Abstract Body: Background and Objectives: The choice between inhalational and total intravenous anesthesia in revascularization surgery for Moyamoya disease (MMD) remains a topic of debate. Anesthesia methods have changed with the advent of new anesthetics. This study investigated whether modern anesthesia methods affected the development of neurological symptoms following revascularization surgery for MMD.
Methods: This single-center retrospective study included 63 adult patients (82 hemispheres) with MMD treated with direct and indirect bypass surgeries at our hospital between 2013 and 2022. Patients were divided into inhalational anesthesia (IA) and total intravenous anesthesia (TIVA) groups based on the anesthesia maintenance method. Baseline patient characteristics, postoperative neurological symptoms, including hyperperfusion syndrome (HPS), cerebral infarction, and transient neurological events (TNEs), and cortical hyperintensity belt (CHB) sign scores (5-point scale from 0 to 4) on postoperative magnetic resonance imaging were compared between the two groups. The operation methods, anesthetics, and intraoperative hemodynamic and ventilatory parameters were compared between patients with and without TNEs.
Results: The IA and TIVA groups comprised 39 and 43 hemispheres, respectively. The frequency of postoperative HPS and cerebral infarction did not differ between the groups, but the number of TNEs in the IA group (5/39; 13%) was significantly lower than that in the TIVA group (16/43; 37%). Multivariate logistic regression analysis revealed that TNEs were associated with TIVA (odds ratio, 3.91; 95% confidence interval, 1.24–12.35; P = 0.02). The median [interquartile range] postoperative CHB sign score in the IA group (2 [1–3]) was significantly lower than that in the TIVA group (4 [3–4]).
Conclusions: The IA group had fewer postoperative TNEs and lower CHB sign scores than the TIVA group. Although further studies are needed, this study provides insights into the prevention of TNEs with IA and reconsideration of the optimal anesthesia for MMD.