruption Synergizes with Phosphodiesterase Type 5 Inhibition in Ameliorating Pulmonary Hypertension in Monocrotaline-treated Rats: Proof-of-Concept Study for a Combination therapy and Potential Mechanisms

Tsuboya Naoki,  Okamoto Ryuji,  Mashimo Tomoji,  Dohi Kaoru,  Nishimura Yuhei,  Maruyama Kazuo,  Hirayama Masahiro,  Mitani Yoshihide,  Sawada Hirofumi,  Takeoka Mami,  Ohya Kazunobu,  Oshita Hironori,  Yodoya Noriko,  Ohashi Hiroyuki,  Maruyama Junko

Final Pr. ID: MDP1644

Authors:  Tsuboya Naoki,  Okamoto Ryuji,  Mashimo Tomoji,  Dohi Kaoru,  Nishimura Yuhei,  Maruyama Kazuo,  Hirayama Masahiro,  Mitani Yoshihide,  Sawada Hirofumi,  Takeoka Mami,  Ohya Kazunobu,  Oshita Hironori,  Yodoya Noriko,  Ohashi Hiroyuki,  Maruyama Junko

Keywords:  Pulmonary hypertension ,  Inflammation and inflammatory markers ,  Pulmonary circulation

09 : 40 AM

Targeting Aurora Kinase B Improves Vascular Remodeling in Pulmonary Arterial Hypertension

Lemay Sarah-eve,  Bourgeois Alice,  Romanet Charlotte,  Breuils Bonnet Sandra,  Montesinos Monica,  Lu Min,  Chen Huidong,  Theberge Charlie,  Potus Francois,  Savai Pullamsetti Soni,  Provencher Steeve,  Mougin Manon,  Bonnet Sebastien,  Boucherat Olivier,  Sauvaget Melanie,  Reem El-kabbout,  Valasarajan Chanil,  Yamamoto Keiko,  Martineau Sandra,  Pelletier Andreanne,  Grobs Yann

Final Pr. ID: MDP1645

Authors:  Lemay Sarah-eve,  Bourgeois Alice,  Romanet Charlotte,  Breuils Bonnet Sandra,  Montesinos Monica,  Lu Min,  Chen Huidong,  Theberge Charlie,  Potus Francois,  Savai Pullamsetti Soni,  Provencher Steeve,  Mougin Manon,  Bonnet Sebastien,  Boucherat Olivier,  Sauvaget Melanie,  Reem El-kabbout,  Valasarajan Chanil,  Yamamoto Keiko,  Martineau Sandra,  Pelletier Andreanne,  Grobs Yann

Keywords:  Pulmonary hypertension

09 : 50 AM

Treatment of pulmonary arterial hypertension by blocking integrin a5b1, a potential disease-modifying strategy

Montesinos Monica,  Moy Terence I.,  Smukste Inese,  Mcteague T. Andrew,  Dowling James,  Lama Sujan,  Pondish Jessica,  Qiao Qi,  Monroy Meghan Monroy,  Lin Albert,  Wang Hua,  Lemay Sarah-eve,  Boucherat Olivier,  Sauvaget Melanie,  Potus Francois,  Breuils Bonnet Sandra,  Theberge Charlie,  Provencher Steeve,  Ray Adrian,  Lippa Blaise,  Bonnet Sebastien,  Goodwin Bryan,  Kapoor Parmita,  Lu Min,  Rapisardi Hailey,  Nguyen Minh Hai,  Kim Haejin,  Akram Muzaffar,  Jain Dhawal,  Konopka Elizabeth

Final Pr. ID: MDP1646

Authors:  Montesinos Monica,  Moy Terence I.,  Smukste Inese,  Mcteague T. Andrew,  Dowling James,  Lama Sujan,  Pondish Jessica,  Qiao Qi,  Monroy Meghan Monroy,  Lin Albert,  Wang Hua,  Lemay Sarah-eve,  Boucherat Olivier,  Sauvaget Melanie,  Potus Francois,  Breuils Bonnet Sandra,  Theberge Charlie,  Provencher Steeve,  Ray Adrian,  Lippa Blaise,  Bonnet Sebastien,  Goodwin Bryan,  Kapoor Parmita,  Lu Min,  Rapisardi Hailey,  Nguyen Minh Hai,  Kim Haejin,  Akram Muzaffar,  Jain Dhawal,  Konopka Elizabeth

