American Heart Association
Genomics from Molecules to Patients to Populations
Moderated Digital Poster Session
Zone 1, Moderated Digital Poster 3
Nov 18th , 09:30 AM - 10:45 AM
09 : 30 AM
Variant-enhancer-gene mapping at the 9p21 locus in smooth muscle cells reveals new enhancer-gene pairs and mechanistic insights for coronary artery disease
Ramste Markus, Qin Guyu, Nguyen Trieu, Kim Juyong, Engreitz Jesse, Assimes Themistocles, Park Chong, Quertermous Thomas, Weldy Chad, Zhao Quanyi, Ramste Amanda, Li Daniel, Sharma Disha, Monteiro Joao, Worssam Matthew, Amgalan Dulguun
Final Pr. ID: MDP1316
Authors: Ramste Markus, Qin Guyu, Nguyen Trieu, Kim Juyong, Engreitz Jesse, Assimes Themistocles, Park Chong, Quertermous Thomas, Weldy Chad, Zhao Quanyi, Ramste Amanda, Li Daniel, Sharma Disha, Monteiro Joao, Worssam Matthew, Amgalan Dulguun
Keywords: Coronary artery calcification (CAC) , Coronary artery disease , Genome-wide association studies (GWAS) , Genomics , Vascular
09 : 40 AM
Investigation of familial hypercholesterolemia prevalence and association with cardiovascular disease in an African ancestry cohort.
Berry Alexander, Winters Alexandra, Kelly Melissa, Mohammed Nuha, Jones Laney, Gidding Samuel, Oetjens Matthew
Final Pr. ID: MDP1317
Authors: Berry Alexander, Winters Alexandra, Kelly Melissa, Mohammed Nuha, Jones Laney, Gidding Samuel, Oetjens Matthew
Keywords: Cardiovascular disease , Hypercholesterolemia , Genetics , LDL , Race
09 : 40 AM
Cardiovascular MRI-Derived Cardiac Age Acceleration is Associated with Shortened Leukocyte Telomere Length But Not Clonal Hematopoiesis of Indeterminate Potential
Brundage James, Barrios Joshua, Tison Geoffrey, Pirruccello James
Final Pr. ID: MDP1318
Authors: Brundage James, Barrios Joshua, Tison Geoffrey, Pirruccello James
Keywords: Aging , Deep learning , Genetics , Magnetic resonance imaging
09 : 50 AM
Identifying High-Risk Patients with Pathogenic Variants in LMNA Gene: Genome-First Approach
Krueger Seth, Matsumura Martin, Carruth Eric, Kelly Melissa
Final Pr. ID: MDP1319
Authors: Krueger Seth, Matsumura Martin, Carruth Eric, Kelly Melissa
Keywords: Genomics , Cardiomyopathy , Genetic testing , Genetics , Arrhythmias
10 : 00 AM
Genetic Influence in Patients Transplanted for Myocarditis in the TOPMed-TOPCHeF Cohort of Explanted Hearts
Jason Max, Mestroni Luisa, Taylor Matthew, Lombardi Raffaella, Graw Sharon, Medo Kristen, Newman Sarah, Bristow Michael, Ambardekar Amrut, Cleveland Joseph, Buttrick Peter
Final Pr. ID: MDP1320
Authors: Jason Max, Mestroni Luisa, Taylor Matthew, Lombardi Raffaella, Graw Sharon, Medo Kristen, Newman Sarah, Bristow Michael, Ambardekar Amrut, Cleveland Joseph, Buttrick Peter
Keywords: Myocarditis , Genes , environment , and lifestyle interactions , Gene mutations , Transplantation , Genomics
10 : 10 AM
Potential Protective Roles of Clonal Hematopoiesis of Indeterminate Potential in Angina Pectoris
Zheng Yidan, Zhu Da, Pan Xiangbin, Dong Nianguo, Xu Li, Li Fei, Zhou Zihao, Qian Xingyu, Hu Shiyan, Jingyu Xu, Liu Yuqi, Tong Fuqiang, Fan Pengning, Chen Zhe
Final Pr. ID: MDP1321
Authors: Zheng Yidan, Zhu Da, Pan Xiangbin, Dong Nianguo, Xu Li, Li Fei, Zhou Zihao, Qian Xingyu, Hu Shiyan, Jingyu Xu, Liu Yuqi, Tong Fuqiang, Fan Pengning, Chen Zhe
Keywords: Gene mutations , Angina pectoris , Atherogenic , Blood cells , Immunology
10 : 20 AM
Clonal Hematopoiesis of Indeterminate Potential Increases Mortality Risk in Coronary Artery Disease
