Basic Cardiovascular Sciences 2025  /  Poster Session and Reception 2  /  Tunneling Nanotube-Like structures regulate distant cellular interactions during heart formation
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American Heart Association

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Final ID: Thu059

Tunneling Nanotube-Like structures regulate distant cellular interactions during heart formation

Abstract Body: In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood. Working in developing mouse cardiac morphogenesis models, we used a variety of cellular, imaging, and genetic approaches to elucidate this question. We found that myocardium and endocardium interacted directly via microstructures termed Tunneling Nanotube-Like structures (TNTLs). TNTLs extended from cardiomyocytes (CMs) to contact endocardial cells (ECs) directly. TNTLs transported cytoplasmic proteins, transduced signals between CMs and ECs, and initiated myocardial growth toward the heart lumen to form ventricular trabeculae-like structures. Loss of TNTLs disturbed signaling interactions and, subsequently, ventricular patterning.
  • Wu, Mingfu  ( University of Houston , Houston , Texas , United States )
  • Miao, Lianjie  ( University of Houston , Sugar Land , Texas , United States )
    • Author Disclosures:
    Mingfu Wu: DO NOT have relevant financial relationships | Lianjie Miao: DO NOT have relevant financial relationships
Meeting Info:

Basic Cardiovascular Sciences 2025

2025

Baltimore, Maryland

Session Info:

Poster Session and Reception 2

Thursday, 07/24/2025 , 04:30PM - 07:00PM

Poster Session and Reception

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