Keywords:  Vascular disease ,  Pulmonary hypertension ,  Remodeling

10 : 00 AM

Interleukin-22 Prevents Right Ventricular Remodeling and Tricuspid Regurgitation during Pressure Overload through a Unique Mechanism

Shibao Kodai,  Yasukawa Hideo,  Akagaki Daiki,  Okabe Kota,  Yanai Toshiyuki,  Shima Kanako,  Yamamoto Mai,  Fukumoto Yoshihiro

Final Pr. ID: MDP1647

Authors:  Shibao Kodai,  Yasukawa Hideo,  Akagaki Daiki,  Okabe Kota,  Yanai Toshiyuki,  Shima Kanako,  Yamamoto Mai,  Fukumoto Yoshihiro

Keywords:  Right Ventricular Dysfunction ,  Pulmonary hypertension ,  Molecular

10 : 10 AM

Transcription factor LITAF orchestrates pericyte-mediated vascular inflammation via modulation of protein trafficking pathways in pulmonary hypertension

Chelladurai Prakash,  Yuan Ke,  Dejesus Vinicio,  Condon David,  Agarwal Stuti,  Mitra Ankita,  Shamskhou Kian,  Nathan Abinaya,  Sweatt Andrew,  Chakraborty Ananya,  Zamanian Roham

Final Pr. ID: MDP1648

Authors:  Chelladurai Prakash,  Yuan Ke,  Dejesus Vinicio,  Condon David,  Agarwal Stuti,  Mitra Ankita,  Shamskhou Kian,  Nathan Abinaya,  Sweatt Andrew,  Chakraborty Ananya,  Zamanian Roham

Keywords:  Vascular disease ,  Pulmonary circulation ,  Inflammation and inflammatory markers ,  Targeted therapeutics ,  Epigenetics

10 : 20 AM

SOX17 Deficiency is Additive to High Shear Stress in Reducing Endothelial Genes Linked to BMPR2 and NOTCH and Promoting Inflammation in Pulmonary Arterial Hypertension

Zhang Chongyang,  Shinohara Tsutomu,  Lee-yow Yannick,  Guo Kathrine,  Lago-docampo Mauro,  Engreitz Jesse,  Rabinovitch Marlene

Final Pr. ID: MDP1649

Authors:  Zhang Chongyang,  Shinohara Tsutomu,  Lee-yow Yannick,  Guo Kathrine,  Lago-docampo Mauro,  Engreitz Jesse,  Rabinovitch Marlene

Keywords:  Pulmonary artery ,  Pulmonary hypertension ,  Endothelial function

10 : 30 AM

Reduced BMPR2 in Monocytes De-represses HERV-K and Sustains Inflammation in Pulmonary Arterial Hypertension

Adil Mir,  Cao Aiqin,  Lago-docampo Mauro,  Zhang Chongyang,  Rabinovitch Marlene

Final Pr. ID: MDP1650

Authors:  Adil Mir,  Cao Aiqin,  Lago-docampo Mauro,  Zhang Chongyang,  Rabinovitch Marlene

Keywords:  Inflammation ,  Blood cells ,  Cell signaling ,  Immune system ,  Gene expression

10 : 40 AM

Targeting Hepatic Complement C3 Attenuates Pulmonary Arterial Hypertension Phenotype in Rodents

Keles Merve,  Lawrie Allan,  Arnold Nadine,  West Laura,  Turton Helena,  Kim Sung-kwon,  Lasaro Melissa,  Rammanujam Meera,  Chang C-hong,  Wilkins M

Final Pr. ID: MDP1651

Authors:  Keles Merve,  Lawrie Allan,  Arnold Nadine,  West Laura,  Turton Helena,  Kim Sung-kwon,  Lasaro Melissa,  Rammanujam Meera,  Chang C-hong,  Wilkins M

