The DASH Dietary Pattern and Risk of Cardiovascular Disease Mortality During 1988-2019 in US Adults: A Population-Based Cohort Study
Abstract Body: Introduction: The Dietary Approaches to Stop Hypertension (DASH) diet reduces cardiovascular disease (CVD) risk factors in clinical trials and has been associated with reduced CVD risk. However, evidence on reduced CVD mortality outcomes has yet to be observed in the National Health and Nutrition Examination Survey (NHANES), a representative sample of the US population, possibly due to an insufficient follow-up in early analyses and a limited dietary exposure assessment.
Objective: To examine the association between the DASH dietary pattern and CVD mortality with a longer follow-up using a food-based score and a more robust dietary exposure assessment.
Methods: A total of 13,586 nonpregnant adults without a history of CVD were included from NHANES (1988-1994). Diet was assessed by a 24-hour dietary recall supplemented with a food frequency questionnaire at baseline using the DASH-style diet adherence score (DASH score) with positive points for servings of fruits, vegetables, nuts and legumes, whole grains, and low-fat dairy products, and negative points for total dietary sodium, servings of red and processed meats, and sweetened beverages (range, 8-40 points). Mortality data were obtained from National Death Index records until 31 December 2019. Weighted Cox proportional hazards regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). The primary outcome was CVD-mortality. Other mortality outcomes included coronary heart disease (CHD), stroke, and all-cause mortality.
Results: During a mean follow-up of 23-years, 1,751 CVD deaths, including 1,416 CHD, 335 stroke deaths and 5,202 all-cause deaths were documented over 311,826 person-years. After multivariable adjustments comparing the highest to lowest tertiles of the DASH score, participants with higher DASH scores were associated with 24% (HR: 0.76 [95% CI: 0.61, 0.94]), 25% (0.75 [0.60, 0.95]) and 19% (0.82 [0.71, 0.94]) lower risk of CVD, CHD, and all-cause mortality, respectively. There was no association with stroke mortality (0.80 [0.48, 1.38]). An increase in DASH score by 10-points was associated with a 20% (0.80 [0.70, 0.93]), 23% (0.77 [0.65, 0.90]), and 18% (0.82 [0.75, 0.90]) lower risk of CVD, CHD, and all-cause mortality, respectively.
Conclusion: Among US adults, greater adherence to a food-based DASH score was inversely associated with CVD, CHD, and all-cause mortality.
Kavanagh, Meaghan
( University of Toronto
, Toronto
, Ontario
, Canada
)
Zurbau, Andreea
( University of Toronto
, North York
, Ontario
, Canada
)
Glenn, Andrea
( New York University
, New York
, New York
, United States
)
Chiavaroli, Laura
( University of Toronto
, Toronto
, Ontario
, Canada
)
Kendall, Cyril
( University of Toronto
, Toronto On
, Ontario
, Canada
)
Jenkins, David
( University of Toronto
, North York
, Ontario
, Canada
)
Sievenpiper, John
( University of Toronto
, Toronto On
, Ontario
, Canada
)
Author Disclosures:
Meaghan Kavanagh:DO have relevant financial relationships
;
Research Funding (PI or named investigator):Canadian Institutes of Health Research :Active (exists now)
| Andreea Zurbau:No Answer
| Andrea Glenn:DO NOT have relevant financial relationships
| Laura Chiavaroli:No Answer
| Cyril Kendall:DO NOT have relevant financial relationships
| David Jenkins:No Answer
| John Sievenpiper:No Answer
Mei Zhendong, Liang Liming, Hu Frank, Li Jun, Wang Xingyan, Yun Huan, Sevilla-gonzalez Magdalena, Hu Jie, Bhupathiraju Shilpa, Sun Qi, Stampfer Meir, Willett Walter