Von Scheidt Moritz, Hao Ke, Steigerwald Sophia, Kessler Thorsten, Mokry Michal, Bongiovanni Dario, Fleig Julia, Oldenbuettel Lilith, Chen Zhifen, Hecker Judith S., Bassermann Florian, Adkar Shaunak, Maegdefessel Lars, Graw Matthias, Ruusalepp Arno, Hilgendorf Ingo, Leuschner Florian, Koenig Wolfgang, Cremer Sebastian, Leistner David, Dimmeler Stefanie, Zeiher Andreas, Krefting Johannes, Braun Christian, Mitchell Shaneice, Jaiswal Siddhartha, Kovacic Jason, Mann Matthias, Kastrati Adnan, Haferlach Claudia, Haferlach Torsten, Leeper Nick, Björkegren Johan, Hoermann Gregor, Schunkert Heribert, Meggendorfer Manja, Bauer Sabine, Pugach Irina, Friess Christian, Ma Angela
Final Pr. ID: MDP1322
Authors: Von Scheidt Moritz, Hao Ke, Steigerwald Sophia, Kessler Thorsten, Mokry Michal, Bongiovanni Dario, Fleig Julia, Oldenbuettel Lilith, Chen Zhifen, Hecker Judith S., Bassermann Florian, Adkar Shaunak, Maegdefessel Lars, Graw Matthias, Ruusalepp Arno, Hilgendorf Ingo, Leuschner Florian, Koenig Wolfgang, Cremer Sebastian, Leistner David, Dimmeler Stefanie, Zeiher Andreas, Krefting Johannes, Braun Christian, Mitchell Shaneice, Jaiswal Siddhartha, Kovacic Jason, Mann Matthias, Kastrati Adnan, Haferlach Claudia, Haferlach Torsten, Leeper Nick, Björkegren Johan, Hoermann Gregor, Schunkert Heribert, Meggendorfer Manja, Bauer Sabine, Pugach Irina, Friess Christian, Ma Angela
Keywords: Aging , Atherosclerosis , Cardiovascular , Inflammation , Lipids
10 : 30 AM
Disease-associated variants in DSP-encoded desmoplakin are common, yet low penetrant alleles associated with development of myocarditis and cardiomyopathy at a population level
Gurumoorthi Manasa, Sharaf Dabbagh Ghaith, Hesse Kerrick, Wolfe Rachel, Shah Ravi, Kurzlechner Leonie, Asatryan Babken, Chahal Anwar, Landstrom Andrew
Final Pr. ID: MDP1323
Authors: Gurumoorthi Manasa, Sharaf Dabbagh Ghaith, Hesse Kerrick, Wolfe Rachel, Shah Ravi, Kurzlechner Leonie, Asatryan Babken, Chahal Anwar, Landstrom Andrew
Keywords: Cardiomyopathy , Precision medicine , Genetics , Myocarditis
09 : 40 AM
Cardiovascular MRI-Derived Cardiac Age Acceleration is Associated with Shortened Leukocyte Telomere Length But Not Clonal Hematopoiesis of Indeterminate Potential
Brundage James, Barrios Joshua, Tison Geoffrey, Pirruccello James
Final Pr. ID: MDP1318
Authors: Brundage James, Barrios Joshua, Tison Geoffrey, Pirruccello James
Keywords: Aging , Deep learning , Genetics , Magnetic resonance imaging
10 : 20 AM
Clonal Hematopoiesis of Indeterminate Potential Increases Mortality Risk in Coronary Artery Disease
Von Scheidt Moritz, Hao Ke, Steigerwald Sophia, Kessler Thorsten, Mokry Michal, Bongiovanni Dario, Fleig Julia, Oldenbuettel Lilith, Chen Zhifen, Hecker Judith S., Bassermann Florian, Adkar Shaunak, Maegdefessel Lars, Graw Matthias, Ruusalepp Arno, Hilgendorf Ingo, Leuschner Florian, Koenig Wolfgang, Cremer Sebastian, Leistner David, Dimmeler Stefanie, Zeiher Andreas, Krefting Johannes, Braun Christian, Mitchell Shaneice, Jaiswal Siddhartha, Kovacic Jason, Mann Matthias, Kastrati Adnan, Haferlach Claudia, Haferlach Torsten, Leeper Nick, Björkegren Johan, Hoermann Gregor, Schunkert Heribert, Meggendorfer Manja, Bauer Sabine, Pugach Irina, Friess Christian, Ma Angela
Final Pr. ID: MDP1322
Authors: Von Scheidt Moritz, Hao Ke, Steigerwald Sophia, Kessler Thorsten, Mokry Michal, Bongiovanni Dario, Fleig Julia, Oldenbuettel Lilith, Chen Zhifen, Hecker Judith S., Bassermann Florian, Adkar Shaunak, Maegdefessel Lars, Graw Matthias, Ruusalepp Arno, Hilgendorf Ingo, Leuschner Florian, Koenig Wolfgang, Cremer Sebastian, Leistner David, Dimmeler Stefanie, Zeiher Andreas, Krefting Johannes, Braun Christian, Mitchell Shaneice, Jaiswal Siddhartha, Kovacic Jason, Mann Matthias, Kastrati Adnan, Haferlach Claudia, Haferlach Torsten, Leeper Nick, Björkegren Johan, Hoermann Gregor, Schunkert Heribert, Meggendorfer Manja, Bauer Sabine, Pugach Irina, Friess Christian, Ma Angela
