Abstract Body: Introduction: Hypertension remains the leading cause of death worldwide despite readily available medication options. Renal denervation (RDN) has emerged as a promising non-pharmacologic therapeutic option for uncontrolled hypertensive patients. Currently two RDN systems are approved by the Food and Drug Administration. The Paradise® ultrasound RDN system has been shown to be safe and effective in multiple randomized clinical trials. We evaluated the therapy at a single center under real world clinical practice conditions.

Hypothesis: We assessed the hypothesis that the Paradise® ultrasound RDN system would lower office blood pressure safely and effectively in hypertensive patients under real world clinical practice conditions.

Methods: Twenty consecutive patients were treated with the Paradise System at the Mon Health Medical Center in Morgantown, West Virgina. Data collected included baseline clinical characteristics, office blood pressure (OBP), prescribed antihypertensive medications and procedural characteristics. Follow-up BP was obtained at 1, 3, 6, and 12-months post procedure.

Results: Thirty percent of patients were female, and average age was 69.1± 9.9 yrs. Baseline OBP was 167/85 mmHg, and patients were prescribed an average of 4.4 antihypertensive medications. Total procedure times were short (37 ± 21min) with an average of 6.3 ablations and an ablation time of 44 secs. At the 1-month follow-up, the average reduction in OBP was -13/-8 mmHg (n=19) with no change in average number of antihypertensive medications. 13/19 patients (68%) experienced a reduction in systolic BP of ≥ 5 mmHg with an average change in systolic BP for these patients of -26.5 mmHg. At 6- months of follow up the average OBP was 154/82 mmHg (n=11).

Conclusions: In conclusion, RDN with the Paradise ultrasound System appears to be safe and effective in real world clinical practice. Patients were typically older than in previous randomized, controlled trials, on multiple medications and with BP reductions as early as 1 month post procedure that were maintained for at least 6 months.