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American Heart Association

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Final ID: WMP108

Pericarotid Fat Associated with Major Adverse Cardiovascular Events after Carotid Endarterectomy

Abstract Body: Background
Previous studies have linked pericoronary artery adipose tissue attenuation to major adverse cardiac event (MACE). However, the association between pericarotid artery fat and prognosis remains underexplored. This study aimed to investigate the association between preoperative pericarotid fat characteristics and the subsequent prognosis in patients undergoing carotid endarterectomy (CEA).
Methods
This study included patients with preoperative computed tomography angiography (CTA) followed by CEA. Preoperative neck CTA images were obtained and analyzed with novel methods using 3D Slicer software. We segmented the common and internal carotid arteries. The segment was horizontally trimmed, isolating the region around the bifurcation, extending 15 mm above and 10 mm below. Pericarotid fat was defined as adipose tissue within a 5 mm radial distance from the outer vessel wall, with Hounsfield units (HU) between -190 and -30 (Figure 1, carotid segmentation [green] and pericarotid fat [yellow]). For each patient, we calculated the HU average and the volume (mm3) of the pericarotid fat. MACE was defined as a composite of all-cause mortality, myocardial infarction, and cerebrovascular events. The relationship between both pericarotid fat characteristics and MACE was investigated.
Results
Of the 43 patients initially included, one was excluded due to an inability to perform segmentation caused by chronic total occlusion, leaving 42 patients (age 73 [67-78] years, 33 [76.7%] male). The comparison of mean pericarotid fat HU between the ipsilateral and contralateral sides showed no significant difference (-60.3±11.0 HU vs. -60.9 ±11.3 HU, p=0.437). However, the median ipsilateral fat volume was significantly higher than the contralateral volume (528 [248, 1100] mm3 vs. 328 [184, 697] mm3, p=0.020). When comparing patients with and without MACE, those with MACE had a significantly lower ipsilateral fat density (-59.4±10.2 HU vs. -66.8 ±11.1 HU, p=0.022) and a higher fat volume (468 [233, 746] mm3 vs. 845 [458, 1451] mm3, p=0.044). Kaplan-Meier analysis revealed that higher volume and lower fat density than the median were significant predictors of MACE (log-rank p=0.015 and p=0.042, respectively) (Figure 2).
Conclusions
Assessment of pericarotid fat using a novel CTA analytic method in patients undergoing CEA identified ipsilateral lower fat density and higher fat volume as predictors of adverse outcomes.
  • Kalina, Samuel  ( Mayo Clinic , Rochester , Minnesota , United States )
  • Nogami, Kai  ( Mayo Clinic , Rochester , Minnesota , United States )
  • Mahmoudi, Elham  ( Mayo Clinic , Rochester , Minnesota , United States )
  • Mahmoudi Hamidabad, Negin  ( Mayo Clinic , Rochester , Minnesota , United States )
  • Benson, John  ( Mayo Clinic , Rochester , Minnesota , United States )
  • Saba, Luca  ( University of Cagliari , Cagliari , Italy )
  • Lanzino, Giuseppe  ( Mayo Clinic , Rochester , Minnesota , United States )
  • Nardi, Valentina  ( Mayo Clinic , Rochester , Minnesota , United States )
  • Lerman, Amir  ( Mayo Clinic , Rochester , Minnesota , United States )
  • Author Disclosures:
    Samuel Kalina: DO NOT have relevant financial relationships | Kai Nogami: DO NOT have relevant financial relationships | Elham Mahmoudi: DO NOT have relevant financial relationships | Negin Mahmoudi Hamidabad: DO NOT have relevant financial relationships | John Benson: DO NOT have relevant financial relationships | Luca Saba: DO NOT have relevant financial relationships | Giuseppe Lanzino: DO have relevant financial relationships ; Individual Stocks/Stock Options:Pireus Medical:Active (exists now) | Valentina Nardi: DO NOT have relevant financial relationships | Amir Lerman: DO NOT have relevant financial relationships
Meeting Info:
Session Info:

Risk Factors and Prevention Moderated Poster Tour I

Wednesday, 02/05/2025 , 06:00PM - 07:00PM

Moderated Poster Abstract Session

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