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American Heart Association

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Final ID: WP271

Low Endothelial Shear Stress is Associated with Early Neurological Deterioration in Patients with Single Subcortical Infarction

Abstract Body: Introduction: Patients with single subcortical infarction (SSI) have relatively favorable prognosis, but they often experience early neurological deterioration (END) in a clinical course. Endothelial shear stress (ESS) applied to the vascular wall may also be one of the causes.
Hypothesis: We would like to analyze the association between ESS and occurrence of END in SSI patients.
Methods: We included consecutive patients with SSI within 72 hours of symptom onset between 2010 and 2020. END was defined as an increase of ≥ 2 in the total NIHSS score or ≥ 1 in the motor NIHSS score within the first 72 hours of admission. As a parameter for ESS, the signal intensity gradient (SIG) value was obtained at the vessel boundary in time-of-flight image in initial brain magnetic resonance angiography. The maximum, minimum, mean, and standard deviation of SIG were obtained from all intracranial vessels. Among them, the SIG value of the relevant vessel that caused SSI was taken as the main independent variable.
Results: A total of 495 patients with SSI were evaluated (median age: 67 years, END prevalence: 17.2%). In multivariable analysis, the mean SIG value of relevant vessels was significantly associated with END (adjusted odds ratio = 0.81, 95% confidence interval: 0.68-0.97). However, maximum, minimum, or standard deviation SIG value of relevant vessel was not associated with END. Additionally, the mean SIG value of the whole intracranial vessel also showed no correlation with the occurrence of END. The statistical correlation between the average SIG value of relative vessels and END was clearly evident in distal SSI, but the correlation was lost in proximal SSI. Age or proximal type SSI also showed an association with END regardless of SIG value.
Conclusions: In patients with acute SSI, the mean SIG value of relevant vessels showed a negative association with the occurrence of END. In other words, if the ESS applied to the relevant vessel where the index stroke occurred is weak, END may occur relatively easily. This tendency was more evident in patients with distal SSI lesions.
  • Nam, Ki-woong  ( SMG-SNUBMC , Seoul , Korea (the Republic of) )
  • Kwon, Hyung-min  ( SMG-SNUBMC , Seoul , Korea (the Republic of) )
  • Lee, Yongseok  ( SMG-SNUBMC , Seoul , Korea (the Republic of) )
  • Author Disclosures:
    Ki-Woong Nam: DO NOT have relevant financial relationships | Hyung-Min Kwon: DO NOT have relevant financial relationships | Yongseok Lee: No Answer
Meeting Info:
Session Info:

Risk Factors and Prevention Posters I

Wednesday, 02/05/2025 , 07:00PM - 07:30PM

Poster Abstract Session

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