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American Heart Association

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Final ID: P-386

Predictors of Home Blood Pressure Response to Ultrasound Renal Denervation

Abstract Body: BACKGROUND: Out-of-office blood pressure measurements are recommended for hypertension (HTN) management. The RADIANCE clinical trial program showed that ultrasound renal denervation (uRDN) significantly reduces daytime ambulatory systolic blood pressure (SBP) in patients with mild-to-moderate HTN (RADIANCE-HTN SOLO, RADIANCE II) and resistant HTN (RADIANCE-HTN TRIO). Previous analyses have assessed predictors of daytime ambulatory SBP response at 2-months. This analysis assessed predictors of home SBP (HSBP) at 2-months.
METHOD: This analysis included 250 patients who were randomized to and received uRDN and were treated per-protocol. Separate linear regression models were used to assess predictors of the change in HSBP at 2-months. Multivariable regression analysis was conducted including variables with p-value<0.20. Backward selection with a stay criterion of 0.20 was used to select the predictors for the final multivariable analysis. Study was pre-defined as a covariate in the final model.
RESULTS: Patients were 69% male and 76% white; average age was 53.9 years and baseline office BP 155.5/101.5 mmHg. The only significant predictor (p< 0.05) resulting from the separate linear regression models adjusting for cohort was baseline HSBP. Other predictors included in the multivariable analyses (p<0.20) were sex, black race, screening medications(Y/N), orthostatic HTN, and right renal artery diameter. In the multivariable analyses, baseline HSBP was the only significant predictor of change in HSBP at 2-months (p=0.009, See Table).
CONCLUSIONS: In this analysis of response to treatment with uRDN using home BPs, baseline HSBP was the only consistent significant predictor of response. Baseline BP value as a predictor of RDN response is consistent with prior analyses.
  • Sharp, Andrew  ( University Hospital of Wales , Cardiff , United Kingdom )
  • Azizi, Michel  ( Universite Paris Descartes , Paris , France )
  • Kirtane, Ajay  ( Columbia University Medical Center , New York , New York , United States )
  • Bloch, Michael  ( Blue Spruce Medicine Concultants , Reno , Nevada , United States )
  • Baker, Lemont  ( Recor Medical , Palo Alto , California , United States )
  • Mcclure, Candace K  ( NAMSA , Minneapolis , Minnesota , United States )
  • Fisher, Naomi  ( BRIGHAM WOMENS HOSPITAL , Boston , Massachusetts , United States )
  • Author Disclosures:
    Andrew Sharp: No Answer | Michel Azizi: No Answer | Ajay Kirtane: No Answer | Michael Bloch: No Answer | Lemont Baker: DO NOT have relevant financial relationships | Candace K McClure: No Answer | Naomi Fisher: DO have relevant financial relationships ; Consultant:Recor Medical:Active (exists now) ; Consultant:Medtronic:Past (completed) ; Consultant:Aktiia:Active (exists now) ; Consultant:Astra Zeneca:Active (exists now) ; Research Funding (PI or named investigator):Recor Medical:Active (exists now)
Meeting Info:
Session Info:

Poster Session 2

Friday, 09/06/2024 , 09:00AM - 10:30AM

Poster Session

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