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American Heart Association

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Final ID: TP263

Blood pressure trends during first forty-eight hours post arterial ischemic stroke in children with arteriopathy disease

Abstract Body: Introduction
Children with arteriopathy are at an increased risk to develop ischemic stroke that can lead to lifelong neurological deficits. Blood pressure is an important modifiable factor associated with poor neurological outcomes. However, there is a lack of sufficient evidence to provide patient specific blood pressure guidelines post pediatric ischemic stroke.
Objective
We aimed to evaluate blood pressure averages and changes in pediatric patients with arteriopathy within the first 48 hours in intensive care after an arterial ischemic stroke.
Method
We conducted a retrospective study of children diagnosed with acute arterial ischemic stroke admitted to the pediatric intensive care unit (PICU). We reviewed data on demographics, clinical outcome, radiologic, hemodynamic signs, and medication within PICU. Ischemic lesion volume size was obtained from Diffusion-Weighted Imaging by a full-trained neuroradiologist. Blood pressure percentile was obtained based on age, sex, and the 50th height rang. We also contrasted blood pressures of stroke patients with age and admission year matched controls without a history of stroke. We used linear regression to model blood pressure trends, t-test to compare continuous data, and chi square analyses to compare discrete data points.
Results
Forty-five patients (49% female, median age 7.8 years, range age 17 years) were included. Arteriopathy disease included Dissection, Moyamoya, Focal Cerebral Arteriopathy and Vasculitis. Despite only a minority of patients being on vasoactive medications, patients with arteriopathy had higher blood pressures compared to age-matched control PICU patients in the first 48 hours. In addition, 31% of arteriopathy patients had an average systolic blood pressure greater than the 95th percentile for the first two days after an acute arterial ischemic stroke, versus only 14% of their control (p-value < 0.05). Neurological deficits and increased brain ischemic lesion volume were associated with higher blood pressures.
Conclusion
Understanding blood pressure trends and outcomes after an ischemic stroke in children at risk is crucial to guide the management of this modifiable factor. Blood pressure in children with arteriopathy is increased after an ischemic stroke compared to controls admitted to PICU. Further research into the etiology of differences observed here and blood pressure management is crucial to reducing the burden of pediatric ischemic stroke on this at risk population.
  • Quesnel, Elya  ( University of Montreal , Montreal , Quebec , Canada )
  • Guerguerian, Anne-marie  ( Hospital for Sick Children , Toronto , Ontario , Canada )
  • Chin, Norbert  ( The Hospital for Sick Children , Toronto , Ontario , Canada )
  • Linds, Alexandra  ( The Hospital for Sick Children , Toronto , Ontario , Canada )
  • Sheng, Min  ( The Hospital for Sick Children , Toronto , Ontario , Canada )
  • Pulcine, Elizabeth  ( The Hospital for Sick Children , Toronto , Ontario , Canada )
  • Moharir, Mahendranath  ( HOSPITAL SICK CHILDREN , Toronto , Ontario , Canada )
  • Deveber, Gabrielle  ( Sickkids Research Institute , Toronto , Ontario , Canada )
  • Dlamini, Nomazulu  ( HOSPITAL FOR SICK CHILDREN , Toronto , Ontario , Canada )
  • Author Disclosures:
    Elya Quesnel: DO NOT have relevant financial relationships | Anne-Marie Guerguerian: No Answer | Norbert Chin: DO NOT have relevant financial relationships | Alexandra Linds: DO NOT have relevant financial relationships | Min Sheng: DO NOT have relevant financial relationships | Elizabeth Pulcine: DO NOT have relevant financial relationships | Mahendranath Moharir: DO NOT have relevant financial relationships | Gabrielle deVeber: DO NOT have relevant financial relationships | Nomazulu Dlamini: DO NOT have relevant financial relationships
Meeting Info:
Session Info:

Pediatric Cerebrovascular Disease Posters

Thursday, 02/06/2025 , 07:00PM - 07:30PM

Poster Abstract Session

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