Keywords:  Pulmonary hypertension ,  Pulmonary circulation

09 : 30 AM

C-C motif chemokine receptor-2 disruption Synergizes with Phosphodiesterase Type 5 Inhibition in Ameliorating Pulmonary Hypertension in Monocrotaline-treated Rats: Proof-of-Concept Study for a Combination therapy and Potential Mechanisms

Tsuboya Naoki,  Okamoto Ryuji,  Mashimo Tomoji,  Dohi Kaoru,  Nishimura Yuhei,  Maruyama Kazuo,  Hirayama Masahiro,  Mitani Yoshihide,  Sawada Hirofumi,  Takeoka Mami,  Ohya Kazunobu,  Oshita Hironori,  Yodoya Noriko,  Ohashi Hiroyuki,  Maruyama Junko

Final Pr. ID: MDP1644

Authors:  Tsuboya Naoki,  Okamoto Ryuji,  Mashimo Tomoji,  Dohi Kaoru,  Nishimura Yuhei,  Maruyama Kazuo,  Hirayama Masahiro,  Mitani Yoshihide,  Sawada Hirofumi,  Takeoka Mami,  Ohya Kazunobu,  Oshita Hironori,  Yodoya Noriko,  Ohashi Hiroyuki,  Maruyama Junko

Keywords:  Pulmonary hypertension ,  Inflammation and inflammatory markers ,  Pulmonary circulation

2

10 : 00 AM

Interleukin-22 Prevents Right Ventricular Remodeling and Tricuspid Regurgitation during Pressure Overload through a Unique Mechanism

Shibao Kodai,  Yasukawa Hideo,  Akagaki Daiki,  Okabe Kota,  Yanai Toshiyuki,  Shima Kanako,  Yamamoto Mai,  Fukumoto Yoshihiro

Final Pr. ID: MDP1647

Authors:  Shibao Kodai,  Yasukawa Hideo,  Akagaki Daiki,  Okabe Kota,  Yanai Toshiyuki,  Shima Kanako,  Yamamoto Mai,  Fukumoto Yoshihiro

Keywords:  Right Ventricular Dysfunction ,  Pulmonary hypertension ,  Molecular

1

10 : 30 AM

Reduced BMPR2 in Monocytes De-represses HERV-K and Sustains Inflammation in Pulmonary Arterial Hypertension

Adil Mir,  Cao Aiqin,  Lago-docampo Mauro,  Zhang Chongyang,  Rabinovitch Marlene

Final Pr. ID: MDP1650

Authors:  Adil Mir,  Cao Aiqin,  Lago-docampo Mauro,  Zhang Chongyang,  Rabinovitch Marlene

Keywords:  Inflammation ,  Blood cells ,  Cell signaling ,  Immune system ,  Gene expression

1

10 : 20 AM

SOX17 Deficiency is Additive to High Shear Stress in Reducing Endothelial Genes Linked to BMPR2 and NOTCH and Promoting Inflammation in Pulmonary Arterial Hypertension

Zhang Chongyang,  Shinohara Tsutomu,  Lee-yow Yannick,  Guo Kathrine,  Lago-docampo Mauro,  Engreitz Jesse,  Rabinovitch Marlene

Final Pr. ID: MDP1649

Authors:  Zhang Chongyang,  Shinohara Tsutomu,  Lee-yow Yannick,  Guo Kathrine,  Lago-docampo Mauro,  Engreitz Jesse,  Rabinovitch Marlene

Keywords:  Pulmonary artery ,  Pulmonary hypertension ,  Endothelial function

1

09 : 40 AM

Targeting Aurora Kinase B Improves Vascular Remodeling in Pulmonary Arterial Hypertension

Lemay Sarah-eve,  Bourgeois Alice,  Romanet Charlotte,  Breuils Bonnet Sandra,  Montesinos Monica,  Lu Min,  Chen Huidong,  Theberge Charlie,  Potus Francois,  Savai Pullamsetti Soni,  Provencher Steeve,  Mougin Manon,  Bonnet Sebastien,  Boucherat Olivier,  Sauvaget Melanie,  Reem El-kabbout,  Valasarajan Chanil,  Yamamoto Keiko,  Martineau Sandra,  Pelletier Andreanne,  Grobs Yann