Keywords: Aging , Atherosclerosis , Cardiovascular , Inflammation , Lipids
10 : 30 AM
Disease-associated variants in DSP-encoded desmoplakin are common, yet low penetrant alleles associated with development of myocarditis and cardiomyopathy at a population level
Gurumoorthi Manasa, Sharaf Dabbagh Ghaith, Hesse Kerrick, Wolfe Rachel, Shah Ravi, Kurzlechner Leonie, Asatryan Babken, Chahal Anwar, Landstrom Andrew
Final Pr. ID: MDP1323
Authors: Gurumoorthi Manasa, Sharaf Dabbagh Ghaith, Hesse Kerrick, Wolfe Rachel, Shah Ravi, Kurzlechner Leonie, Asatryan Babken, Chahal Anwar, Landstrom Andrew
Keywords: Cardiomyopathy , Precision medicine , Genetics , Myocarditis
10 : 00 AM
Genetic Influence in Patients Transplanted for Myocarditis in the TOPMed-TOPCHeF Cohort of Explanted Hearts
Jason Max, Mestroni Luisa, Taylor Matthew, Lombardi Raffaella, Graw Sharon, Medo Kristen, Newman Sarah, Bristow Michael, Ambardekar Amrut, Cleveland Joseph, Buttrick Peter
Final Pr. ID: MDP1320
Authors: Jason Max, Mestroni Luisa, Taylor Matthew, Lombardi Raffaella, Graw Sharon, Medo Kristen, Newman Sarah, Bristow Michael, Ambardekar Amrut, Cleveland Joseph, Buttrick Peter
Keywords: Myocarditis , Genes , environment , and lifestyle interactions , Gene mutations , Transplantation , Genomics
09 : 50 AM
Identifying High-Risk Patients with Pathogenic Variants in LMNA Gene: Genome-First Approach
Krueger Seth, Matsumura Martin, Carruth Eric, Kelly Melissa
Final Pr. ID: MDP1319
Authors: Krueger Seth, Matsumura Martin, Carruth Eric, Kelly Melissa
Keywords: Genomics , Cardiomyopathy , Genetic testing , Genetics , Arrhythmias
09 : 40 AM
Investigation of familial hypercholesterolemia prevalence and association with cardiovascular disease in an African ancestry cohort.
Berry Alexander, Winters Alexandra, Kelly Melissa, Mohammed Nuha, Jones Laney, Gidding Samuel, Oetjens Matthew
Final Pr. ID: MDP1317
Authors: Berry Alexander, Winters Alexandra, Kelly Melissa, Mohammed Nuha, Jones Laney, Gidding Samuel, Oetjens Matthew
Keywords: Cardiovascular disease , Hypercholesterolemia , Genetics , LDL , Race
10 : 10 AM
Potential Protective Roles of Clonal Hematopoiesis of Indeterminate Potential in Angina Pectoris
Zheng Yidan, Zhu Da, Pan Xiangbin, Dong Nianguo, Xu Li, Li Fei, Zhou Zihao, Qian Xingyu, Hu Shiyan, Jingyu Xu, Liu Yuqi, Tong Fuqiang, Fan Pengning, Chen Zhe
Final Pr. ID: MDP1321
Authors: Zheng Yidan, Zhu Da, Pan Xiangbin, Dong Nianguo, Xu Li, Li Fei, Zhou Zihao, Qian Xingyu, Hu Shiyan, Jingyu Xu, Liu Yuqi, Tong Fuqiang, Fan Pengning, Chen Zhe
Keywords: Gene mutations , Angina pectoris , Atherogenic , Blood cells , Immunology
09 : 30 AM
Variant-enhancer-gene mapping at the 9p21 locus in smooth muscle cells reveals new enhancer-gene pairs and mechanistic insights for coronary artery disease
Ramste Markus, Qin Guyu, Nguyen Trieu, Kim Juyong, Engreitz Jesse, Assimes Themistocles, Park Chong, Quertermous Thomas, Weldy Chad, Zhao Quanyi, Ramste Amanda, Li Daniel, Sharma Disha, Monteiro Joao, Worssam Matthew, Amgalan Dulguun
Final Pr. ID: MDP1316
Authors: Ramste Markus, Qin Guyu, Nguyen Trieu, Kim Juyong, Engreitz Jesse, Assimes Themistocles, Park Chong, Quertermous Thomas, Weldy Chad, Zhao Quanyi, Ramste Amanda, Li Daniel, Sharma Disha, Monteiro Joao, Worssam Matthew, Amgalan Dulguun
Keywords: Coronary artery calcification (CAC) , Coronary artery disease , Genome-wide association studies (GWAS) , Genomics , Vascular