International Stroke Conference 2025  /  Risk Factors and Prevention Posters I  /  Low-Density Lipoprotein Cholesterol Levels are associated with Vascular Dementia Using Common Data Models
Logo

American Heart Association

  9
  0

Final ID: WP325

Low-Density Lipoprotein Cholesterol Levels are associated with Vascular Dementia Using Common Data Models

Abstract Body: Background
We examined the association between low-density lipoprotein cholesterol (LDL-C) levels and the risk of all-cause dementia including vascular dementia and assessed the impact of statin therapy.
Methods
We used retrospective data from individuals of 10 university hospitals participating in the Observational Medical Outcomes Partnership Common Data Model. The study analyzed 1:1 propensity score matching to compare individuals with LDL-C levels below 70mg/dL against those with levels above 130mg/dL, resulting in a primary analysis cohort of 108,980 matched patients.
Results: The LDL-C levels below 70mg/dL were associated with a 25% reduction in the risk of all-cause dementia, compared to levels above 130mg/dL. For LDL-C levels below 55mg/dL, there was an 19% risk reduction for the outcomes. Among statin users, LDL-C below 70mg/dL also correlated with a reduced risk of all-cause dementia.
Discussion: Lower baseline LDL-C levels were significantly associated with a decreased risk of all-cause dementia including vascular dementia compared to higher LDL-C levels.
  • Kim, Yerim  ( Hallym University College of Med. , Seoul , Korea (the Republic of) )
  • Lee, Minwoo  ( Hallym University College of Med. , Seoul , Korea (the Republic of) )
    • Author Disclosures:
    Yerim Kim: DO NOT have relevant financial relationships | Minwoo Lee: DO NOT have relevant financial relationships
Meeting Info:

International Stroke Conference 2025

2025

Los Angeles, CA

Session Info:

Risk Factors and Prevention Posters I

Wednesday, 02/05/2025 , 07:00PM - 07:30PM

Poster Abstract Session

More abstracts on this topic:
A First-in-Class Humanized Antibody Fragment Targeting Platelet Glycoprotein Ibα: A Comprehensive Preclinical Study of CA1001 for the Treatment of Acute Ischemic Stroke

Xu Xiaohong, Preeti Preeti, Yu Ruoying, Shaykhalishahi Hamed, Zhang Cheng, Shen Chuanbin, Li Bei, Tang Naping, Chang Yan, Xiang Qian, Cui Yimin, Lei Xi, Ni Heyu, Zhu Guangheng, Liu Zhenze, Hu Xudong, Slavkovic Sladjana, Neves Miguel, Ma Wenjing, Xie Huifang

Association Between Circadian Rest/Activity Rhythms and Incident Dementia in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

Wang Wendy, Crainiceanu Ciprian, Spira Adam, Schrack Jennifer, Chen Lin, Wanigatunga Amal, Etzkorn Lacey, Rabinowitz Jill, Palta Priya, Pike James, Dougherty Ryan, Zipunnikov Vadim, Marino Francesca

More abstracts from these authors:
Association between Acute Stage Blood Pressure Variability and Post-Stroke Cognitive Impairment in Atrial Fibrillation-Related Acute Ischemic Stroke

Lee Minwoo, Cheon Dae Young, Choi Sang Won, Kim Yerim

Pre-Existing Depression and Increased Risk of Stroke and Mortality Following Percutaneous Coronary Intervention: A Nationwide Cohort Study

Cheon Dae Young, Lee Minwoo

4168661_File000000.jpg
4168661_File000000.jpg
You have to be authorized to contact abstract author. Please, Login
Not Available

Readers' Comments

We encourage you to enter the discussion by posting your comments and questions below.

Presenters will be notified of your post so that they can respond as appropriate.

This discussion platform is provided to foster engagement, and simulate conversation and knowledge sharing.

 

You have to be authorized to post a comment. Please, Login or Signup.

   Rate this abstract  (Maximum characters: 500)