Final Pr. ID: MDP1645

Authors:  Lemay Sarah-eve,  Bourgeois Alice,  Romanet Charlotte,  Breuils Bonnet Sandra,  Montesinos Monica,  Lu Min,  Chen Huidong,  Theberge Charlie,  Potus Francois,  Savai Pullamsetti Soni,  Provencher Steeve,  Mougin Manon,  Bonnet Sebastien,  Boucherat Olivier,  Sauvaget Melanie,  Reem El-kabbout,  Valasarajan Chanil,  Yamamoto Keiko,  Martineau Sandra,  Pelletier Andreanne,  Grobs Yann

Keywords:  Pulmonary hypertension

1

10 : 40 AM

Targeting Hepatic Complement C3 Attenuates Pulmonary Arterial Hypertension Phenotype in Rodents

Keles Merve,  Lawrie Allan,  Arnold Nadine,  West Laura,  Turton Helena,  Kim Sung-kwon,  Lasaro Melissa,  Rammanujam Meera,  Chang C-hong,  Wilkins M

Final Pr. ID: MDP1651

Authors:  Keles Merve,  Lawrie Allan,  Arnold Nadine,  West Laura,  Turton Helena,  Kim Sung-kwon,  Lasaro Melissa,  Rammanujam Meera,  Chang C-hong,  Wilkins M

Keywords:  Pulmonary hypertension ,  Pulmonary circulation

1

10 : 10 AM

Transcription factor LITAF orchestrates pericyte-mediated vascular inflammation via modulation of protein trafficking pathways in pulmonary hypertension

Chelladurai Prakash,  Yuan Ke,  Dejesus Vinicio,  Condon David,  Agarwal Stuti,  Mitra Ankita,  Shamskhou Kian,  Nathan Abinaya,  Sweatt Andrew,  Chakraborty Ananya,  Zamanian Roham

Final Pr. ID: MDP1648

Authors:  Chelladurai Prakash,  Yuan Ke,  Dejesus Vinicio,  Condon David,  Agarwal Stuti,  Mitra Ankita,  Shamskhou Kian,  Nathan Abinaya,  Sweatt Andrew,  Chakraborty Ananya,  Zamanian Roham

Keywords:  Vascular disease ,  Pulmonary circulation ,  Inflammation and inflammatory markers ,  Targeted therapeutics ,  Epigenetics

1

09 : 50 AM

Treatment of pulmonary arterial hypertension by blocking integrin a5b1, a potential disease-modifying strategy

Montesinos Monica,  Moy Terence I.,  Smukste Inese,  Mcteague T. Andrew,  Dowling James,  Lama Sujan,  Pondish Jessica,  Qiao Qi,  Monroy Meghan Monroy,  Lin Albert,  Wang Hua,  Lemay Sarah-eve,  Boucherat Olivier,  Sauvaget Melanie,  Potus Francois,  Breuils Bonnet Sandra,  Theberge Charlie,  Provencher Steeve,  Ray Adrian,  Lippa Blaise,  Bonnet Sebastien,  Goodwin Bryan,  Kapoor Parmita,  Lu Min,  Rapisardi Hailey,  Nguyen Minh Hai,  Kim Haejin,  Akram Muzaffar,  Jain Dhawal,  Konopka Elizabeth

Final Pr. ID: MDP1646

Authors:  Montesinos Monica,  Moy Terence I.,  Smukste Inese,  Mcteague T. Andrew,  Dowling James,  Lama Sujan,  Pondish Jessica,  Qiao Qi,  Monroy Meghan Monroy,  Lin Albert,  Wang Hua,  Lemay Sarah-eve,  Boucherat Olivier,  Sauvaget Melanie,  Potus Francois,  Breuils Bonnet Sandra,  Theberge Charlie,  Provencher Steeve,  Ray Adrian,  Lippa Blaise,  Bonnet Sebastien,  Goodwin Bryan,  Kapoor Parmita,  Lu Min,  Rapisardi Hailey,  Nguyen Minh Hai,  Kim Haejin,  Akram Muzaffar,  Jain Dhawal,  Konopka Elizabeth

Keywords:  Vascular disease ,  Pulmonary hypertension ,  Remodeling

1