International Stroke Conference 2025  /  Ongoing Clinical Trials Posters  /  Optimal Target Low-Density Lipoprotein-Cholesterol Level for Small Vessel Occlusion Stroke (SVO70): Rationale and Design of a Prospective, Randomized, Open-Label, Blinded Endpoint Trial
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American Heart Association

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Final ID: OGCTP23

Optimal Target Low-Density Lipoprotein-Cholesterol Level for Small Vessel Occlusion Stroke (SVO70): Rationale and Design of a Prospective, Randomized, Open-Label, Blinded Endpoint Trial

Abstract Body: Background and aims
Lipid-lowering therapy constitutes a cornerstone of secondary prevention in ischemic stroke; however, current stroke guidelines remain deficient in providing optimal target low-density lipoprotein (LDL)-cholesterol levels tailored to the stroke subtypes. Most clinical trials on LDL-cholesterol management have not differentiated between stroke subtypes or have primarily focused on large artery atherosclerosis (LAA) stroke, leaving a gap in evidence for managing LDL-cholesterol in other stroke subtypes, e.g., small vessel occlusion (SVO) stroke. While hypertension is the leading risk factor for SVO strokes, the link between elevated LDL-cholesterol and SVO stroke is also recognized. Establishing optimal LDL-cholesterol targets for SVO stroke would significantly enhance secondary prevention strategies and improve patient outcome. Thus, we aim to compare intensive versus standard lipid-lowering in patients with SVO stroke.

Methods
SVO70 is a multicenter, prospective, randomized, open, blinded-endpoint clinical trial. Adult patients with objectively confirmed SVO stroke within 180 days of randomization will be included. Exclusion criteria include those with predefined LDL-cholesterol targets for other conditions, statin contraindications, or women who are pregnant, breastfeeding, or planning pregnancy during the study period. Eligible participants will be randomized 1:1 to target LDL-cholesterol <70 mg/dL (intensive group) or 90-110 mg/dL (standard group). The trial plans to enroll 4,016 patients, with the primary outcome being major adverse cardiovascular events—cardiovascular death, stroke, and acute coronary syndrome—during a follow-up period of at least 4 years.

Status
The protocol of this study has been approved by the local institutional review board. The first participant was enrolled on October 4, 2024. The SVO70 trial is registered on ClinicalTrials.gov under the identifier NCT06649240.

Conclusions
This study would provide valuable information for determining the optimal LDL-cholesterol target for patients with SVO stroke.

