Abstract Body: Background
We examined the association between low-density lipoprotein cholesterol (LDL-C) levels and the risk of all-cause dementia including vascular dementia and assessed the impact of statin therapy.
Methods
We used retrospective data from individuals of 10 university hospitals participating in the Observational Medical Outcomes Partnership Common Data Model. The study analyzed 1:1 propensity score matching to compare individuals with LDL-C levels below 70mg/dL against those with levels above 130mg/dL, resulting in a primary analysis cohort of 108,980 matched patients.
Results: The LDL-C levels below 70mg/dL were associated with a 25% reduction in the risk of all-cause dementia, compared to levels above 130mg/dL. For LDL-C levels below 55mg/dL, there was an 19% risk reduction for the outcomes. Among statin users, LDL-C below 70mg/dL also correlated with a reduced risk of all-cause dementia.
Discussion: Lower baseline LDL-C levels were significantly associated with a decreased risk of all-cause dementia including vascular dementia compared to higher LDL-C levels.