Abstract Body: Introduction: Increased left ventricular mass (LVM) is a risk factor for adult CV disease and is associated with hyperlipidemia. The effects of the burden of different lipids during adolescence on increased LVM in young adulthood are not well described.

Hypothesis: We hypothesized that the burden of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) across adolescence would be associated with increased LVM in women during young adulthood.

Methods: We analyzed data from the National Growth and Health Study, a longitudinal study of racial differences in CV risk factors in young women. Serum lipids (collected at ages 14-20) and left ventricular mass (LVM) by echocardiography (assessed at ages 24-27) were the primary variables of interest. Adolescent measures of lipids, BMI and systolic blood pressure (SBP) were summarized as the area under the curve (AUC), and LVM was indexed by dividing by height^2.7. Adjusted linear regression analysis was used to assess the associations of HDL-C, LDL-C, and TG AUCs with LVM Index (LVMI). in a combined model to assess for contributions to LVMI. Models were adjusted for BMI AUC, race, and systolic blood pressure AUC amongst all participants and then models were repeated after stratifying by race.

Results: The analysis included 517 women (52.6% Black, mean age 24.9 ± 0.7 yrs at time of echocardiography). In analyses including all lipids (Table), TG was significantly associated with increased LVMI (0.06±0.03, p=0.02, R²=0.40), along with BMI (0.65±0.05, p<0.01) and Black race (0.06±0.02, p<0.01), while HDL, LDL, and SBP were not. These findings were similar to models of each lipid analyzed individually. Stratifying by race (Table), TG remained the only lipid significantly associated with increased LVMI in Black participants (0.08±0.04, p=0.04, R²=0.39), along with BMI (0.64±0.06, p<0.01). In White participants, BMI was the only covariate that was significantly associated with increased LVMI (0.66±0.09, p<0.01, R²=0.33).

Conclusions: In conclusion, the burden of TG over adolescence is associated with increased LVMI in early adulthood, particularly in Black women. Interventions should be targeted toward reducing TG to prevent early cardiac disease.