Funding
This study is funded by Hanmi Pharmaceutical., which has no role in the study design, data collection, analysis, or interpretation.
  • Yang, Wookjin  ( Asan Medical Center , Seoul , Korea (the Republic of) )
  • Do, Young Rok  ( Daegu Catholic University Medical Center , Daegu , Korea (the Republic of) )
  • Sohn, Sung-il  ( Keimyung University Dongsan Medical Center , Daegu , Korea (the Republic of) )
  • Eun, Mi-yeon  ( Kyungpook National University Chilgok Hospital , Daegu , Korea (the Republic of) )
  • Hwang, Yang-ha  ( Kyungpook National University Hospital , Daegu , Korea (the Republic of) )
  • Jeong, Hye Seon  ( Chungnam National University Hospital , Daejeon , Korea (the Republic of) )
  • Kim, Jae Guk  ( Daejeon Eulji Medical Center , Daejeon , Korea (the Republic of) )
  • Jeong, Sang  ( Dongguk University Ilsan Hospital , Goyang , Korea (the Republic of) )
  • Cho, Yong-jin  ( Ilsan Paik Hospital , Goyang , Korea (the Republic of) )
  • Koh, Seong-ho  ( Hanyang University Guri Hospital , Guri , Korea (the Republic of) )
  • Kim, Joon-tae  ( Chonnam National University Hospital , Gwangju , Korea (the Republic of) )
  • Jung, Jin-man  ( Korea University Ansan Hospital , Ansan , Korea (the Republic of) )
  • Ahn, Seong Hwan  ( CHOSUN UNIVERSITY HOSPITAL , Gwangju , Korea (the Republic of) )
  • Ha, Samyeol  ( Chung-Ang University Gwangmyeong Hospital , Gwangmyeong , Korea (the Republic of) )
  • Mo, Heejung  ( Hallym University Dongtan Sacred Heart Hospital , Hwaseong , Korea (the Republic of) )
  • Park, Hyunyoung  ( Wonkwang University Hospital , Iksan , Korea (the Republic of) )
  • Lee, Yeong-bae  ( Gachon University Gil Medical Center , Incheon , Korea (the Republic of) )
  • Park, Hee-kwon  ( Inha University Hospital , Incheon , Korea (the Republic of) )
  • An, Sang Joon  ( International St. Mary's Hospital , Incheon , Korea (the Republic of) )
  • Choi, Jay Chol  ( Jeju National University Hospital , Jeju , Korea (the Republic of) )
  • Kim, Beom Joon  ( Seoul National University Bundang Hospital , Seongnam , Korea (the Republic of) )
  • Park, Kwang-yeol  ( Chung-Ang University Hospital , Seoul , Korea (the Republic of) )
  • Oh, Mi-sun  ( Hallym University Sacred Heart Hospital , Anyang , Korea (the Republic of) )
  • Chang, Yoonkyung  ( Ewha Womans University Mokdong Hospital , Seoul , Korea (the Republic of) )
  • Song, Tae-jin  ( Ewha Womans University Seoul Hospital , Seoul , Korea (the Republic of) )
  • Jung, Yo Han  ( Gangnam Severance Hospital , Seoul , Korea (the Republic of) )
  • Kim, Yerim  ( Hallym University Kangdong Sacred Heart Hospital , Seoul , Korea (the Republic of) )
  • Kim, Young Seo  ( Hanyang University Seoul Hospital , Seoul , Korea (the Republic of) )
  • Kim, Hahn Young  ( Konkuk University Medical Center , Seoul , Korea (the Republic of) )
  • Yu, Sungwook  ( Korea University Anam Hospital , Seoul , Korea (the Republic of) )
  • Heo, Sung Hyuk  ( Kyung Hee University Medical Center , Seoul , Korea (the Republic of) )
  • Lee, Jong Yun  ( National Medical Center , Seoul , Korea (the Republic of) )
  • Kang, Kyusik  ( Nowon Eulji Medical Center , Seoul , Korea (the Republic of) )
  • Cho, Han-jin  ( Pusan National University Hospital , Busan , Korea (the Republic of) )
  • Seo, Woo-keun  ( SAMSUNG MEDICAL CENTER , Seoul , Korea (the Republic of) )
  • Park, Tai  ( Seoul Medical Center , Seoul , Korea (the Republic of) )
  • Kwon, Hyung-min  ( Seoul Metropolitan Government-Seoul National University Boramae Medical Center , Seoul , Korea (the Republic of) )
  • Jang, Hyemin  ( Seoul National University Hospital, Seoul National University College of Medicine , Seoul , Korea (the Republic of) )
  • Kim, Jeong-min  ( Seoul National University Hospital, Seoul National University College of Medicine , Seoul , Korea (the Republic of) )
  • Jung, Keun-hwa  ( Seoul National University Hospital, Seoul National University College of Medicine , Seoul , Korea (the Republic of) )
  • Nam, Hyo Suk  ( Severance Hospital , Seoul , Korea (the Republic of) )
  • Cho, A-hyun  ( Yeouido St. Mary's Hospital , Seoul , Korea (the Republic of) )
  • Yoo, Joonsang  ( Yongin Severance Hospital , Yongin , Korea (the Republic of) )
  • Lee, Seung-hoon  ( Seoul National University Hospital, Seoul National University College of Medicine , Seoul , Korea (the Republic of) )
  • Jung, Seunguk  ( Gyeongsang National University Changwon Hospital , Changwon , Korea (the Republic of) )
  • Park, Jongho  ( Samsung Changwon Hospital , Changwon , Korea (the Republic of) )
  • Shin, Dong-ick  ( Chungbuk National University Hospital , Cheongju , Korea (the Republic of) )
  • Kim, Chulho  ( Hallym University Chuncheon Sacred Heart Hospital , Chuncheon , Korea (the Republic of) )
  • Kim, Seongheon  ( Kangwon National University Hospital , Chuncheon , Korea (the Republic of) )
    • Author Disclosures:
    Wookjin Yang: DO NOT have relevant financial relationships | Young Rok Do: No Answer | Sung-Il Sohn: No Answer | Mi-yeon Eun: DO NOT have relevant financial relationships | Yang-Ha Hwang: DO NOT have relevant financial relationships | Hye Seon Jeong: No Answer | Jae Guk Kim: DO NOT have relevant financial relationships | Sang Jeong: DO NOT have relevant financial relationships | Yong-Jin Cho: DO NOT have relevant financial relationships | Seong-Ho Koh: DO NOT have relevant financial relationships | Joon-Tae Kim: No Answer | Jin-Man Jung: DO NOT have relevant financial relationships | Seong Hwan Ahn: DO NOT have relevant financial relationships | Samyeol Ha: No Answer | HEEJUNG MO: DO NOT have relevant financial relationships | HyunYoung Park: No Answer | YEONG-BAE LEE: No Answer | Hee-Kwon Park: No Answer | Sang Joon An: DO NOT have relevant financial relationships | Jay Chol Choi: DO NOT have relevant financial relationships | Beom Joon Kim: DO NOT have relevant financial relationships | Kwang-yeol Park: DO NOT have relevant financial relationships | Mi-Sun Oh: No Answer | Yoonkyung Chang: DO NOT have relevant financial relationships | Tae-Jin Song: DO NOT have relevant financial relationships | Yo Han Jung: DO NOT have relevant financial relationships | Yerim Kim: DO NOT have relevant financial relationships | Young Seo Kim: DO NOT have relevant financial relationships | Hahn Young Kim: No Answer | Sungwook Yu: DO NOT have relevant financial relationships | Sung Hyuk Heo: DO NOT have relevant financial relationships | Jong Yun Lee: No Answer | Kyusik Kang: DO NOT have relevant financial relationships | Han-Jin Cho: No Answer | Woo-Keun Seo: DO NOT have relevant financial relationships | Tai Park: DO NOT have relevant financial relationships | Hyung-Min Kwon: DO NOT have relevant financial relationships | Hyemin Jang: DO NOT have relevant financial relationships | Jeong-Min Kim: No Answer | Keun-hwa Jung: DO NOT have relevant financial relationships | Hyo Suk Nam: DO NOT have relevant financial relationships | A-Hyun Cho: DO NOT have relevant financial relationships | Joonsang Yoo: No Answer | Seung-Hoon Lee: DO NOT have relevant financial relationships | Seunguk Jung: No Answer | Jongho Park: DO NOT have relevant financial relationships | Dong-Ick Shin: No Answer | Chulho Kim: No Answer | Seongheon Kim: DO NOT have relevant financial relationships
Meeting Info:

International Stroke Conference 2025

2025

Los Angeles, CA

Session Info:

Ongoing Clinical Trials Posters

Thursday, 02/06/2025 , 07:00PM - 07:30PM

Poster Abstract Session

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