Abstract Body: Study rationale: Nocturia, defined as waking to void during sleep hours, is common in adults, and is associated with hypertension and higher cardiovascular (CV) risk. Our group also found that nocturia is strongly associated with hypertension in adolescents. While previous studies have found nocturia more specifically related to SBP elevation in adults, younger individuals with hypertension are more likely to exhibit elevated diastolic (D) BP and DBP carries greater prognostic significance. Also, younger individuals exhibit higher pulse pressure amplification than older ones. Data on relations between nocturia and specific BP indices are sparse. Accordingly, this study sought to determine which specific BP indices are more strongly correlated with nocturia severity in adolescents.

Methods: We recruited 100 adolescents, ages 10–18 years, from pediatric clinics at an inner-city Brooklyn hospital. Peripheral and central BP measurements, using non-invasive applanation tonometry, were obtained. Participants completed nocturnal-only voiding diaries. Spearman’s rank correlation coefficient and Poisson regression was used to assess the relationship between BP and nocturia indices.

Results: Amongst all subjects, 45 reported nocturia. Peripheral SBP and central BP showed moderate positive correlations with nocturia frequency (highest SBP of both arms r = 0.33, p=0.001; central SBP r =0.27, p=0.007). The highest SBP was significantly correlated with nocturnal urine volume (NUV) (r = 0.31, p = 0.001) and nocturnal urine production (NUP) (r = 0.32, p = 0.001), but not with maximum voided volume (MVV) (r = 0.11, p=0.25). DBP showed no significant correlations. After adjusting for BMI and sex, SBP remained a significant predictor of nocturia frequency.

Conclusions: In adolescents SBP is strongly associated with nocturia frequency, NUV, NUP, but not MVV. Therefore, higher SBP is associated with nocturia frequency and increased nocturnal urine production, but not to lower bladder capacity. These findings suggest that nocturia may reflect early alterations in BP regulation.