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American Heart Association

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Final ID: TP320

The Kynurenine pathway and its metabolites in stroke: A systematic review and meta-analysis of clinical studies

Abstract Body: Abstract
Background: The kynurenine (KYN) pathway serves as the primary route for tryptophan (TRP) metabolism and plays a crucial role in the occurrence and development of several nervous diseases. The alterations in this pathway have been confirmed in psychiatric disorders, but their role in stroke remains unclear. This review aims to investigate whether metabolites in the TRP-KYN pathway change in patients with stroke.

Methods: We searched PubMed, MEDLINE, Web of Science, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang databases for studies that compare the levels of KYN pathway metabolites between stroke and healthy volunteers. The primary outcome of this study was KYN, and the secondary outcome were TRP, kynurenine/tryptophan ratio (KYN/TRP), and kynurenic acid (KYNA). The Stata software was utilized for data synthesis.

Results: Seven full-length articles with a total of 1080 participants (767 with stroke and 313 healthy volunteers) were included. The results indicated that compared to the control group, stroke patients had significantly lower levels of TRP (standardized mean difference (SMD)=-1.64; 95% CI [-2.36, -0.93]; P<0.0001) and significantly higher levels of the KYN/TRP (SMD=0.69; 95% CI [0.32, 1.07]; P<0.0001). There was also a marginal significance in the levels of KYNA, with the stroke group showing slightly lower levels (SMD=-0.46; 95% CI [-0.99, 0.07]; P=0.09<0.1). In contrast, there was no significant difference in KYN levels between the two groups (SMD=-0.07; 95% CI [-0.32, 0.28]; P=0.59), but the studies inherently exhibited high heterogeneity (I2=63.97%, P=0.01). Further subgroup analysis revealed significant differences between ischemic stroke and hemorrhagic stroke subgroups (P=0.03).

Conclusions: These findings indicate that significant alterations in metabolites of the TRP-KYN pathway of patients with stroke, particularly TRP, KYN/TRP, and KA. Moreover, variations in KYN exhibit significant differences among different stroke types, with more pronounced changes observed in hemorrhagic stroke. Future studies with larger sample sizes are needed to determine whether these biomarkers can be utilized for the identification, diagnosis, and management of stroke.

Keywords: Kynurenine; stroke; tryptophan; kynurenic acid; biomarkers.
  • Liu, Mi  ( Hunan University of Chinese Medicine , Changsha , China )
  • Xie, Haihua  ( Hunan University of Chinese Medicine , Changsha , China )
  • Jiang, Jia  ( Hunan University of Chinese Medicine , Changsha , China )
  • Cao, Sihui  ( Hunan University of Chinese Medicine , Changsha , China )
  • Ding, Changsong  ( Hunan University of Chinese Medicine , Changsha , China )
  • Author Disclosures:
    Mi Liu: DO NOT have relevant financial relationships | Haihua Xie: DO NOT have relevant financial relationships | Jia Jiang: DO NOT have relevant financial relationships | Sihui Cao: DO NOT have relevant financial relationships | Changsong Ding: No Answer
Meeting Info:
Session Info:

Risk Factors and Prevention Posters II

Thursday, 02/06/2025 , 07:00PM - 07:30PM

Poster Abstract Session

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