Abstract Body: Background:
Follicular lymphoma (FL) is typically a slow-growing form of non-Hodgkin lymphoma (NHL) that arises from B-lymphocytes. Large-scale studies are lacking for the outcomes of patients with ventricular arrhythmias and FL. We retrospectively reviewed FL patients with ventricular tachycardia utilizing the National Inpatient Sample (NIS) database. Our analysis aimed to identify risk factors that worsen outcomes in patients with FL and ventricular arrhythmias and evaluate the impact of ventricular arrhythmias on in-hospital outcomes of patients with FL.
Methods:
Data were extracted from the National Inpatient Sample (NIS) 2016-2019 Database. The NIS was searched for hospitalizations for adult patients with FL as the principal discharge diagnosis with and without ventricular arrhythmias as a secondary diagnosis using ICD-10 codes. The primary outcome was inpatient mortality. Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders. STATA software was used for analysis.
Results:
This study included 15,795 patients with FL of which 225 had ventricular arrhythmias. Patients with both FL and an associated ventricular arrhythmia had higher inpatient mortality (OR 5.44, CI 2.48-11.93, p<0.0001), hospital length of stay (LOS) (+5.48 days, CI 3.27-7.68, p<0.0001) and total hospital charges (TOTHCG) (+$109,117.3, CI $65,702.9- $152,531.7, p<0.0001). In this patient population, the secondary analysis revealed that mortality was increased if patients had a cardiac arrest (OR 25.62, CI 1.36-484.48, p<0.031). LOS was increased in the presence of an acute kidney injury (+0.34 days, 0.04-0.64, p<0.026).
Conclusions:
Our study revealed that patients with FL and ventricular arrhythmias had increased mortality, hospital LOS, and TOTHCG, as well as much higher rates of complications, including cardiac arrest and acute kidney injury, compared to those without ventricular arrhythmias. Efforts to prevent, monitor, and aggressively manage ventricular arrhythmias in patients with FL will improve overall outcomes.